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Gene Review

IQG1  -  Iqg1p

Saccharomyces cerevisiae S288c

Synonyms: CYK1, Cytokinesis protein 1, IQGAP-related protein 1, Ras GTPase-activating-like protein IQG1, YPL242C
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Disease relevance of IQG1


High impact information on IQG1


Biological context of IQG1


Anatomical context of IQG1


Associations of IQG1 with chemical compounds


Physical interactions of IQG1


Enzymatic interactions of IQG1

  • Towards the end of the cell cycle, the localization of Bud10p refines to a tight double ring which splits at cytokinesis into two single rings, one in each progeny cell [29].
  • In haploids, Bud5 forms double rings that encircle the mother-bud neck and split upon cytokinesis so that each progeny cell inherits Bud5 at the axial division remnant [30].

Co-localisations of IQG1


Regulatory relationships of IQG1


Other interactions of IQG1

  • Iqg1p, a yeast homologue of the mammalian IQGAPs, mediates cdc42p effects on the actin cytoskeleton [35].
  • Iqg1p also appears to specify axial bud-site selection and mediates the proper localization of the septin, Cdc12p, as well as binds and helps localize the secretion landmark, Sec3p [13].
  • The correlation between light chain structure and IQ sequence is demonstrated further by sedimentation velocity analysis of complexes of Mlc1p with IQ motifs from Myo2p and Iqg1p [36].
  • We also show two-hybrid interactions between Iqg1p and Afr1p, a septin-binding protein involved in projection formation (Konopka, J.B., C. DeMattei, and C. Davis. 1995. Mol. Cell. Biol. 15:723-730) [35].
  • Saccharomyces cerevisiae Mob1p is required for cytokinesis and mitotic exit [37].

