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Gene Review

amos  -  absent MD neurons and olfactory sensilla

Drosophila melanogaster

Synonyms: Absent MD neurons and olfactory sensilla protein, Amos, Amos protein, Basic helix-loop-helix transcription factor amos, CG10393, ...
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Disease relevance of amos


High impact information on amos


Biological context of amos

  • One revertant is a loss-of-function allele of amos and has a recessive phenotype in the embryonic PNS [1].
  • Our molecular characterization of the Roi locus demonstrates that it is a gain-of-function mutation of the bHLH gene amos that results from a chromosomal inversion [6].
  • However, unlike other proneural genes, there is no evidence for separable enhancers for the different temporal phases of amos expression [7].
  • GFP reporter gene constructs were used to demonstrate that amos has an array of enhancer elements up- and downstream of the gene, which are required for different locations of amos expression [7].
  • Using mutant analysis and site-directed mutagenesis of potential Amos binding sites, we find no evidence for positive autoregulation as an important part of amos control during neurogenesis [7].

Anatomical context of amos

  • This causes ectopic expression of amos in large domains of the lateral-dorsal embryonic ectoderm, which results in supernumerary neurons of the PNS, and in the notum region of the third instar imaginal wing, which gives rise to the mesothoracic extra bristles [1].

Other interactions of amos

  • Unlike other ectopic bristle mutants, Tufted is epistatic to achaete and scute, the proneural genes that normally control the development of these sensory organs [8].
  • The ability of Tft(1) bristles to appear close together may be due to amos having a stronger proneural capacity than that of other proneural genes like asense and scute [1].
  • amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge [3].
  • This supports a model of inhibitory interactions between proneural genes, whereby ato-like genes (amos and ato) must suppress sensory bristle fate as well as promote alternative sense organ subtypes [9].


  1. Tufted is a gain-of-function allele that promotes ectopic expression of the proneural gene amos in Drosophila. Villa-Cuesta, E., de Navascués, J., Ruiz-Gómez, M., Diez del Corral, R., Domínguez, M., de Celis, J.F., Modolell, J. Genetics (2003) [Pubmed]
  2. Programmed cell death and context dependent activation of the EGF pathway regulate gliogenesis in the Drosophila olfactory system. Sen, A., Kuruvilla, D., Pinto, L., Sarin, A., Rodrigues, V. Mech. Dev. (2004) [Pubmed]
  3. amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge. Goulding, S.E., zur Lage, P., Jarman, A.P. Neuron (2000) [Pubmed]
  4. The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system. Huang, M.L., Hsu, C.H., Chien, C.T. Neuron (2000) [Pubmed]
  5. Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila. Blard, O., Feuillette, S., Bou, J., Chaumette, B., Frébourg, T., Campion, D., Lecourtois, M. Hum. Mol. Genet. (2007) [Pubmed]
  6. Rough eye is a gain-of-function allele of amos that disrupts regulation of the proneural gene atonal during Drosophila retinal differentiation. Chanut, F., Woo, K., Pereira, S., Donohoe, T.J., Chang, S.Y., Laverty, T.R., Jarman, A.P., Heberlein, U. Genetics (2002) [Pubmed]
  7. Multiple enhancers contribute to spatial but not temporal complexity in the expression of the proneural gene, amos. Holohan, E.E., Zur Lage, P.I., Jarman, A.P. BMC Dev. Biol. (2006) [Pubmed]
  8. Drosophila tufted is a gain-of-function allele of the proneural gene amos. Lai, E.C. Genetics (2003) [Pubmed]
  9. The Drosophila proneural gene amos promotes olfactory sensillum formation and suppresses bristle formation. zur Lage, P.I., Prentice, D.R., Holohan, E.E., Jarman, A.P. Development (2003) [Pubmed]
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