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MeSH Review

Sciatic Nerve

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Disease relevance of Sciatic Nerve


Psychiatry related information on Sciatic Nerve


High impact information on Sciatic Nerve

  • Using recombinant fragments of LN-alpha2 (rLN-alpha2), the M. leprae-binding site was localized to the G domain. rLN-alpha2G mediated M. leprae binding to cell lines and to sciatic nerves of dystrophic dy/dy mice lacking LN-alpha2, but expressing laminin receptors [11].
  • In control sciatic nerves with grafted Trembler nerve segments, these changes were spatially restricted: they were confined to axon segments without normal myelination [12].
  • Daily administration of progesterone elevated the steady-state levels of Pmp22 and Mpz mRNA in the sciatic nerve, resulting in enhanced Schwann cell pathology and a more progressive clinical neuropathy [13].
  • Although CNTF is abundant in adult sciatic nerve, the mature protein lacks a signal sequence and is not secreted; therefore, it has been proposed to act as a lesion factor [14].
  • Here we report that after lesion of the rat sciatic nerve there is a large transient increase in the amount of GDN messenger RNA and of released GDN [15].

Chemical compound and disease context of Sciatic Nerve


Biological context of Sciatic Nerve


Anatomical context of Sciatic Nerve


Associations of Sciatic Nerve with chemical compounds


Gene context of Sciatic Nerve


Analytical, diagnostic and therapeutic context of Sciatic Nerve


  1. Parvalbumin is reduced in the peripheral nerves of diabetic rats. Endo, T., Onaya, T. J. Clin. Invest. (1986) [Pubmed]
  2. Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves. Okuda, T., Higashi, Y., Kokame, K., Tanaka, C., Kondoh, H., Miyata, T. Mol. Cell. Biol. (2004) [Pubmed]
  3. Activation of ErbB2 during wallerian degeneration of sciatic nerve. Kwon, Y.K., Bhattacharyya, A., Alberta, J.A., Giannobile, W.V., Cheon, K., Stiles, C.D., Pomeroy, S.L. J. Neurosci. (1997) [Pubmed]
  4. In vivo demyelinating activity of sera from patients with Guillain-Barré syndrome. Saida, T., Saida, K., Lisak, R.P., Brown, M.J., Silberberg, D.H., Asbury, A.K. Ann. Neurol. (1982) [Pubmed]
  5. Peripheral nerve pathological findings in familial amyloid polyneuropathy: a correlative study of proximal sciatic nerve and sural nerve lesions. Hanyu, N., Ikeda, S., Nakadai, A., Yanagisawa, N., Powell, H.C. Ann. Neurol. (1989) [Pubmed]
  6. Update on cellular transplantation into the CNS as a novel therapy for chronic pain. Czech, K.A., Sagen, J. Prog. Neurobiol. (1995) [Pubmed]
  7. Neurophysiologic actions and neurological consequences of veratridine on the rat sciatic nerve. Vladimirov, M., Thalhammer, J.G., Hunt, N., Feldman, H.S., Strichartz, G. Anesthesiology (1997) [Pubmed]
  8. Motor nerve blockade potency and toxicity of non-racemic bupivacaine in rats. Trachez, M.M., Zapata-Sudo, G., Moreira, O.R., Chedid, N.G., Russo, V.F., Russo, E.M., Sudo, R.T. Acta anaesthesiologica Scandinavica. (2005) [Pubmed]
  9. Experimental depressive-pain syndrome in rats with initial various anxiety-phobic levels: a behavioral study. Krupina, N.A., Orlova, I.N., Khlebnikova, N.N., Grafova, V.N., Smirnova, V.S., Kukushkin, M.L., Kryzhanovskii, G.N., Pankova, N.B., Rodina, V.I. Bull. Exp. Biol. Med. (2002) [Pubmed]
  10. Reduction of cerebrospinal fluid glutamic acid in Huntington's chorea and in schizophrenic patients. Kim, J.S., Kornhuber, H.H., Holzmüller, B., Schmid-Burgk, W., Mergner, T., Krzepinski, G. Archiv für Psychiatrie und Nervenkrankheiten. (1980) [Pubmed]
