Gene Review:
BCHE - butyrylcholinesterase
Homo sapiens
Synonyms:
Acylcholine acylhydrolase, Butyrylcholine esterase, CHE1, CHE2, Choline esterase II, ...
Kuhl,
Nassar,
O'Neill,
Andersen,
Glümer,
Rafael Blesa,
Bevin,
Darvesh,
Giuseppe Gambina,
Howard Bergman,
Rockwood,
Jørgensen,
Johansen,
Frey,
Snyder,
Bata,
Hansen,
Kirkland,
Hamid,
Title,
Drivsholm,
Koeppe,
Kilbourn,
Günter Rapatz,
Johnstone,
Jensen,
Yunsheng He,
Steven Ferris,
Agneta Nordberg,
Hilkka Soininen,
Taher Darreh-Shori,
Roger Lane,
Borch-Johnsen,
Pedersen,
Joanne Meyer,
Nielsen,
Jennifer Nagel,
Roger Bullock,
Roger Lane,
Minoshima,
- Amplification of the genes BCHE and SLC2A2 in 40% of squamous cell carcinoma of the lung. Brass, N., Rácz, A., Heckel, D., Remberger, K., Sybrecht, G.W., Meese, E.U. Cancer Res. (1997)
- Butyrylcholinesterase (BCHE) genotyping for post-succinylcholine apnea in an Australian population. Yen, T., Nightingale, B.N., Burns, J.C., Sullivan, D.R., Stewart, P.M. Clin. Chem. (2003)
- In vivo gene amplification in non-cancerous cells: cholinesterase genes and oncogenes amplify in thrombocytopenia associated with lupus erythematosus. Zakut, H., Lapidot-Lifson, Y., Beeri, R., Ballin, A., Soreq, H. Mutat. Res. (1992)
- Mutations and impaired expression in the ACHE and BCHE genes: neurological implications. Soreq, H., Ehrlich, G., Schwarz, M., Loewenstein, Y., Glick, D., Zakut, H. Biomed. Pharmacother. (1994)
- Butyrylcholinesterase attenuates amyloid fibril formation in vitro. Diamant, S., Podoly, E., Friedler, A., Ligumsky, H., Livnah, O., Soreq, H. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Increased serum butyrylcholinesterase activity in type IIb hyperlipidaemic patients. Kálmán, J., Juhász, A., Rakonczay, Z., Abrahám, G., Zana, M., Boda, K., Farkas, T., Penke, B., Janka, Z. Life Sci. (2004)
- Cerebrospinal fluid cholinesterases in aging and in dementia of the Alzheimer type. Atack, J.R., May, C., Kaye, J.A., Kay, A.D., Rapoport, S.I. Ann. Neurol. (1988)
- Sustained cholinesterase inhibition in AD patients receiving rivastigmine for 12 months. Darreh-Shori, T., Almkvist, O., Guan, Z.Z., Garlind, A., Strandberg, B., Svensson, A.L., Soreq, H., Hellström-Lindahl, E., Nordberg, A. Neurology (2002)
- Wild-type and A328W mutant human butyrylcholinesterase tetramers expressed in Chinese hamster ovary cells have a 16-hour half-life in the circulation and protect mice from cocaine toxicity. Duysen, E.G., Bartels, C.F., Lockridge, O. J. Pharmacol. Exp. Ther. (2002)
- Adenovirus 2 Ip+ locus codes for a 19 kd tumor antigen that plays an essential role in cell transformation. Chinnadurai, G. Cell (1983)
- Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8. Walden, H., Podgorski, M.S., Schulman, B.A. Nature (2003)
- Interaction of E1 and hSNF5 proteins stimulates replication of human papillomavirus DNA. Lee, D., Sohn, H., Kalpana, G.V., Choe, J. Nature (1999)
- Genetic predisposition to adverse consequences of anti-cholinesterases in 'atypical' BCHE carriers. Loewenstein-Lichtenstein, Y., Schwarz, M., Glick, D., Nørgaard-Pedersen, B., Zakut, H., Soreq, H. Nat. Med. (1995)
- Relation between butyrylcholinesterase K variant, paraoxonase 1 (PON1) Q and R and apolipoprotein E epsilon 4 genes in early-onset coronary artery disease. Nassar, B.A., Darvesh, S., Bevin, L.D., Rockwood, K., Kirkland, S.A., O'Neill, B.J., Bata, I.R., Johnstone, D.E., Title, L.M. Clin. Biochem. (2002)
- Neither the butyrylcholinesterase K variant nor transferrin C2 variant confers a risk for Alzheimer's disease in Koreans. Kim, K.W., Jhoo, J.H., Lee, J.H., Lee, K.U., Lee, D.Y., Youn, J.C., Youn, J.Y., Woo, J.I. Journal of neural transmission (Vienna, Austria : 1996) (2001)
- The cloned butyrylcholinesterase (BCHE) gene maps to a single chromosome site, 3q26. Allderdice, P.W., Gardner, H.A., Galutira, D., Lockridge, O., LaDu, B.N., McAlpine, P.J. Genomics (1991)
- Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5- phenotypes. Alcântara, V.M., Oliveira, L.C., Réa, R.R., Suplicy, H.L., Chautard-Freire-Maia, E.A. Int. J. Obes. Relat. Metab. Disord. (2003)
