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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

An actin nucleation mechanism mediated by Bni1 and profilin.

Formins are required for cell polarization and cytokinesis, but do not have a defined biochemical activity. In Saccharomyces cerevisiae, formins and the actin-monomer-binding protein profilin are specifically required to assemble linear actin structures called 'actin cables'. These structures seem to be assembled independently of the Arp2/3 complex, the only well characterized cellular mediator of actin nucleation. Here, an activated yeast formin was purified and found to promote the nucleation of actin filaments in vitro. Formin-dependent actin nucleation was stimulated by profilin. Thus, formin and profilin mediate actin nucleation by an Arp2/3-independent mechanism. These findings suggest that distinct actin nucleation mechanisms may underlie the assembly of different actin cytoskeletal structures.[1]


  1. An actin nucleation mechanism mediated by Bni1 and profilin. Sagot, I., Rodal, A.A., Moseley, J., Goode, B.L., Pellman, D. Nat. Cell Biol. (2002) [Pubmed]
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