  11. Neural targeting of Mycobacterium leprae mediated by the G domain of the laminin-alpha2 chain. Rambukkana, A., Salzer, J.L., Yurchenco, P.D., Tuomanen, E.I. Cell (1997) [Pubmed]
  12. Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells. de Waegh, S.M., Lee, V.M., Brady, S.T. Cell (1992) [Pubmed]
  13. Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A). Sereda, M.W., Meyer zu Hörste, G., Suter, U., Uzma, N., Nave, K.A. Nat. Med. (2003) [Pubmed]
  14. Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury. Curtis, R., Adryan, K.M., Zhu, Y., Harkness, P.J., Lindsay, R.M., DiStefano, P.S. Nature (1993) [Pubmed]
  15. Induction of glia-derived nexin after lesion of a peripheral nerve. Meier, R., Spreyer, P., Ortmann, R., Harel, A., Monard, D. Nature (1989) [Pubmed]
  16. Red blood cell sorbitol as an indicator of polyol pathway activity. Inhibition by sorbinil in insulin-dependent diabetic subjects. Malone, J.I., Leavengood, H., Peterson, M.J., O'Brien, M.M., Page, M.G., Aldinger, C.E. Diabetes (1984) [Pubmed]
  17. Increased susceptibility to ischemic damage in streptozocin-diabetic nerve. Nukada, H. Diabetes (1986) [Pubmed]
  18. Effects of acute, subacute, and chronic diabetes on carbohydrate and energy metabolism in rat sciatic nerve. Relation to mechanisms of peripheral neuropathy. Thurston, J.H., McDougal, D.B., Hauhart, R.E., Schulz, D.W. Diabetes (1995) [Pubmed]
  19. Diabetes mellitus prevents capsaicin from inducing hyperaemia in the rat sciatic nerve. Zochodne, D.W., Ho, L.T. Diabetologia (1993) [Pubmed]
  20. Effect of sorbitol dehydrogenase inhibition on experimental diabetic autonomic neuropathy. Schmidt, R.E., Dorsey, D.A., Beaudet, L.N., Plurad, S.B., Williamson, J.R., Ido, Y. J. Neuropathol. Exp. Neurol. (1998) [Pubmed]
  21. Axo-glial dysjunction. A novel structural lesion that accounts for poorly reversible slowing of nerve conduction in the spontaneously diabetic bio-breeding rat. Sima, A.A., Lattimer, S.A., Yagihashi, S., Greene, D.A. J. Clin. Invest. (1986) [Pubmed]
  22. Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and myelin-associated glycoprotein) in regenerating adult mouse sciatic nerve. Martini, R., Schachner, M. J. Cell Biol. (1988) [Pubmed]
  23. Regeneration-associated high level expression of apolipoprotein D mRNA in endoneurial fibroblasts of peripheral nerve. Spreyer, P., Schaal, H., Kuhn, G., Rothe, T., Unterbeck, A., Olek, K., Müller, H.W. EMBO J. (1990) [Pubmed]
  24. Relationship of insulin-like growth factor II gene expression in muscle to synaptogenesis. Ishii, D.N. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  25. Homozygous defects in LMNA, encoding lamin A/C nuclear-envelope proteins, cause autosomal recessive axonal neuropathy in human (Charcot-Marie-Tooth disorder type 2) and mouse. De Sandre-Giovannoli, A., Chaouch, M., Kozlov, S., Vallat, J.M., Tazir, M., Kassouri, N., Szepetowski, P., Hammadouche, T., Vandenberghe, A., Stewart, C.L., Grid, D., Lévy, N. Am. J. Hum. Genet. (2002) [Pubmed]
  26. Adipsin: a circulating serine protease homolog secreted by adipose tissue and sciatic nerve. Cook, K.S., Min, H.Y., Johnson, D., Chaplinsky, R.J., Flier, J.S., Hunt, C.R., Spiegelman, B.M. Science (1987) [Pubmed]
  27. Sodium- and energy-dependent uptake of myo-inositol by rabbit peripheral nerve. Competitive inhibition by glucose and lack of an insulin effect. Greene, D.A., Lattimer, S.A. J. Clin. Invest. (1982) [Pubmed]
