The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Herpesviridae


Psychiatry related information on Herpesviridae


High impact information on Herpesviridae


Chemical compound and disease context of Herpesviridae

  • Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry [11].
  • Here we show, for the first time to our knowledge, that latent infection with KSHV in B lymphocytes can be terminated by glycyrrhizic acid (GA), a triterpenoid compound earlier shown to inhibit the lytic replication of other herpesviruses [12].
  • These results suggest that acyclovir-resistant viruses could establish latent infections in clinical settings and have implications for the use of genetically engineered herpesviruses to deliver foreign genes to neurons [13].
  • Strikingly, the glycoprotein B disintegrin-like domain is conserved in many human and animal herpesviruses, suggesting that integrins may support entry across this medically important virus family [14].
  • The relative inability of the EBV-induced DNA polymerase to distinguish between the two purine nucleotides reported here is consistent with previous reports on the ready incorporation of other nucleotide analogs into DNA polymerases induced by other herpesviruses [15].

Biological context of Herpesviridae


Anatomical context of Herpesviridae


Gene context of Herpesviridae

  • The demonstration that distinct herpesviruses target the HVEM-BTLA cosignaling pathway suggests the importance of this pathway in regulating T cell activation during host defenses [26].
  • Importantly, Cdk2 activity is also essential for replication in other human herpesviruses [27].
  • A sequence located between residues 610 and 636 on the UL52 protein was found to be conserved among the UL52 homologues of eight herpesviruses [28].
  • Evolutionary trace analysis of UL25 and its homologues in other herpesviruses was used to locate potentially important amino acids on the surface of the protein, leading to the identification of four putative docking regions for protein partners [29].
  • Our objective is to explore interactions between Luman and HCF and to determine if they play a role in the biology of herpesviruses [30].

