The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ICAM1  -  intercellular adhesion molecule 1

Homo sapiens

Synonyms: BB2, CD54, ICAM-1, Intercellular adhesion molecule 1, Major group rhinovirus receptor, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ICAM1

  • Although genetic variants in ICAM5 showed the strongest association with disease status, ICAM1 is expressed at highest levels in normal and tumor breast tissue [1].
  • Nevertheless, the simian EBV LMP1s retain most functions in common with EBV LMP1, including the ability to induce NF-(kappa)B activity in human cells, to bind the tumor necrosis factor-associated factor 3 (TRAF3) in vitro, and to induce expression of tumor necrosis factor-responsive genes, such as ICAM1, in human B lymphocytes [2].
  • ICAM1 expression by keratinocytes was observed only in intensely infiltrated lesions of condylomas and laryngeal papillomas [3].
  • CONCLUSIONS: The expression of ICAM1, E-selectin, and TNF alpha allows an assessment of the activity of the vasculitic process in rheumatoid vasculitis [4].
  • We found that ICAM1 SNPs, -9A/C (rs5490) and K469E (rs5498) were associated with prostate cancer risk in men with a family history of prostate cancer (P = 0.008) [5].
  • We targeted recombinant human acid sphingomyelinase (ASM), deficient in types A and B Niemann-Pick disease, to ICAM-1 by loading this enzyme to nanocarriers coated with anti-ICAM [6].
  • EC activation with ICAM-1 expression could contribute to the multiorgan involvement, including the development of myositis and ILD, in patients carrying anti-Jo-1 autoantibodies [7].

Psychiatry related information on ICAM1


High impact information on ICAM1

  • Endothelial members of the immunoglobulin superfamily including ICAM-1 and VCAM-1/INCAM-110 bind to leukocyte cell-surface integrins [13].
  • Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation [14].
  • Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway [15].
  • Using an affinity chromatography purification strategy, genetically engineered transfectants, and direct binding studies to the isolated recombinant protein, we identified a novel hematopoietic fibrinogen receptor participating in this adhesion pathway as intercellular adhesion molecule 1 (ICAM-1) [15].
  • Since cytoadherence to postcapillary venular endothelium is thought to be a major factor in the virulence of P. falciparum malaria, we have examined the interaction between ICAM-1 and the P. falciparum-infected cell, and have compared it with the interaction to the physiological counter receptor, the leukocyte integrin LFA-1 [16].

Chemical compound and disease context of ICAM1


Biological context of ICAM1

  • Blocking experiments with specific MoAbs demonstrated that the cytolytic activity of gamma delta T cells was non-major histocompatibility complex (MHC) restricted and did not involve the gamma delta T-cell antigen receptor (TCR) but that cytolytic activity was dependent on LFA-1 beta/ICAM1 interaction [22].
  • We observed that ICAM1 downregulation at the mRNA and protein levels led to a strong suppression of human breast cell invasion through a matrigel matrix [23].
  • Incubation of cells with an antibody against ICAM1 blocked invasion of the highly metastatic MDA-MB-435 cell line in a dose-dependent manner without affecting cell migration [23].
  • In brain tumors and inflammatory brain lesions, we observed an up-regulation of endothelial ICAM1 and LFA3 expression, whereas other adhesion molecules on endothelial cells remained unchanged [24].
  • This sequence mapped to the p13.2-p13.3 region of chromosome 19, close to the ICAM1 gene chromosomal location [25].

Anatomical context of ICAM1

  • Again, LFA1/ICAM1 interaction plays a key role in NK/BMSC interaction; this interaction is followed by a strong intracellular calcium increase in NK cells [26].
  • Among them, ICAM1, a ligand for the lymphocyte function-associated antigen (FLA1) of leucocytes, may be expressed by antigen-presenting cells and keratinocytes in various inflammatory disorders [3].
  • Its induction was usually correlated with the presence of LFA1-positive cells (mainly CD8-positive cells) which were in close apposition to ICAM1-positive proliferative epithelial cells expressing also, in some cases, HLA-DR antigen [3].
  • In moderately infiltrated lesions, keratinocytes did not express ICAM1, and LFA1-positive cells were not observed in the epidermis [3].
  • In all lesions, ICAM1 was more intense on endothelial cells than in normal skin; infiltrating cells (lymphocytes and dendritic cells) may also express this antigen but intraepithelial Langerhans cells were devoid of any labelling [3].

