Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Ströbel, P. et al.

Ströbel, Helmreich, Menioudakis, Lewin, Rüdiger, Bauer, Hoffacker, Gold, Nix, Schalke, Elert, Semik, Müller-Hermelink, Marx,

Paraneoplastic myasthenia gravis correlates with generation of mature naive CD4(+) T cells in thymomas.

Myasthenia gravis (MG) is the leading paraneoplastic manifestation of thymomas and is probably related to the capacity of thymomas to mature and export potentially autoreactive T cells. Why some thymomas are MG associated (MG+) and others are not (MG-) has been unclear. We addressed this question by comparing the percentages of intratumorous naive mature CD45RA+ thymocytes in 9 MG(+) and in 13 MG(-) thymomas by fluorescence-activated cell sorting analysis. Our results show that intratumorous naive CD4 T cells were present in all MG(+) thymomas and in one MG(-) thymoma with the development of MG only 2 months after surgery. By contrast, the percentage of naive CD4(+) T cells was significantly reduced in all 13 MG(-) thymomas (P <.0001). Alterations in intratumorous thymopoiesis were reflected by corresponding alterations of naive T-cell subset composition in the blood, in that only MG(-) patients had significantly decreased levels (P =.02) of naive CD4(+) T cells compared with age- and sex-matched control persons. We conclude that paraneoplastic MG is highly associated with the efficiency of thymomas to produce and export naive CD4(+) T cells. The acquisition of the CD45RA(+) phenotype on CD4(+) T cells during terminal intratumorous thymopoiesis is associated with the presence of MG in most thymoma patients.[1]

References

Paraneoplastic myasthenia gravis correlates with generation of mature naive CD4(+) T cells in thymomas. Ströbel, P., Helmreich, M., Menioudakis, G., Lewin, S.R., Rüdiger, T., Bauer, A., Hoffacker, V., Gold, R., Nix, W., Schalke, B., Elert, O., Semik, M., Müller-Hermelink, H.K., Marx, A. Blood (2002) [Pubmed]

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