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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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An efficient synthesis of novel carbocyclic nucleosides with use of ring-closing metathesis from D-lactose.

This paper describes an efficient synthetic route for various types of novel carbocyclic nucleosides. The required stereochemistry of the targeted nucleosides was successfully obtained with use of Grubbs cyclization and Trost allylic alkylation from the carbohydrate chiral template "D-lactose".[1]

References

  1. An efficient synthesis of novel carbocyclic nucleosides with use of ring-closing metathesis from D-lactose. Hong, J.H., Shim, M.J., Ro, B.O., Ko, O.H. J. Org. Chem. (2002) [Pubmed]
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