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Ruiz-Vela, A. et al.

Ruiz-Vela, González de Buitrago, Martínez-A,

Nuclear Apaf-1 and cytochrome c redistribution following stress-induced apoptosis.

Apoptotic protease activating factor-1 ( Apaf-1) and cytochrome c are cofactors critical for inducing caspase-9 activation following stress-induced apoptosis. One consequence of caspase-9 activation is nuclear-cytoplasmic barrier disassembly, which is required for nuclear caspase-3 translocation. In the nucleus, caspase-3 triggers proteolysis of the caspase- activated DNA nuclease ( CAD) inhibitor, causing CAD induction and subsequent DNA degradation. Here we demonstrate that apoptotic cells show perinuclear cytochrome c aggregation, which may be critical for nuclear redistribution of cytochrome c and Apaf-1. We thus indicate that the nuclear redistribution of these cofactors concurs with the previously reported caspase-9-induced nuclear disassembly, and may represent an early apoptotic hallmark.[1]

References

Nuclear Apaf-1 and cytochrome c redistribution following stress-induced apoptosis. Ruiz-Vela, A., González de Buitrago, G., Martínez-A, C. FEBS Lett. (2002) [Pubmed]

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