  28. Persephin, a novel neurotrophic factor related to GDNF and neurturin. Milbrandt, J., de Sauvage, F.J., Fahrner, T.J., Baloh, R.H., Leitner, M.L., Tansey, M.G., Lampe, P.A., Heuckeroth, R.O., Kotzbauer, P.T., Simburger, K.S., Golden, J.P., Davies, J.A., Vejsada, R., Kato, A.C., Hynes, M., Sherman, D., Nishimura, M., Wang, L.C., Vandlen, R., Moffat, B., Klein, R.D., Poulsen, K., Gray, C., Garces, A., Johnson, E.M. Neuron (1998) [Pubmed]
  29. Distinct ankyrin isoforms at neuron cell bodies and nodes of Ranvier resolved using erythrocyte ankyrin-deficient mice. Kordeli, E., Bennett, V. J. Cell Biol. (1991) [Pubmed]
  30. Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. Funakoshi, H., Frisén, J., Barbany, G., Timmusk, T., Zachrisson, O., Verge, V.M., Persson, H. J. Cell Biol. (1993) [Pubmed]
  31. Impaired rat sciatic nerve sodium-potassium adenosine triphosphatase in acute streptozocin diabetes and its correction by dietary myo-inositol supplementation. Greene, D.A., Lattimer, S.A. J. Clin. Invest. (1983) [Pubmed]
  32. A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. Boyles, J.K., Zoellner, C.D., Anderson, L.J., Kosik, L.M., Pitas, R.E., Weisgraber, K.H., Hui, D.Y., Mahley, R.W., Gebicke-Haerter, P.J., Ignatius, M.J. J. Clin. Invest. (1989) [Pubmed]
  33. Neurovascular dysfunction in diabetic rats. Potential contribution of autoxidation and free radicals examined using transition metal chelating agents. Cameron, N.E., Cotter, M.A. J. Clin. Invest. (1995) [Pubmed]
  34. Synthesis of the transferrin receptor by cultures of embryonic chicken spinal neurons. Markelonis, G.J., Oh, T.H., Park, L.P., Cha, C.Y., Sofia, C.A., Kim, J.W., Azari, P. J. Cell Biol. (1985) [Pubmed]
  35. Incorporation of newly formed lecithin into peripheral nerve myelin. Gould, R.M., Dawson, R.M. J. Cell Biol. (1976) [Pubmed]
  36. Pax3: a paired domain gene as a regulator in PNS myelination. Kioussi, C., Gross, M.K., Gruss, P. Neuron (1995) [Pubmed]
  37. Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway. Yamauchi, J., Chan, J.R., Shooter, E.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  38. Lesion-induced increase in nerve growth factor mRNA is mediated by c-fos. Hengerer, B., Lindholm, D., Heumann, R., Rüther, U., Wagner, E.F., Thoenen, H. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  39. Association of calnexin with mutant peripheral myelin protein-22 ex vivo: a basis for "gain-of-function" ER diseases. Dickson, K.M., Bergeron, J.J., Shames, I., Colby, J., Nguyen, D.T., Chevet, E., Thomas, D.Y., Snipes, G.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  40. Regulation of neural cell adhesion molecule expression on cultured mouse Schwann cells by nerve growth factor. Seilheimer, B., Schachner, M. EMBO J. (1987) [Pubmed]
  41. Stimulation of neurite outgrowth using an electrically conducting polymer. Schmidt, C.E., Shastri, V.R., Vacanti, J.P., Langer, R. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  42. Mutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like disease. Uhlenberg, B., Schuelke, M., Rüschendorf, F., Ruf, N., Kaindl, A.M., Henneke, M., Thiele, H., Stoltenburg-Didinger, G., Aksu, F., Topaloğlu, H., Nürnberg, P., Hübner, C., Weschke, B., Gärtner, J. Am. J. Hum. Genet. (2004) [Pubmed]
  43. Demonstration of the retrograde transport of nerve growth factor receptor in the peripheral and central nervous system. Johnson, E.M., Taniuchi, M., Clark, H.B., Springer, J.E., Koh, S., Tayrien, M.W., Loy, R. J. Neurosci. (1987) [Pubmed]
  44. Inflammation near the nerve cell body enhances axonal regeneration. Lu, X., Richardson, P.M. J. Neurosci. (1991) [Pubmed]
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