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Gene Review

SPIN1  -  spindlin 1

Homo sapiens

Synonyms: OCR, Ovarian cancer-related protein, SPIN, Spindlin-1, Spindlin1
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Disease relevance of SPIN1

  • RESULTS: OCR data demonstrated that, in some settings, such as colorectal cancer, the proportions of elderly cancer patients who were referred to cancer centers and who received any cancer treatment were lower than their younger counterparts [1].
  • METHODS: The Ontario Cancer Registry (OCR) was used to identify 295,386 cases of invasive cancer, excluding nonmelanoma skin cancer, which were diagnosed in Ontario between 1984 and 1991 [2].
  • OCR was absent in CS and in AN patients with hypercorticism, whereas their circadian cortisol cycle was maintained [3].
  • In AN, weight gain (n = 13) induced a significant decrease in cortisol levels in hypercortisolic AN patients, and restored normal osteocalcin levels and OCR [3].
  • Spectra (Spin Echo sequence, TE 135 ms) were acquired by single voxel, localised on focal lesions in toxoplasmosis, PML, lymphomas, and HIV encephalopathies and on the centrum semiovale of neurological controls [4].

High impact information on SPIN1

  • (Beta)-galactosidase-tagged reporter transcripts containing each of the different Spin 3'UTRs were injected into oocytes and zygotes and (beta)-galactosidase activity was monitored [5].
  • The Spin gene has three transcripts, each with an identical open reading frame and a different 3' untranslated region (UTR) [5].
  • We find that spindlin associates with the meiotic spindle and is modified by phosphorylation in a cell-cycle-dependent fashion [6].
  • Spindlin, a major maternal transcript expressed in the mouse during the transition from oocyte to embryo [6].
  • Our data suggest that spindlin plays a role in cell-cycle regulation during the transition from gamete to embryo [6].

Chemical compound and disease context of SPIN1

  • Reintroducing dipolar coupling between spin-1/2 nuclei (e.g., (13)C, (15)N) and spin-1 (2)H, using phase-modulated deuterium dephasing pulses, provides a simple and efficient basis for obtaining peptide backbone torsion angles (phi, psi) in specific stable-isotope enriched samples [7].
  • Hypoxia drove the cells to a more anaerobic glycolytic metabolism, increased the rates of glucose consumption (GCR) and lactate production (LPR), and reduced the rates of oxygen consumption (OCR) and insulin secretion (ISR) [8].
  • Other substantial problems in targeting tumour cells with adenoviral vectors are the heterogeneity or lack of expression of coxsackie-adenovirus receptors and integrin co-receptors in ovarian tumours and the presence of adenovirus-neutralising antibodies in ovarian cancer-related ascites [9].
  • In the present study the effectiveness of intravenous atropine sulphate which blocks the peripheral muscarinic receptors at the heart and retrobulbar xylocaine hydrochloride which blocks the conduction at ciliary ganglion on the afferent limb of OCR was studied during strabismus surgery [10].

Biological context of SPIN1

  • This suggests that cessation of recombination at the spindlin locus of the ancestral W and Z chromosomes of the paleognathous tinamiformes and the neognathous avian species were independent events [11].
  • Evolution of the spindlin gene in birds: independent cessation of the recombination of sex chromosomes at the spindlin locus in neognathous birds and tinamous, a palaeognathous avian family [11].
  • This paper describes experiments which show that the sequences of these forms are more similar to each other and to the homologous undifferentiated spindlin gene sequences in the ratite genome than to the W or Z forms of the spindlin gene in other, neognathous species [11].
  • The numerical results are obtained from Monte Carlo studies of the spin-1 Blume-Emery-Griffiths model with spin-exchange kinetics [12].
  • Is the risk of ovarian cancer related to age at menarche and age at menopause [13]?

Anatomical context of SPIN1


Associations of SPIN1 with chemical compounds

  • Identification of Hydrogen Bonds to the Rieske Cluster through the Weakly Coupled Nitrogens Detected by Electron Spin Echo Envelope Modulation Spectroscopy [18].
  • We report muon spin rotation measurements of the local magnetic susceptibility around a positive muon in the paramagnetic state of the quasi-one-dimensional spin 1/2 antiferromagnet dichlorobis (pyridine) copper (II) [19].
  • In this Letter we report exact results on the infrared asymptotics of the one-particle dynamical correlation function of the gas of impenetrable spin 1/2 fermions at infinitesimal temperature [20].
  • The analysis of color-superconducting two-flavor deconfined quark matter at moderate densities is extended to include a particular spin-1 Cooper pairing of those quarks which do not participate in the standard spin-0 diquark condensate [21].
  • We report the low-temperature multifrequency ESR studies of copper pyrimidine dinitrate, a spin-1/2 antiferromagnetic chain with alternating g tensor and the Dzyaloshinskii-Moriya interaction, allowing us to test a new theoretical concept proposed recently by Oshikawa and Affleck [Phys. Rev. Lett. 82, 5136 (1999)] [22].