Associations of ICAM1 with chemical compounds


Physical interactions of ICAM1


Enzymatic interactions of ICAM1

  • The objective of this study was to investigate whether or not cross-linking ICAM-1 on the surface of airway epithelial cells phosphorylated MAP kinases or stimulated chemokine expression and secretion [37].

Co-localisations of ICAM1

  • ICAM-1 expression on follicular epithelium co-localized with intraepithelial mononuclear cells (MNC) positive for the interleukin-2 receptor alpha-chain (IL-2R) or HLA-DR [38].

Regulatory relationships of ICAM1

  • TNF increased VCAM-1 expression to 4.2 times the vehicle-treated control levels (P < .05) on HT-29 cells and increased ICAM-1 expression on HT-29, LoVo, and SW-620 cells (8.4, 1.8, and 1.9 times vehicle control levels, respectively; P < .05 in each case) [39].
  • Interleukin-4 induces homotypic aggregation of human mast cells by promoting LFA-1/ICAM-1 adhesion molecules [33].
  • In previous investigations, we have demonstrated that increased monocyte-derived MIP-1 alpha production was induced by intracellular adhesion molecule-1 (ICAM-1) interactions on activated HUVECs [40].
  • IFN gamma- and IL-6-induced ICAM-1 mRNA synthesis was not different from unstimulated A549 cells [41].
  • Between 3 and 6 hours in the A549 cells, IL-1 beta stimulated the greatest increase in ICAM-1 mRNA, followed by TNF alpha [41].
  • Clustering of ICAM-1 promotes the ICAM-1-filamin B interaction [42].

