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Darvesh, S. et al.

Darvesh, MacKnight, Rockwood,

Butyrylcholinesterase and cognitive function.

Butyrylcholinesterase (BuChE) is expressed in brain structures involved in cognition, but the effect of selective BuChE inhibitors on human cognitive function is unknown. We report a patient whose cognitive function deteriorated following a reduction and improved following reinstitution of ethopropazine, a selective BuChE inhibitor. We suggest that, because neurons expressing BuChE may be involved in cognition, there is merit to further evaluation of selective BuChE inhibitors in treating cognitive dysfunction.[1]

References

Butyrylcholinesterase and cognitive function. Darvesh, S., MacKnight, C., Rockwood, K. International psychogeriatrics / IPA. (2001) [Pubmed]

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