Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Forsberg, R. et al.

The genetic diversity of European type PRRSV is similar to that of the North American type but is geographically skewed within Europe.

Porcine reproductive and respiratory syndrome virus (PRRSV) is a recently emerged pathogen. Two PRRSV genotypes exist, North American and European, which are only 55-70% identical at the nucleotide level. Previous studies have shown high nucleotide diversity in the North American genotype and low nucleotide diversity in the European genotype. Here, we analyzed the ORF5 and ORF7 genes for a large number of new European type PRRSV isolates in conjunction with existing database sequences. This new analysis showed that contrary to previous assumptions, genetic diversity is at least as high in the European genotype as in the North American genotype. Furthermore, we showed that genetic diversity of European type PRRSV has a marked geographical pattern, with exceptionally high genetic diversity among Italian sequences. The geographical pattern of diversity in relation to the epidemiology of PRRSV in Europe is discussed. Discrepancies between ORF5- and ORF7-based genealogies were observed, and further analysis of the data set confirmed the presence of recombination. We were therefore able to report the first observation of recombination in wild-type isolates of European genotype PRRSV.[1]

References

The genetic diversity of European type PRRSV is similar to that of the North American type but is geographically skewed within Europe. Forsberg, R., Storgaard, T., Nielsen, H.S., Oleksiewicz, M.B., Cordioli, P., Sala, G., Hein, J., Bøtner, A. Virology (2002) [Pubmed]

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