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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Influence of ketamine on human plasma cholinesterase.

The influence of ketamine upon human plasma cholinesterase (E.C. was determined by means of a colorimetric assay technique at 25 degrees C, pH 7.7 with butyrylthiocholine as substrate. Ketamine caused a reversible inhibition of cholinesterase (pI50= 2.75; apparent Ki=4.94X10(-4) M). The kinetic analysis of the inhibitory action revealed a mixed competitive/non-competitive type of mechanism with a prevalence of the non-competitive component (alpha-value = 4.9). A decrease in cholinesterase activity is thought to be a result of conformational change of the enzyme protein which is induced by a reversible binding of ketamine to anionic side receptors in the vicinity of the active centre.[1]


  1. Influence of ketamine on human plasma cholinesterase. Schuh, F.T. British journal of anaesthesia. (1975) [Pubmed]
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