Analytical, diagnostic and therapeutic context of IQG1


  1. HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes. Chang, F., Re, F., Sebastian, S., Sazer, S., Luban, J. Mol. Biol. Cell (2004) [Pubmed]
  2. Expression of Nedd5, a mammalian septin, in human brain tumors. Sakai, K., Kurimoto, M., Tsugu, A., Hubbard, S.L., Trimble, W.S., Rutka, J.T. J. Neurooncol. (2002) [Pubmed]
  3. The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway. Toda, T., Dhut, S., Superti-Furga, G., Gotoh, Y., Nishida, E., Sugiura, R., Kuno, T. Mol. Cell. Biol. (1996) [Pubmed]
  4. Extrinsic cues, intrinsic cues and microfilaments regulate asymmetric protein localization in Drosophila neuroblasts. Broadus, J., Doe, C.Q. Curr. Biol. (1997) [Pubmed]
  5. Syntaxin 5 is required for cytokinesis and spermatid differentiation in Drosophila. Xu, H., Brill, J.A., Hsien, J., McBride, R., Boulianne, G.L., Trimble, W.S. Dev. Biol. (2002) [Pubmed]
  6. NoCut: cytokinesis in check. Bloom, K. Cell (2006) [Pubmed]
  7. Periodic gene expression program of the fission yeast cell cycle. Rustici, G., Mata, J., Kivinen, K., Lió, P., Penkett, C.J., Burns, G., Hayles, J., Brazma, A., Nurse, P., Bähler, J. Nat. Genet. (2004) [Pubmed]
  8. Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. Herceg, Z., Hulla, W., Gell, D., Cuenin, C., Lleonart, M., Jackson, S., Wang, Z.Q. Nat. Genet. (2001) [Pubmed]
  9. Genes required for ionizing radiation resistance in yeast. Bennett, C.B., Lewis, L.K., Karthikeyan, G., Lobachev, K.S., Jin, Y.H., Sterling, J.F., Snipe, J.R., Resnick, M.A. Nat. Genet. (2001) [Pubmed]
  10. Coronin involved in phagocytosis: dynamics of particle-induced relocalization visualized by a green fluorescent protein Tag. Maniak, M., Rauchenberger, R., Albrecht, R., Murphy, J., Gerisch, G. Cell (1995) [Pubmed]
  11. Sequential assembly of myosin II, an IQGAP-like protein, and filamentous actin to a ring structure involved in budding yeast cytokinesis. Lippincott, J., Li, R. J. Cell Biol. (1998) [Pubmed]
  12. Identification and functional analysis of the essential and regulatory light chains of the only type II myosin Myo1p in Saccharomyces cerevisiae. Luo, J., Vallen, E.A., Dravis, C., Tcheperegine, S.E., Drees, B., Bi, E. J. Cell Biol. (2004) [Pubmed]
  13. Iqg1p links spatial and secretion landmarks to polarity and cytokinesis. Osman, M.A., Konopka, J.B., Cerione, R.A. J. Cell Biol. (2002) [Pubmed]
  14. The multiple roles of Cyk1p in the assembly and function of the actomyosin ring in budding yeast. Shannon, K.B., Li, R. Mol. Biol. Cell (1999) [Pubmed]
  15. A myosin light chain mediates the localization of the budding yeast IQGAP-like protein during contractile ring formation. Shannon, K.B., Li, R. Curr. Biol. (2000) [Pubmed]
  16. Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis. Bi, E., Maddox, P., Lew, D.J., Salmon, E.D., McMillan, J.N., Yeh, E., Pringle, J.R. J. Cell Biol. (1998) [Pubmed]
  17. Mlc1p promotes septum closure during cytokinesis via the IQ motifs of the vesicle motor Myo2p. Wagner, W., Bielli, P., Wacha, S., Ragnini-Wilson, A. EMBO J. (2002) [Pubmed]
  18. The UCS domain protein She4p binds to myosin motor domains and is essential for class I and class V myosin function. Wesche, S., Arnold, M., Jansen, R.P. Curr. Biol. (2003) [Pubmed]
  19. Forchlorfenuron, a phenylurea cytokinin, disturbs septin organization in Saccharomyces cerevisiae. Iwase, M., Okada, S., Oguchi, T., Toh-e, A. Genes Genet. Syst. (2004) [Pubmed]
  20. The budding yeast Ipl1/Aurora protein kinase regulates mitotic spindle disassembly. Buvelot, S., Tatsutani, S.Y., Vermaak, D., Biggins, S. J. Cell Biol. (2003) [Pubmed]
  21. Fungal cell wall septation and cytokinesis are inhibited by bleomycins. Moore, C.W., McKoy, J., Del Valle, R., Armstrong, D., Bernard, E.M., Katz, N., Gordon, R.E. Antimicrob. Agents Chemother. (2003) [Pubmed]
  22. Interaction of casein kinase 1 delta (CK1delta) with post-Golgi structures, microtubules and the spindle apparatus. Behrend, L., Stöter, M., Kurth, M., Rutter, G., Heukeshoven, J., Deppert, W., Knippschild, U. Eur. J. Cell Biol. (2000) [Pubmed]
  23. Septin1, a new interaction partner for human serine/threonine kinase aurora-B. Qi, M., Yu, W., Liu, S., Jia, H., Tang, L., Shen, M., Yan, X., Saiyin, H., Lang, Q., Wan, B., Zhao, S., Yu, L. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  24. Morphogenesis beyond cytokinetic arrest in Saccharomyces cerevisiae. Jiménez, J., Cid, V.J., Cenamor, R., Yuste, M., Molero, G., Nombela, C., Sánchez, M. J. Cell Biol. (1998) [Pubmed]
  25. Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast. Cvrcková, F., De Virgilio, C., Manser, E., Pringle, J.R., Nasmyth, K. Genes Dev. (1995) [Pubmed]
  26. Asymmetric spindle pole localization of yeast Cdc15 kinase links mitotic exit and cytokinesis. Menssen, R., Neutzner, A., Seufert, W. Curr. Biol. (2001) [Pubmed]
  27. Verprolin cytokinesis function mediated by the Hof one trap domain. Ren, G., Wang, J., Brinkworth, R., Winsor, B., Kobe, B., Munn, A.L. Traffic (2005) [Pubmed]
  28. Yeast Nop15p is an RNA-binding protein required for pre-rRNA processing and cytokinesis. Oeffinger, M., Tollervey, D. EMBO J. (2003) [Pubmed]
  29. Bud10p directs axial cell polarization in budding yeast and resembles a transmembrane receptor. Halme, A., Michelitch, M., Mitchell, E.L., Chant, J. Curr. Biol. (1996) [Pubmed]
  30. A localized GTPase exchange factor, Bud5, determines the orientation of division axes in yeast. Marston, A.L., Chen, T., Yang, M.C., Belhumeur, P., Chant, J. Curr. Biol. (2001) [Pubmed]
  31. An IQGAP-related protein controls actin-ring formation and cytokinesis in yeast. Epp, J.A., Chant, J. Curr. Biol. (1997) [Pubmed]
  32. The Bub2-dependent mitotic pathway in yeast acts every cell cycle and regulates cytokinesis. Lee, S.E., Jensen, S., Frenz, L.M., Johnson, A.L., Fesquet, D., Johnston, L.H. J. Cell. Sci. (2001) [Pubmed]
  33. Split decisions: coordinating cytokinesis in yeast. Wolfe, B.A., Gould, K.L. Trends Cell Biol. (2005) [Pubmed]
  34. Dual function of Cyk2, a cdc15/PSTPIP family protein, in regulating actomyosin ring dynamics and septin distribution. Lippincott, J., Li, R. J. Cell Biol. (1998) [Pubmed]
  35. Iqg1p, a yeast homologue of the mammalian IQGAPs, mediates cdc42p effects on the actin cytoskeleton. Osman, M.A., Cerione, R.A. J. Cell Biol. (1998) [Pubmed]
  36. Two distinct myosin light chain structures are induced by specific variations within the bound IQ motifs-functional implications. Terrak, M., Wu, G., Stafford, W.F., Lu, R.C., Dominguez, R. EMBO J. (2003) [Pubmed]
  37. Saccharomyces cerevisiae Mob1p is required for cytokinesis and mitotic exit. Luca, F.C., Mody, M., Kurischko, C., Roof, D.M., Giddings, T.H., Winey, M. Mol. Cell. Biol. (2001) [Pubmed]
  38. Direct evidence for a critical role of myosin II in budding yeast cytokinesis and the evolvability of new cytokinetic mechanisms in the absence of myosin II. Tolliday, N., Pitcher, M., Li, R. Mol. Biol. Cell (2003) [Pubmed]
  39. A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Prokopenko, S.N., Brumby, A., O'Keefe, L., Prior, L., He, Y., Saint, R., Bellen, H.J. Genes Dev. (1999) [Pubmed]
  40. Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae. Yamochi, W., Tanaka, K., Nonaka, H., Maeda, A., Musha, T., Takai, Y. J. Cell Biol. (1994) [Pubmed]
  41. Nuclear envelope fission is linked to cytokinesis in budding yeast. Lippincott, J., Li, R. Exp. Cell Res. (2000) [Pubmed]
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