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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A method for easily determining coupling constant values: an addendum to "A practical guide to first-order multiplet analysis in 1H NMR spectroscopy".

A systematic procedure to decipher first-order 1H NMR multiplets is described. This method is a very practical tool for extracting coupling constant values. It requires only that one (a) learn to identify each of the 2n (n = number of spin 1/2 nuclei to which the proton is coupled) "units of intensity" of a multiplet and (b) then apply a clearly delineated sequence of iterative steps that allows the J's to be assigned in order (from smallest to largest). The approach is even easier to use than one described previously (J. Org. Chem. 1994, 59, 4096-4103).[1]

References

  1. A method for easily determining coupling constant values: an addendum to "A practical guide to first-order multiplet analysis in 1H NMR spectroscopy". Hoye, T.R., Zhao, H. J. Org. Chem. (2002) [Pubmed]
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