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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Cytomegalovirus recruitment of cellular kinases to dissolve the nuclear lamina.

The passage of large-sized herpesviral capsids through the nuclear lamina and the inner nuclear membrane to leave the nucleus requires a dissolution of the nuclear lamina. Here, we report on the functions of M50/p35, a beta-herpesviral protein of murine cytomegalovirus. M50/p35 inserts into the inner nuclear membrane and is aggregated by a second viral protein, M53/p38, to form the capsid docking site. M50/p35 recruits the cellular protein kinase C for phosphorylation and dissolution of the nuclear lamina, suggesting that herpesviruses target a critical element of nuclear architecture.[1]


  1. Cytomegalovirus recruitment of cellular kinases to dissolve the nuclear lamina. Muranyi, W., Haas, J., Wagner, M., Krohne, G., Koszinowski, U.H. Science (2002) [Pubmed]
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