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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Methaqualone: tolerance and physical dependence in mice.

Tolerance and physical dependence was produced in C57Bl/6 male mice that had been exposed, for 36 days, to methaqualone in food pellets via an automated system. Tolerance was revealed in the reduction of sleep-times following intraperitoneal injection of methaqualone. Physical dependence was manifested as an alteration in neural sensitivity to flurothyl-induced convulsions.[1]


  1. Methaqualone: tolerance and physical dependence in mice. Alpern, H.P., Greer, C.A., Stripling, J.S., Collins, A.C., Olson, R.K. Psychopharmacologia. (1975) [Pubmed]
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