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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Big G, little G: G proteins and actin cytoskeletal reorganization.

It has been known for some time that stimulation of heterotrimeric G protein-coupled receptors can cause cytoskeletal reorganization. A recent report in Developmental Cell demonstrates that the activation of a tyrosine kinase, C-terminal Src kinase, by heterotrimeric G protein subunits provides the trigger for Rho-dependent actin stress fiber formation.[1]

References

  1. Big G, little G: G proteins and actin cytoskeletal reorganization. Luttrell, L.M. Mol. Cell (2002) [Pubmed]
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