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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Pulmonary miliary tuberculosis in a patient with anti-TNF-alpha treatment.

No difference in the number of serious adverse events was reported in previous clinical trials in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) patients treated with TNF-alpha blockade, but a patient died because of disseminated tuberculosis. A tuberculosis reactivation in a patient with IBD and anti-TNF-alpha treatment has been recently reported. Very recently 70 cases of tuberculosis were reported from the FDA Adverse Event Reporting System. We report a case of pulmonary miliary tuberculosis in a RA patient treated with TNF-alpha blockade. The important role of TNF-alpha in defence against tuberculosis and possible mechanisms of anti-TNF-alpha agents impairing tuberculosis immune response are discussed.[1]


  1. Pulmonary miliary tuberculosis in a patient with anti-TNF-alpha treatment. Mayordomo, L., Marenco, J.L., Gomez-Mateos, J., Rejon, E. Scand. J. Rheumatol. (2002) [Pubmed]
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