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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Differential Pax6 promoter activity and transcript expression during forebrain development.

Three different Pax6 promoters -- P0, P1, and P alpha -- show differential activity in the developing eye and spinal cord. To examine promoter usage during forebrain development, we performed in situ hybridization and reverse transcription-polymerase chain reaction to detect transcripts initiated from each promoter. Promoter-specific transcripts are expressed within subdomains of total Pax6 expression, but differ from one another in their spatial localization and expression over time. Additionally, we identified a novel P0-initiated transcript and detected a developmentally regulated antisense transcript.[1]


  1. Differential Pax6 promoter activity and transcript expression during forebrain development. Anderson, T.R., Hedlund, E., Carpenter, E.M. Mech. Dev. (2002) [Pubmed]
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