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Chemical Compound Review

Oxigon     3-(1H-indol-3-yl)propanoic acid

Synonyms: OX-1, PubChem16937, CHEMBL207225, SureCN195405, NSC-3252, ...
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Disease relevance of 5-22-03-00114 (Beilstein Handbook Reference)


Psychiatry related information on 5-22-03-00114 (Beilstein Handbook Reference)


High impact information on 5-22-03-00114 (Beilstein Handbook Reference)


Biological context of 5-22-03-00114 (Beilstein Handbook Reference)


Anatomical context of 5-22-03-00114 (Beilstein Handbook Reference)


Associations of 5-22-03-00114 (Beilstein Handbook Reference) with other chemical compounds


Gene context of 5-22-03-00114 (Beilstein Handbook Reference)

  • Retention times for DBI and IPA are 4.5 and 7.8 min, respectively, on the same C8 column with an acetonitrile-0.025 M acetate, pH 4.0 (22:78) mobile phase at a 2.0 ml/min flow-rate [13].
  • Indole-3-propionic acid (IPA, OXIGON) is a potent anti-oxidant devoid of pro-oxidant activity [14].

Analytical, diagnostic and therapeutic context of 5-22-03-00114 (Beilstein Handbook Reference)


  1. Susceptibility of Legionella pneumophila grown extracellularly and in human monocytes to indole-3-propionic acid. Mandelbaum-Shavit, F., Barak, V., Saheb-Tamimi, K., Grossowicz, N. Antimicrob. Agents Chemother. (1991) [Pubmed]
  2. Effect of tryptophan analogs on derepression of the Escherichia coli tryptophan operon by indole-3-propionic acid. Pauley, R.J., Fredricks, W.W., Smith, O.H. J. Bacteriol. (1978) [Pubmed]
  3. Amelioration of hepatic ischemia/reperfusion injury using indolepropionic acid. Lefler, S.R., St Peter, S.D., Rodriguez-Davalos, M.I., Perumean, J.C., Spence, N.A., Moss, A.A., Mulligan, D.C. Transplant. Proc. (2002) [Pubmed]
  4. Mass spectrometry-based screening for inhibitors of beta-amyloid protein aggregation. Cheng, X., van Breemen, R.B. Anal. Chem. (2005) [Pubmed]
  5. A novel auxin conjugate hydrolase from wheat with substrate specificity for longer side-chain auxin amide conjugates. Campanella, J.J., Olajide, A.F., Magnus, V., Ludwig-Müller, J. Plant Physiol. (2004) [Pubmed]
  6. The origin of indoleacetic acid and indolepropionic acid in rat and human cerebrospinal fluid. Young, S.N., Anderson, G.M., Gauthier, S., Purdy, W.C. J. Neurochem. (1980) [Pubmed]
  7. Carcinogen-induced, free radical-mediated reduction in microsomal membrane fluidity: reversal by indole-3-propionic acid. Karbownik, M., Garcia, J.J., Lewiński, A., Reiter, R.J. J. Bioenerg. Biomembr. (2001) [Pubmed]
  8. Regulation of the aroH operon of Escherichia coli by the tryptophan repressor. Grove, C.L., Gunsalus, R.P. J. Bacteriol. (1987) [Pubmed]
  9. Effects of phthalic anhydride modification on horseradish peroxidase stability and activity. O'Brien, A.M., Smith, A.T., O'Fágáin, C. Biotechnol. Bioeng. (2003) [Pubmed]
  10. Relative efficacies of indole antioxidants in reducing autoxidation and iron-induced lipid peroxidation in hamster testes. Karbownik, M., Gitto, E., Lewiñski, A., Reiter, R.J. J. Cell. Biochem. (2001) [Pubmed]
  11. Indole-3-propionic acid, a melatonin-related molecule, protects hepatic microsomal membranes from iron-induced oxidative damage: relevance to cancer reduction. Karbownik, M., Reiter, R.J., Garcia, J.J., Cabrera, J., Burkhardt, S., Osuna, C., Lewiński, A. J. Cell. Biochem. (2001) [Pubmed]
  12. Protective effects of melatonin and indole-3-propionic acid against lipid peroxidation, caused by potassium bromate in the rat kidney. Karbownik, M., Stasiak, M., Zygmunt, A., Zasada, K., Lewi??ski, A. Cell Biochem. Funct. (2006) [Pubmed]
  13. High-performance liquid chromatographic method for the determination of indomethacin and its two primary metabolites in urine. Smith, P.C., Benet, L.Z. J. Chromatogr. (1984) [Pubmed]
  14. Development of indole-3-propionic acid (OXIGON) for Alzheimer's disease. Bendheim, P.E., Poeggeler, B., Neria, E., Ziv, V., Pappolla, M.A., Chain, D.G. J. Mol. Neurosci. (2002) [Pubmed]
  15. Simultaneous determination of delta G, delta H and delta S by an automatic microcalorimetric titration technique. Application to protein ligand binding. Chen, A., Wadsö, I. J. Biochem. Biophys. Methods (1982) [Pubmed]
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