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Cronan, J.E.

Cronan,

Phospholipid modifications in bacteria.

Many bacteria alter the acyl chains of their membrane phospholipids in response to changing environmental conditions. Two of these modifications are reviewed: cis-->trans isomerization and cyclopropanation of double bonds. The isomerization reaction is now known to be catalyzed by a periplasmic protein that contains a covalently bound heme. Cyclopropanation has been shown to play a role in Mycobacterium tuberculosis pathogenesis and, in Escherichia coli, plays an important role in resistance to acidic conditions.[1]

References

Phospholipid modifications in bacteria. Cronan, J.E. Curr. Opin. Microbiol. (2002) [Pubmed]

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