- A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol. Mylari, B.L., Oates, P.J., Zembrowski, W.J., Beebe, D.A., Conn, E.L., Coutcher, J.B., O'Gorman, M.T., Linhares, M.C., Withbroe, G.J. J. Med. Chem. (2002)