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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Development of indole-3-propionic acid (OXIGON) for Alzheimer's disease.

The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer's disease. Indole-3-propionic acid ( IPA, OXIGON) is a potent anti-oxidant devoid of pro-oxidant activity. IPA has been demonstrated to be an inhibitor of beta-amyloid fibril formation and to be a potent neuroprotectant against a variety of oxidotoxins. This review will summarize the known properties of IPA and outline the rationale behind its selection as a potential disease-modifying therapy for Alzheimer's disease.[1]


  1. Development of indole-3-propionic acid (OXIGON) for Alzheimer's disease. Bendheim, P.E., Poeggeler, B., Neria, E., Ziv, V., Pappolla, M.A., Chain, D.G. J. Mol. Neurosci. (2002) [Pubmed]
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