- Rough eye is a gain-of-function allele of amos that disrupts regulation of the proneural gene atonal during Drosophila retinal differentiation. Chanut, F., Woo, K., Pereira, S., Donohoe, T.J., Chang, S.Y., Laverty, T.R., Jarman, A.P., Heberlein, U. Genetics (2002)