Analytical, diagnostic and therapeutic context of Herpesviridae


  1. Lytic KSHV infection inhibits host gene expression by accelerating global mRNA turnover. Glaunsinger, B., Ganem, D. Mol. Cell (2004) [Pubmed]
  2. A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae. Kattenhorn, L.M., Korbel, G.A., Kessler, B.M., Spooner, E., Ploegh, H.L. Mol. Cell (2005) [Pubmed]
  3. Related functional domains in virus DNA polymerases. Larder, B.A., Kemp, S.D., Darby, G. EMBO J. (1987) [Pubmed]
  4. G-protein-coupled receptors encoded by human herpesviruses. Couty, J.P., Gershengorn, M.C. Trends Pharmacol. Sci. (2005) [Pubmed]
  5. Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek's disease virus. Brown, A.C., Baigent, S.J., Smith, L.P., Chattoo, J.P., Petherbridge, L.J., Hawes, P., Allday, M.J., Nair, V. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  6. Cytomegalovirus is present in a very high proportion of brains from vascular dementia patients. Lin, W.R., Wozniak, M.A., Wilcock, G.K., Itzhaki, R.F. Neurobiol. Dis. (2002) [Pubmed]
  7. Three-dimensional structure of human cytomegalovirus protease. Shieh, H.S., Kurumbail, R.G., Stevens, A.M., Stegeman, R.A., Sturman, E.J., Pak, J.Y., Wittwer, A.J., Palmier, M.O., Wiegand, R.C., Holwerda, B.C., Stallings, W.C. Nature (1996) [Pubmed]
  8. A gene for dihydrofolate reductase in a herpesvirus. Trimble, J.J., Murthy, S.C., Bakker, A., Grassmann, R., Desrosiers, R.C. Science (1988) [Pubmed]
  9. Signaling by human herpesvirus 8 kaposin A through direct membrane recruitment of cytohesin-1. Kliche, S., Nagel, W., Kremmer, E., Atzler, C., Ege, A., Knorr, T., Koszinowski, U., Kolanus, W., Haas, J. Mol. Cell (2001) [Pubmed]
  10. A secreted chemokine binding protein encoded by murine gammaherpesvirus-68 is necessary for the establishment of a normal latent load. Bridgeman, A., Stevenson, P.G., Simas, J.P., Efstathiou, S. J. Exp. Med. (2001) [Pubmed]
  11. Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry. Shukla, D., Spear, P.G. J. Clin. Invest. (2001) [Pubmed]
  12. Glycyrrhizic acid alters Kaposi sarcoma-associated herpesvirus latency, triggering p53-mediated apoptosis in transformed B lymphocytes. Curreli, F., Friedman-Kien, A.E., Flore, O. J. Clin. Invest. (2005) [Pubmed]
  13. Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate. Coen, D.M., Kosz-Vnenchak, M., Jacobson, J.G., Leib, D.A., Bogard, C.L., Schaffer, P.A., Tyler, K.L., Knipe, D.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  14. Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain. Feire, A.L., Koss, H., Compton, T. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  15. Incorporation into DNA of the base analog 2-aminopurine by the Epstein-Barr virus-induced DNA polymerase in vivo and in vitro. Grossberger, D., Clough, W. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  16. TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues. Teitell, M., Damore, M.A., Sulur, G.G., Turner, D.E., Stern, M.H., Said, J.W., Denny, C.T., Wall, R. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  17. Neonatal infection with mouse thymic virus: effects on cells regulating the antibody response to type III pneumococcal polysaccharide. Morse, H.C., Cross, S.S., Baker, P.J. J. Immunol. (1976) [Pubmed]
  18. A single amino acid substitution abolishes feedback inhibition of vaccinia virus thymidine kinase. Black, M.E., Hruby, D.E. J. Biol. Chem. (1992) [Pubmed]
  19. Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Gorbalenya, A.E., Koonin, E.V., Donchenko, A.P., Blinov, V.M. Nucleic Acids Res. (1989) [Pubmed]
  20. Glycoproteins M and N of pseudorabies virus form a disulfide-linked complex. Jöns, A., Dijkstra, J.M., Mettenleiter, T.C. J. Virol. (1998) [Pubmed]
  21. A seek-and-hide game between Cd1-restricted T cells and herpesviruses. Hegde, N.R., Johnson, D.C. J. Clin. Invest. (2005) [Pubmed]
  22. Nucleotide sequence and predicted amino acid sequence of a protein encoded in a small herpes simplex virus DNA fragment capable of trans-inducing alpha genes. Pellett, P.E., McKnight, J.L., Jenkins, F.J., Roizman, B. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  23. Detection of herpesviruses by polymerase chain reaction in lymphocytes from patients with rheumatoid arthritis. Zhang, L., Nikkari, S., Skurnik, M., Ziegler, T., Luukkainen, R., Möttönen, T., Toivanen, P. Arthritis Rheum. (1993) [Pubmed]
  24. Human cytomegalovirus glycoprotein H/glycoprotein L complex modulates fusion-from-without. Milne, R.S., Paterson, D.A., Booth, J.C. J. Gen. Virol. (1998) [Pubmed]
  25. Hematogenously spread herpesviruses are detected as frequently as neuronally spread herpesviruses in cerebrospinal fluid by polymerase chain reaction assay. Studahl, M., Hagberg, L., Rekabdar, E., Bergström, T. Clin. Infect. Dis. (1999) [Pubmed]
  26. Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. Cheung, T.C., Humphreys, I.R., Potter, K.G., Norris, P.S., Shumway, H.M., Tran, B.R., Patterson, G., Jean-Jacques, R., Yoon, M., Spear, P.G., Murphy, K.M., Lurain, N.S., Benedict, C.A., Ware, C.F. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  27. KSHV G protein-coupled receptor inhibits lytic gene transcription in primary-effusion lymphoma cells via p21-mediated inhibition of Cdk2. Cannon, M., Cesarman, E., Boshoff, C. Blood (2006) [Pubmed]
  28. Identification of the primase active site of the herpes simplex virus type 1 helicase-primase. Dracheva, S., Koonin, E.V., Crute, J.J. J. Biol. Chem. (1995) [Pubmed]
  29. Structural characterization of the UL25 DNA-packaging protein from herpes simplex virus type 1. Bowman, B.R., Welschhans, R.L., Jayaram, H., Stow, N.D., Preston, V.G., Quiocho, F.A. J. Virol. (2006) [Pubmed]
  30. Potential role for luman, the cellular homologue of herpes simplex virus VP16 (alpha gene trans-inducing factor), in herpesvirus latency. Lu, R., Misra, V. J. Virol. (2000) [Pubmed]
  31. Malignant catarrhal fever-like disease in Barbary red deer (Cervus elaphus barbarus) naturally infected with a virus resembling alcelaphine herpesvirus 2. Klieforth, R., Maalouf, G., Stalis, I., Terio, K., Janssen, D., Schrenzel, M. J. Clin. Microbiol. (2002) [Pubmed]
  32. The effect of phosphonoacetic acid on the ultrastructure of cell cultures infected with simian oncogenic herpesviruses. King, N.W., Barahona, H., Daniel, M.D., Bekesi, G., Jones, T.C. Lab. Invest. (1978) [Pubmed]
  33. Detection of human cytomegalovirus, Epstein-Barr virus, and herpes simplex virus in diffuse interstitial pneumonia by polymerase chain reaction and immunohistochemistry. Oda, Y., Katsuda, S., Okada, Y., Kawahara, E.I., Ooi, A., Kawashima, A., Nakanishi, I. Am. J. Clin. Pathol. (1994) [Pubmed]
  34. Amplification and characterization of herpesvirus DNA in cerebrospinal fluid from patients with acute encephalitis. Rozenberg, F., Lebon, P. J. Clin. Microbiol. (1991) [Pubmed]
  35. Herpesvirus type 1-8 in BAL fluid from HIV-1-infected patients with suspected pneumonia and from healthy individuals. Tarp, B., Jensen-Fangel, S., Dahl, R., Obel, N. Eur. Respir. J. (2001) [Pubmed]
WikiGenes - Universities