Other interactions of SPIN1

  • Of the four genes which are known to have diverged copies on the neognathous avian W and Z chromosome (ATP5A1, CHD1, PKC and SPIN) only the spindlin gene has W- and Z-chromosomal forms in the tinamiformes [11].
  • Clinical data capture: OMR and OCR and your flatbed scanner [23].
  • Such a coordinating role of BRCA1 in gene expression may ensure the appropriate quantity and quality of the mature transcripts for certain breast and ovarian cancer-related genes, as well as the genetic integrity of the breast and ovary tissues [24].
  • Our results suggest that peritoneal mesothelial cells may be a prominent source of IL-6 in ovarian cancer-related ascites [25].
  • We have prepared combined electron and nuclear spin pseudoentangled states Psi+/-27 and Phi+/-18 out of the total number of eight quantum states in the multilevel quantum system of a nitrogen atom with electron spin 3/2 and nuclear spin 1/2 encaged in the endohedral fullerene (15)N@C(60) [26].

Analytical, diagnostic and therapeutic context of SPIN1

  • This review presents a perspective on the basic phenomena and manipulations that have made this progress possible and describes the new opportunities and challenges that are being opened in the realms of spin-1/2 and quadrupole nuclei spectroscopies [27].
  • We consider electrons confined to a quantum dot interacting antiferromagnetically with a spin-1 / 2 Kondo impurity [28].
  • The "Dirac cone spectrum" of electrons at the chemical potential of graphite generates our collective mode, so we call this "spin-1 zero sound" of the "Dirac sea." Epithermal neutron scattering experiments and spin polarized electron energy loss spectroscopy can be used to confirm and study our collective mode [29].
  • Neutron diffraction has shown that an applied magnetic field of 5 T is sufficient to induce saturated (3.38(7)mu(B) per Mn) long-range ferromagnetic ordering of the atomic moments at 2 K, and that the induced ordering persists up to a temperature of 50 K in 5 T. Spin glass behavior is observed below 20 K in the absence of an applied field [30].
  • The ratio of chemotherapy combined was 50.1% in PCS and 67.5% in OCR (p = 0.001), 47.4% in PCS NA [31].


