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Chemical Compound Review

BUTYRYLTHIOCHOLINE     2-butanoylsulfanylethyl- trimethyl-azanium

Synonyms: CHEMBL139908, AG-F-58114, CHEBI:41055, AC1L2GSR, CTK4I8879, ...
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Disease relevance of BUTYRYLTHIOCHOLINE


High impact information on BUTYRYLTHIOCHOLINE


Biological context of BUTYRYLTHIOCHOLINE

  • Furthermore, the Drosophila enzyme hydrolyzed butyrylthiocholine much more efficiently than these eel or human enzymes, an indication that the fly head enzyme has a substrate specificity intermediate between mammalian acetylcholinesterases and butyrylcholinesterases [7].
  • For this purpose, the kinetics of butyrylthiocholine (BTC) hydrolysis by wild-type human BuChE, by selected mutants and by horse BuChE was carried out at 25 degreeC and pH 7.0 in the presence of tetraethylammonium (TEA) [8].

Anatomical context of BUTYRYLTHIOCHOLINE


Associations of BUTYRYLTHIOCHOLINE with other chemical compounds




  1. Assay using succinyldithiocholine as substrate: the method of choice for the measurement of cholinesterase catalytic activity in serum to diagnose succinyldicholine sensitivity. Mosca, A., Bonora, R., Ceriotti, F., Franzini, C., Lando, G., Patrosso, M.C., Zaninotto, M., Panteghini, M. Clin. Chem. Lab. Med. (2003) [Pubmed]
  2. Intramolecular relationships in cholinesterases revealed by oocyte expression of site-directed and natural variants of human BCHE. Neville, L.F., Gnatt, A., Loewenstein, Y., Seidman, S., Ehrlich, G., Soreq, H. EMBO J. (1992) [Pubmed]
  3. Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis. Harel, M., Sussman, J.L., Krejci, E., Bon, S., Chanal, P., Massoulié, J., Silman, I. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  4. Cloning, expression, and properties of a nonneuronal secreted acetylcholinesterase from the parasitic nematode Nippostrongylus brasiliensis. Hussein, A.S., Chacón, M.R., Smith, A.M., Tosado-Acevedo, R., Selkirk, M.E. J. Biol. Chem. (1999) [Pubmed]
  5. Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket. Ordentlich, A., Barak, D., Kronman, C., Flashner, Y., Leitner, M., Segall, Y., Ariel, N., Cohen, S., Velan, B., Shafferman, A. J. Biol. Chem. (1993) [Pubmed]
  6. Organophosphorus acid anhydride hydrolase activity in human butyrylcholinesterase: synergy results in a somanase. Millard, C.B., Lockridge, O., Broomfield, C.A. Biochemistry (1998) [Pubmed]
  7. Isolation and characterization of acetylcholinesterase from Drosophila. Gnagey, A.L., Forte, M., Rosenberry, T.L. J. Biol. Chem. (1987) [Pubmed]
  8. Concentration-dependent reversible activation-inhibition of human butyrylcholinesterase by tetraethylammonium ion. Stojan, J., Golicnik, M., Froment, M.T., Estour, F., Masson, P. Eur. J. Biochem. (2002) [Pubmed]
  9. Chimeric human cholinesterase. Identification of interaction sites responsible for recognition of acetyl- or butyrylcholinesterase-specific ligands. Loewenstein, Y., Gnatt, A., Neville, L.F., Soreq, H. J. Mol. Biol. (1993) [Pubmed]
  10. Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation. Wierdl, M., Morton, C.L., Danks, M.K., Potter, P.M. Biochem. Pharmacol. (2000) [Pubmed]
  11. Acetylcholinesterase and butyrylcholinesterase measurement in the pre-natal detection of neural tube defects and other fetal malformations. Bonham, J.R., Gowenlock, A.H., Timothy, J.A. Clin. Chim. Acta (1981) [Pubmed]
  12. An inhibitor-free assay of acetylcholinesterase and butyrylcholinesterase in the cerebrospinal fluid. Kluge, H.H., Kluge, W.H., Hartmann, W. Clin. Chim. Acta (1999) [Pubmed]
  13. Ultrastructural localization of non-specific cholinesterase activity in rat muscle spindles. Dubový, P., Soukup, T. Acta Histochem. (1987) [Pubmed]
  14. Pseudocholinesterase activity and its origin in human oral fluid. Ryhänen, R., Närhi, M., Puhakainen, E., Hänninen, O., Kontturi-Närhi, V. J. Dent. Res. (1983) [Pubmed]
  15. Aprophen: a substrate and inhibitor of butyrylcholinesterase and carboxylesterases. Rush, R.S., Ralston, J.S., Wolfe, A.D. Biochem. Pharmacol. (1985) [Pubmed]
  16. Acetylcholinesterase in Dendrobaena veneta (Oligochaeta: Opisthopora) is present with forms sensitive and insensitive to phosphatidylinositol phospholipase C. Biochemical characterization and histochemical localization in the nervous system. Talesa, V., Romani, R., Rosi, G., Giovannini, E. Eur. J. Biochem. (1996) [Pubmed]
  17. Influence of ketamine on human plasma cholinesterase. Schuh, F.T. British journal of anaesthesia. (1975) [Pubmed]
  18. Human plasma carboxylesterase and butyrylcholinesterase enzyme activity: correlations with SN-38 pharmacokinetics during a prolonged infusion of irinotecan. Guemei, A.A., Cottrell, J., Band, R., Hehman, H., Prudhomme, M., Pavlov, M.V., Grem, J.L., Ismail, A.S., Bowen, D., Taylor, R.E., Takimoto, C.H. Cancer Chemother. Pharmacol. (2001) [Pubmed]
  19. Acetylcholinesterase of Schistosoma mansoni: purification and characterization. Goldlust, A., Arnon, R., Silman, I., Tarrab-Hazdai, R. J. Neurosci. Res. (1986) [Pubmed]
  20. A distinct family of acetylcholinesterases is secreted by Nippostrongylus brasiliensis. Hussein, A.S., Harel, M., Selkirk, M.E. Mol. Biochem. Parasitol. (2002) [Pubmed]
  21. Use of whole blood for spectrophotometric determination of cholinesterase activity in dogs. Tecles, F., Martínez Subiela, S., Bernal, L.J., Cerón, J.J. Vet. J. (2000) [Pubmed]
  22. Determination of whole blood cholinesterase in different animal species using specific substrates. Tecles, F., Cerón, J.J. Res. Vet. Sci. (2001) [Pubmed]
  23. Partial purification and characterization of soluble isoform of butyrylcholinesterase from rat intestine. Yildiz, O., Bodur, E., Cokuğraş, A.N., Ozer, N. Protein J. (2004) [Pubmed]
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