- Effect of butyrylcholinesterase genotype on the response to rivastigmine or donepezil in younger patients with Alzheimer's disease. Blesa, R., Bullock, R., He, Y., Bergman, H., Gambina, G., Meyer, J., Rapatz, G., Nagel, J., Lane, R. Pharmacogenet. Genomics (2006)
- Promoter and transcription start site of human and rabbit butyrylcholinesterase genes. Jbilo, O., Toutant, J.P., Vatsis, K.P., Chatonnet, A., Lockridge, O. J. Biol. Chem. (1994)
- Butyrylcholinesterase K variant is genetically associated with late onset Alzheimer's disease in Northern Ireland. McIlroy, S.P., Crawford, V.L., Dynan, K.B., McGleenon, B.M., Vahidassr, M.D., Lawson, J.T., Passmore, A.P. J. Med. Genet. (2000)
- Mapping the human acetylcholinesterase gene to chromosome 7q22 by fluorescent in situ hybridization coupled with selective PCR amplification from a somatic hybrid cell panel and chromosome-sorted DNA libraries. Ehrlich, G., Viegas-Pequignot, E., Ginzberg, D., Sindel, L., Soreq, H., Zakut, H. Genomics (1992)
- Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion. Johansen, A., Nielsen, E.M., Andersen, G., Hamid, Y.H., Jensen, D.P., Glümer, C., Drivsholm, T., Borch-Johnsen, K., Jørgensen, T., Hansen, T., Pedersen, O. Diabetologia (2004)
- Butyrylcholinesterase variants (BCHE and CHE2 Loci) associated with erythrocyte acetylcholinesterase inhibition in farmers exposed to pesticides. Fontoura-da-Silva, S.E., Chautard-Freire-Maia, E.A. Hum. Hered. (1996)
- In vivo butyrylcholinesterase activity is not increased in Alzheimer's disease synapses. Kuhl, D.E., Koeppe, R.A., Snyder, S.E., Minoshima, S., Frey, K.A., Kilbourn, M.R. Ann. Neurol. (2006)
- Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE epsilon4 allele, in relation to cognitive function and cerebral glucose metabolism. Darreh-Shori, T., Brimijoin, S., Kadir, A., Almkvist, O., Nordberg, A. Neurobiol. Dis. (2006)
- Overlapping drug interaction sites of human butyrylcholinesterase dissected by site-directed mutagenesis. Loewenstein-Lichtenstein, Y., Glick, D., Gluzman, N., Sternfeld, M., Zakut, H., Soreq, H. Mol. Pharmacol. (1996)
- Progression from mild cognitive impairment to Alzheimer's disease: effects of sex, butyrylcholinesterase genotype, and rivastigmine treatment. Ferris, S., Nordberg, A., Soininen, H., Darreh-Shori, T., Lane, R. Pharmacogenet. Genomics (2009)
- The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action. Harel, M., Hyatt, J.L., Brumshtein, B., Morton, C.L., Yoon, K.J., Wadkins, R.M., Silman, I., Sussman, J.L., Potter, P.M. Mol. Pharmacol. (2005)
- Ultrastructural localization of butyrylcholinesterase in senile plaques in the brains of aged and Alzheimer disease patients. Gómez-Ramos, P., Morán, M.A. Mol. Chem. Neuropathol. (1997)
- Human erythrocyte but not brain acetylcholinesterase hydrolyses heroin to morphine. Salmon, A.Y., Goren, Z., Avissar, Y., Soreq, H. Clin. Exp. Pharmacol. Physiol. (1999)
- Protease inhibitors and indoleamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer disease. Wright, C.I., Guela, C., Mesulam, M.M. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease. Brindle, N., Song, Y., Rogaeva, E., Premkumar, S., Levesque, G., Yu, G., Ikeda, M., Nishimura, M., Paterson, A., Sorbi, S., Duara, R., Farrer, L., St George-Hyslop, P. Hum. Mol. Genet. (1998)
- Evaluation of polymorphisms in the presenilin-1 gene and the butyrylcholinesterase gene as risk factors in sporadic Alzheimer's disease. Tilley, L., Morgan, K., Grainger, J., Marsters, P., Morgan, L., Lowe, J., Xuereb, J., Wischik, C., Harrington, C., Kalsheker, N. Eur. J. Hum. Genet. (1999)
- Analysis of mutations in the plasma cholinesterase gene of patients with a history of prolonged neuromuscular block during anesthesia. Barta, C., Sasvari-Szekely, M., Devai, A., Kovacs, E., Staub, M., Enyedi, P. Mol. Genet. Metab. (2001)
- Acetylcholinesterase and butyrylcholinesterase expression in adult rabbit tissues and during development. Jbilo, O., L'Hermite, Y., Talesa, V., Toutant, J.P., Chatonnet, A. Eur. J. Biochem. (1994)
- Butyrylcholinesterase in human brain and acetylcholinesterase in human plasma: trace enzymes measured by two-site immunoassay. Brimijoin, S., Hammond, P. J. Neurochem. (1988)