Other interactions of ICAM1


Analytical, diagnostic and therapeutic context of ICAM1


  1. Large-scale association study identifies ICAM gene region as breast and prostate cancer susceptibility locus. Kammerer, S., Roth, R.B., Reneland, R., Marnellos, G., Hoyal, C.R., Markward, N.J., Ebner, F., Kiechle, M., Schwarz-Boeger, U., Griffiths, L.R., Ulbrich, C., Chrobok, K., Forster, G., Praetorius, G.M., Meyer, P., Rehbock, J., Cantor, C.R., Nelson, M.R., Braun, A. Cancer Res. (2004) [Pubmed]
  2. Comparative analysis identifies conserved tumor necrosis factor receptor-associated factor 3 binding sites in the human and simian Epstein-Barr virus oncogene LMP1. Franken, M., Devergne, O., Rosenzweig, M., Annis, B., Kieff, E., Wang, F. J. Virol. (1996) [Pubmed]
  3. Epidermotropism of T cells correlates with intercellular adhesion molecule (ICAM1) expression in human papillomavirus (HPV)-induced lesions. Viac, J., Chardonnet, Y., Euvrard, S., Schmitt, D. J. Pathol. (1992) [Pubmed]
  4. ICAM-1, E-selectin, and TNF alpha expression in labial salivary glands of patients with rheumatoid vasculitis. Flipo, R.M., Cardon, T., Copin, M.C., Vandecandelaere, M., Duquesnoy, B., Janin, A. Ann. Rheum. Dis. (1997) [Pubmed]
  5. ICAM gene cluster SNPs and prostate cancer risk in African Americans. Chen, H., Hernandez, W., Shriver, M.D., Ahaghotu, C.A., Kittles, R.A. Hum. Genet. (2006) [Pubmed]
  6. Lysosomal enzyme delivery by ICAM-1-targeted nanocarriers bypassing glycosylation- and clathrin-dependent endocytosis. Muro, S., Schuchman, E.H., Muzykantov, V.R. Mol. Ther. (2006) [Pubmed]
  7. Sera from anti-Jo-1-positive patients with polymyositis and interstitial lung disease induce expression of intercellular adhesion molecule 1 in human lung endothelial cells. Barbasso Helmers, S., Englund, P., Engström, M., Ahlin, E., Fathi, M., Janciauskiene, S., Heimbürger, M., Rönnelid, J., Lundberg, I.E. Arthritis Rheum. (2009) [Pubmed]
  8. Vascular cell adhesion molecule 1 (CD106) on primary human articular chondrocytes: functional regulation of expression by cytokines and comparison with intercellular adhesion molecule 1 (CD54) and very late activation antigen 2. Kienzle, G., von Kempis, J. Arthritis Rheum. (1998) [Pubmed]
  9. Crucial role of inhibitor of DNA binding/differentiation in the vascular endothelial growth factor-induced activation and angiogenic processes of human endothelial cells. Sakurai, D., Tsuchiya, N., Yamaguchi, A., Okaji, Y., Tsuno, N.H., Kobata, T., Takahashi, K., Tokunaga, K. J. Immunol. (2004) [Pubmed]
  10. Acute psychological stress and exercise and changes in peripheral leukocyte adhesion molecule expression and density. Goebel, M.U., Mills, P.J. Psychosomatic medicine. (2000) [Pubmed]
  11. Absence of association between an intercellular adhesion molecule 1 gene E469K polymorphism and Alzheimer's disease in Finnish patients. Mattila, K.M., Hiltunen, M., Rinne, J.O., Mannermaa, A., Röyttä, M., Alafuzoff, I., Laippala, P., Soininen, H., Lehtimäki, T. Neurosci. Lett. (2003) [Pubmed]
  12. Chronic alcohol consumption increases serum levels of circulating endothelial cell/leucocyte adhesion molecules E-selectin and ICAM-1. Sacanella, E., Estruch, R., Badía, E., Fernández-Sola, J., Nicolás, J.M., Urbano-Márquez, A. Alcohol Alcohol. (1999) [Pubmed]
  13. Endothelial-leukocyte adhesion molecules. Bevilacqua, M.P. Annu. Rev. Immunol. (1993) [Pubmed]
  14. Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Shimaoka, M., Xiao, T., Liu, J.H., Yang, Y., Dong, Y., Jun, C.D., McCormack, A., Zhang, R., Joachimiak, A., Takagi, J., Wang, J.H., Springer, T.A. Cell (2003) [Pubmed]
  15. Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway. Languino, L.R., Plescia, J., Duperray, A., Brian, A.A., Plow, E.F., Geltosky, J.E., Altieri, D.C. Cell (1993) [Pubmed]
