Disease relevance of 5-22-03-00114 (Beilstein Handbook Reference)

• Susceptibility of Legionella pneumophila grown extracellularly and in human monocytes to indole-3-propionic acid [1].
• Effect of tryptophan analogs on derepression of the Escherichia coli tryptophan operon by indole-3-propionic acid [2].
• Amelioration of hepatic ischemia/reperfusion injury using indolepropionic acid [3].

Psychiatry related information on 5-22-03-00114 (Beilstein Handbook Reference)

• Based on previous reports of compounds that either bind to Abeta or are useful in treating Alzheimer's disease, melatonin, methysticin, 3-indolepropionic acid, and daunomycin were assayed and ranked in order of inhibition of Abeta aggregation [4].

High impact information on 5-22-03-00114 (Beilstein Handbook Reference)

• Instead, TaIAR3 has low specificity for the ester conjugates IAA-Glc and IAA-myoinositol and high specificity for the conjugates of indole-3-butyric acid (IBA-Ala and IBA-Gly) and indole-3-propionic-acid (IPA-Ala) so far tested [5].
• The origin of indoleacetic acid and indolepropionic acid in rat and human cerebrospinal fluid [6].
• Carcinogen-induced, free radical-mediated reduction in microsomal membrane fluidity: reversal by indole-3-propionic acid [7].
• Derepression of aroH expression by the L-tryptophan analogs, 3-beta-indoleacrylic acid and indole-3-propionic acid, is also documented [8].
• The kinetics of both HRPs with the substrates ABTS, ferrocyanide, ferulic acid, and indole-3-propionic acid were measured, as was binding of the inhibitor benzhydroxamic acid [9].

Biological context of 5-22-03-00114 (Beilstein Handbook Reference)

• The aim of the study was to compare the relative efficacies of melatonin, N-acetylserotonin (NAS), indole-3-propionic acid (IPA), and 5-hydroxy-indole-3-acetic acid (5HIAA) in altering basal and iron-induced lipid peroxidation in homogenates of hamster testes [10].

Anatomical context of 5-22-03-00114 (Beilstein Handbook Reference)

• Indole-3-propionic acid, a melatonin-related molecule, protects hepatic microsomal membranes from iron-induced oxidative damage: relevance to cancer reduction [11].

Associations of 5-22-03-00114 (Beilstein Handbook Reference) with other chemical compounds

• Protective effects of melatonin and indole-3-propionic acid against lipid peroxidation, caused by potassium bromate in the rat kidney [12].

Gene context of 5-22-03-00114 (Beilstein Handbook Reference)

• Retention times for DBI and IPA are 4.5 and 7.8 min, respectively, on the same C8 column with an acetonitrile-0.025 M acetate, pH 4.0 (22:78) mobile phase at a 2.0 ml/min flow-rate [13].
• Indole-3-propionic acid (IPA, OXIGON) is a potent anti-oxidant devoid of pro-oxidant activity [14].

Analytical, diagnostic and therapeutic context of 5-22-03-00114 (Beilstein Handbook Reference)

• A stepwise titration procedure was used to characterize the binding of indole-3-propionic acid to alpha-chymotrypsin [15].

References