  1. Analysis of treatment practices for elderly cancer patients in Ontario, Canada. Townsley, C., Pond, G.R., Peloza, B., Kok, J., Naidoo, K., Dale, D., Herbert, C., Holowaty, E., Straus, S., Siu, L.L. J. Clin. Oncol. (2005) [Pubmed]
  2. Does a centralized radiotherapy system provide adequate access to care? Mackillop, W.J., Groome, P.A., Zhang-Solomons, J., Zhou, Y., Feldman-Stewart, D., Paszat, L., Dixon, P., Holowaty, E.J., Cummings, B.J. J. Clin. Oncol. (1997) [Pubmed]
  3. Hypercorticism blunts circadian variations of osteocalcin regardless of nutritional status. Vergély, N., Lafage-Proust, M.H., Caillot-Augusseau, A., Millot, L., Lang, F., Estour, B. Bone (2002) [Pubmed]
  4. Localised 1H-MR spectroscopy for metabolic characterisation of diffuse and focal brain lesions in patients infected with HIV. Simone, I.L., Federico, F., Tortorella, C., Andreula, C.F., Zimatore, G.B., Giannini, P., Angarano, G., Lucivero, V., Picciola, P., Carrara, D., Bellacosa, A., Livrea, P. J. Neurol. Neurosurg. Psychiatr. (1998) [Pubmed]
  5. Timely translation during the mouse oocyte-to-embryo transition. Oh, B., Hwang, S., McLaughlin, J., Solter, D., Knowles, B.B. Development (2000) [Pubmed]
  6. Spindlin, a major maternal transcript expressed in the mouse during the transition from oocyte to embryo. Oh, B., Hwang, S.Y., Solter, D., Knowles, B.B. Development (1997) [Pubmed]
  7. Peptide torsion angle measurements: effects of nondilute spin pairs on carbon-observed, deuterium-dephased PM5-REDOR. Sack, I., Balazs, Y.S., Rahimipour, S., Vega, S. J. Magn. Reson. (2001) [Pubmed]
  8. Development of a bioartificial pancreas: II. Effects of oxygen on long-term entrapped betaTC3 cell cultures. Papas, K.K., Long, R.C., Sambanis, A., Constantinidis, I. Biotechnol. Bioeng. (1999) [Pubmed]
  9. Why did p53 gene therapy fail in ovarian cancer? Zeimet, A.G., Marth, C. The lancet oncology. (2003) [Pubmed]
  10. Prevention of oculocardiac reflex (O.C.R) during extraocular muscle surgery. Misurya, V.K., Singh, S.P., Kulshrestha, V.K. Indian journal of ophthalmology. (1990) [Pubmed]
  11. Evolution of the spindlin gene in birds: independent cessation of the recombination of sex chromosomes at the spindlin locus in neognathous birds and tinamous, a palaeognathous avian family. de Kloet, R.S., de Kloet, S.R. Genetica (2003) [Pubmed]
  12. Aging and equilibrium fluctuations for domain growth in ternary mixtures. Puri, S., Kumar, D. Phys. Rev. Lett. (2004) [Pubmed]
  13. Is the risk of ovarian cancer related to age at menarche and age at menopause? Kvåle, G., Heuch, I., Nilssen, S. Int. J. Cancer (1992) [Pubmed]
  14. Light-dependent spin trapping of hydroxyl radical from human erythrocytes. Bynoe, L.A., Pou, S., Gottsch, J.D., Rosen, G.M. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  15. Vestibular-neck interaction of human ocular counterroll. Ott, D. Behav. Brain Res. (1992) [Pubmed]
  16. Subcellular distribution of a nitroxide spin-labeled netropsin-acridine hybrid in living KB cells: Electron Spin Resonance Study. Bailly, C., Hénichart, J.P. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  17. Intracellular uptake of anionic superparamagnetic nanoparticles as a function of their surface coating. Wilhelm, C., Billotey, C., Roger, J., Pons, J.N., Bacri, J.C., Gazeau, F. Biomaterials (2003) [Pubmed]
  18. Identification of Hydrogen Bonds to the Rieske Cluster through the Weakly Coupled Nitrogens Detected by Electron Spin Echo Envelope Modulation Spectroscopy. Dikanov, S.A., Kolling, D.R., Endeward, B., Samoilova, R.I., Prisner, T.F., Nair, S.K., Crofts, A.R. J. Biol. Chem. (2006) [Pubmed]
  19. Local magnetic susceptibility of the positive muon in the quasi-one-dimensional S=1/2 antiferromagnet dichlorobis (pyridine) copper (II). Chakhalian, J.A., Kiefl, R.F., Miller, R., Brewer, J., Dunsiger, S.R., Morris, G., MacFarlane, W.A., Sonier, J.E., Eggert, S., Affleck, I., Keren, A., Verdaguer, M. Phys. Rev. Lett. (2003) [Pubmed]
  20. Nonunitary spin-charge separation in a one-dimensional fermion gas. Cheianov, V.V., Zvonarev, M.B. Phys. Rev. Lett. (2004) [Pubmed]
  21. Anisotropic admixture in color-superconducting quark matter. Buballa, M., Hosek, J., Oertel, M. Phys. Rev. Lett. (2003) [Pubmed]
  22. Electron spin resonance in sine-gordon spin chains in the perturbative spinon regime. Zvyagin, S.A., Kolezhuk, A.K., Krzystek, J., Feyerherm, R. Phys. Rev. Lett. (2005) [Pubmed]
  23. Clinical data capture: OMR and OCR and your flatbed scanner. Bergeron, B. MedGenMed [electronic resource] : Medscape general medicine. (2005) [Pubmed]
  24. BRCA1: a locus-specific "liaison" in gene expression and genetic integrity. Aiyar, S., Sun, J.L., Li, R. J. Cell. Biochem. (2005) [Pubmed]
  25. IL-6 secretion by human peritoneal mesothelial and ovarian cancer cells. Offner, F.A., Obrist, P., Stadlmann, S., Feichtinger, H., Klingler, P., Herold, M., Zwierzina, H., Hittmair, A., Mikuz, G., Abendstein, B. Cytokine (1995) [Pubmed]
  26. Pseudoentanglement of spin states in the multilevel 15N@C60 system. Mehring, M., Scherer, W., Weidinger, A. Phys. Rev. Lett. (2004) [Pubmed]
  27. Spin-1/2 and beyond: a perspective in solid state NMR spectroscopy. Frydman, L. Annual review of physical chemistry. (2001) [Pubmed]
  28. Interplay between the mesoscopic Stoner and Kondo effects in quantum dots. Murthy, G. Phys. Rev. Lett. (2005) [Pubmed]
  29. Gapless spin-1 neutral collective mode branch for graphite. Baskaran, G., Jafari, S.A. Phys. Rev. Lett. (2002) [Pubmed]
  30. Chemically induced magnetism and magnetoresistance in La(0.8)Sr(1.2)Mn(0.6)Rh(0.4)O(4). Battle, P.D., Bell, A.M., Blundell, S.J., Coldea, A.I., Cussen, E.J., Hardy, G.C., Marshall, I.M., Rosseinsky, M.J., Steer, C.A. J. Am. Chem. Soc. (2001) [Pubmed]
  31. The Patterns of Care Study and Regional Cancer Registry for non-small-cell lung cancer in Japan. Sugiyama, H., Teshima, T., Ohno, Y., Inoue, T., Takahashi, Y., Oshima, A., Sumi, M., Uno, T., Ikeda, H. Int. J. Radiat. Oncol. Biol. Phys. (2003) [Pubmed]
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