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Yamakuni, T. et al.

Yamakuni, Yamamoto, Ishida, Yamamoto, Song, Adachi, Hiwatashi, Ohizumi,

V-1, a catecholamine biosynthesis regulatory protein, positively controls catecholamine secretion in PC12D cells.

Stably transfected PC12D cell lines overexpressing a catecholamine biosynthesis regulatory protein, V-1, were used to examine the functional role of V-1 in catecholamine secretion. High K(+)-induced dopamine secretion in V-1 overexpressing clones was shown to be markedly potentiated compared with control clones carried with a vector alone. As assayed intracellular calcium concentration ([Ca(2+)](i)) using fura-PE3, V-1 overexpression was observed to enhance high K(+)-elicited [Ca(2+)](i) elevation. Electron microscopic analysis revealed an increase in dense-cored vesicle formation by V-1 overexpression. These results suggest that the enhancement of high K(+)-induced dopamine secretion by V-1 overexpression results from the potentiation of high K(+)-induced [Ca(2+)](i) elevation and the increase in the number of dense-cored vesicles.[1]

References

V-1, a catecholamine biosynthesis regulatory protein, positively controls catecholamine secretion in PC12D cells. Yamakuni, T., Yamamoto, T., Ishida, Y., Yamamoto, H., Song, S.Y., Adachi, E., Hiwatashi, Y., Ohizumi, Y. FEBS Lett. (2002) [Pubmed]

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