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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

PCOLCE deletion and expression analyses in uterine leiomyomata.

Uterine leiomyomata (UL) are benign tumors affecting many women of reproductive age. Cytogenetic studies have indicated that a significant percentage of leiomyomata have chromosomal rearrangements, including those involving the long arm of chromosome 7. Several candidate genes that map to chromosome 7 have been studied for possible roles in the pathogenesis of these tumors. PCOLCE, a gene whose product is involved in the cleavage of type I procollagen C-propeptide, has been mapped to the critical interval on chromosome 7, band q22. Here we evaluate by reverse-transcriptase polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization the expression and deletion status of PCOLCE in a series of karyotyped uterine leiomyomata.[1]


  1. PCOLCE deletion and expression analyses in uterine leiomyomata. Ligon, A.H., Scott, I.C., Takahara, K., Greenspan, D.S., Morton, C.C. Cancer Genet. Cytogenet. (2002) [Pubmed]
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