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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Characterization of Mycotypha metabolites found to be inhibitors of cell adhesion molecules.

Three inhibitors of cell adhesion based on LFA-1/ICAM-1 were isolated from the cultured broth of the fungal strain Mycotypha sp. UMF-006. These compounds were identified by spectroscopy to be cytochalasin E (1), 5,6-dehydro-7-hydroxy derivative of cytochalasin E (2) and delta 6,12-isomer of 2 (3). All these components inhibited adhesion of HL-60 cells to CHO-ICAM-1 cells at IC50 values of 30 micrograms/ml for 1, 75 micrograms/ml for 2, and 90 micrograms/ml for 3.[1]

References

  1. Characterization of Mycotypha metabolites found to be inhibitors of cell adhesion molecules. Takamatsu, S., Zhang, Q., Schrader, K.K., elSohly, H.N., Walker, L.A. J. Antibiot. (2002) [Pubmed]
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