  16. The binding site on ICAM-1 for Plasmodium falciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1-binding site. Berendt, A.R., McDowall, A., Craig, A.G., Bates, P.A., Sternberg, M.J., Marsh, K., Newbold, C.I., Hogg, N. Cell (1992) [Pubmed]
  17. Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages. Kol, A., Bourcier, T., Lichtman, A.H., Libby, P. J. Clin. Invest. (1999) [Pubmed]
  18. Antiinflammatory effects of glucocorticoids in brain cells, independent of NF-kappa B. Bourke, E., Moynagh, P.N. J. Immunol. (1999) [Pubmed]
  19. Activation of nuclear factor-kappa B and gene expression in human endothelial cells by the common haptens nickel and cobalt. Goebeler, M., Roth, J., Bröcker, E.B., Sorg, C., Schulze-Osthoff, K. J. Immunol. (1995) [Pubmed]
  20. Distribution of immunoglobulin superfamily members ICAM-1, -2, -3, and the beta 2 integrin LFA-1 in multiple sclerosis lesions. Bö, L., Peterson, J.W., Mørk, S., Hoffman, P.A., Gallatin, W.M., Ransohoff, R.M., Trapp, B.D. J. Neuropathol. Exp. Neurol. (1996) [Pubmed]
  21. Enhanced activation of rhesus T cells by vectors encoding a triad of costimulatory molecules (B7-1, ICAM-1, LFA-3). Shankar, P., Schlom, J., Hodge, J.W. Vaccine (2001) [Pubmed]
  22. Comparison of cytolytic and proliferative activities of human gamma delta and alpha beta T cells from peripheral blood against various human tumor cell lines. Ensslin, A.S., Formby, B. J. Natl. Cancer Inst. (1991) [Pubmed]
  23. Role of ICAM1 in invasion of human breast cancer cells. Rosette, C., Roth, R.B., Oeth, P., Braun, A., Kammerer, S., Ekblom, J., Denissenko, M.F. Carcinogenesis (2005) [Pubmed]
  24. Expression of leucocyte adhesion molecules at the human blood-brain barrier (BBB). Rössler, K., Neuchrist, C., Kitz, K., Scheiner, O., Kraft, D., Lassmann, H. J. Neurosci. Res. (1992) [Pubmed]
  25. The human intercellular adhesion molecule 3 (ICAM3) gene is located in the 19p13.2-p13.3 region, close to the ICAM1 gene. Bossy, D., Mattei, M.G., Simmons, D.L. Genomics (1994) [Pubmed]
  26. Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: role of NKp30 and NKG2D receptors. Poggi, A., Prevosto, C., Massaro, A.M., Negrini, S., Urbani, S., Pierri, I., Saccardi, R., Gobbi, M., Zocchi, M.R. J. Immunol. (2005) [Pubmed]
  27. Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction. Hassan, A., Hunt, B.J., O'Sullivan, M., Bell, R., D'Souza, R., Jeffery, S., Bamford, J.M., Markus, H.S. Brain (2004) [Pubmed]
  28. Haplotype-based association analysis of 56 functional candidate genes in the IBD6 locus on chromosome 19. Tello-Ruiz, M.K., Curley, C., DelMonte, T., Giallourakis, C., Kirby, A., Miller, K., Wild, G., Cohen, A., Langelier, D., Latiano, A., Wedemeyer, N., Lander, E., Schreiber, S., Annese, V., Daly, M.J., Rioux, J.D. Eur. J. Hum. Genet. (2006) [Pubmed]
  29. Inhibition of adhesion molecule expression on human venous endothelial cells by non-viral siRNA transfection. Walker, T., Wendel, H.P., Tetzloff, L., Raabe, C., Heidenreich, O., Simon, P., Scheule, A.M., Ziemer, G. J. Cell. Mol. Med. (2007) [Pubmed]
  30. Effect of vascular stent alloys on expression of cellular adhesion molecules by endothelial cells. Messer, R.L., Wataha, J.C., Lewis, J.B., Lockwood, P.E., Caughman, G.B., Tseng, W.Y. Journal of long-term effects of medical implants. (2005) [Pubmed]
  31. The pathobiology of bronchial asthma. Arm, J.P., Lee, T.H. Adv. Immunol. (1992) [Pubmed]
  32. Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin binding surface in the ICAM subfamily. Casasnovas, J.M., Pieroni, C., Springer, T.A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  33. Interleukin-4 induces homotypic aggregation of human mast cells by promoting LFA-1/ICAM-1 adhesion molecules. Toru, H., Kinashi, T., Ra, C., Nonoyama, S., Yata, J., Nakahata, T. Blood (1997) [Pubmed]
  34. Adhesion of activated T lymphocytes to vascular smooth muscle cells and dermal fibroblasts is mediated by beta 1- and beta 2-integrins. Stemme, S., Patarroyo, M., Hansson, G.K. Scand. J. Immunol. (1992) [Pubmed]
  35. Regulation of adhesion molecule expression in Kaposi's sarcoma cells. Yang, J., Xu, Y., Zhu, C., Hagan, M.K., Lawley, T., Offermann, M.K. J. Immunol. (1994) [Pubmed]
  36. Epitope mapping of monoclonal antibody to integrin alphaL beta2 hybrid domain suggests different requirements of affinity states for intercellular adhesion molecules (ICAM)-1 and ICAM-3 binding. Tang, R.H., Tng, E., Law, S.K., Tan, S.M. J. Biol. Chem. (2005) [Pubmed]
  37. Selective regulation of MAP kinases and chemokine expression after ligation of ICAM-1 on human airway epithelial cells. Krunkosky, T.M., Jarrett, C.L. Respir. Res. (2006) [Pubmed]
  38. E-selectin and interleukin-2 receptor alpha-chain expression in alopecia universalis. Rilo, H.L., Carroll, P.B., Subbotin, V., Johnson, N., Van Thiel, D.H., Thomson, A.W. Acta Derm. Venereol. (1994) [Pubmed]
  39. Levamisole effects on major histocompatibility complex and adhesion molecule expression and on myeloid cell adhesion to human colon tumor cell lines. Kimball, E.S., Fisher, M.C. J. Natl. Cancer Inst. (1996) [Pubmed]
  40. Production of chemokines, interleukin-8 and monocyte chemoattractant protein-1, during monocyte: endothelial cell interactions. Lukacs, N.W., Strieter, R.M., Elner, V., Evanoff, H.L., Burdick, M.D., Kunkel, S.L. Blood (1995) [Pubmed]
  41. Differential expression and release of CD54 induced by cytokines. Mickelson, J.K., Kukielka, G., Bravenec, J.S., Mainolfi, E., Rothlein, R., Hawkins, H.K., Kelly, J.H., Smith, C.W. Hepatology (1995) [Pubmed]
  42. Filamin B mediates ICAM-1-driven leukocyte transendothelial migration. Kanters, E., van Rijssel, J., Hensbergen, P.J., Hondius, D., Mul, F.P., Deelder, A.M., Sonnenberg, A., van Buul, J.D., Hordijk, P.L. J. Biol. Chem. (2008) [Pubmed]
  43. Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. Fawcett, J., Holness, C.L., Needham, L.A., Turley, H., Gatter, K.C., Mason, D.Y., Simmons, D.L. Nature (1992) [Pubmed]
  44. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis. McInnes, I.B., Leung, B.P., Sturrock, R.D., Field, M., Liew, F.Y. Nat. Med. (1997) [Pubmed]
  45. Activation and homologous desensitization of human endothelial cells by CD40 ligand, tumor necrosis factor, and interleukin 1. Karmann, K., Min, W., Fanslow, W.C., Pober, J.S. J. Exp. Med. (1996) [Pubmed]
  46. Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1. Ockenhouse, C.F., Tegoshi, T., Maeno, Y., Benjamin, C., Ho, M., Kan, K.E., Thway, Y., Win, K., Aikawa, M., Lobb, R.R. J. Exp. Med. (1992) [Pubmed]
  47. Cloning and expression of intercellular adhesion molecule 3 reveals strong homology to other immunoglobulin family counter-receptors for lymphocyte function-associated antigen 1. de Fougerolles, A.R., Klickstein, L.B., Springer, T.A. J. Exp. Med. (1993) [Pubmed]
  48. Endothelial cell cortactin coordinates intercellular adhesion molecule-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigration. Yang, L., Kowalski, J.R., Yacono, P., Bajmoczi, M., Shaw, S.K., Froio, R.M., Golan, D.E., Thomas, S.M., Luscinskas, F.W. J. Immunol. (2006) [Pubmed]
  49. Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells. Nagel, T., Resnick, N., Atkinson, W.J., Dewey, C.F., Gimbrone, M.A. J. Clin. Invest. (1994) [Pubmed]
  50. Association of intercellular adhesion molecule 1 with the multichain high-affinity interleukin 2 receptor. Burton, J., Goldman, C.K., Rao, P., Moos, M., Waldmann, T.A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
WikiGenes - Universities