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Chemical Compound Review

Quaalude     2-methyl-3-(2- methylphenyl)quinazolin-4-one

Synonyms: Cateudyl, Dormigoa, Dormogen, Dormutil, Dorsedin, ...
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Disease relevance of Ortonal


Psychiatry related information on Ortonal


High impact information on Ortonal


Chemical compound and disease context of Ortonal


Biological context of Ortonal

  • The major biotransformation of methaqualone under therapeutic conditions occurred through benzylic and para-hydroxylation of the o-tolyl moiety [18].
  • 2 The apparent first order rate constants for the formation of five C-monohydroxy metabolites of methaqualone on day 15 of the menstrual cycle were approximately double that on day 1 [19].
  • Correlation between dissolution rate and bioavailability was shown in freshly prepared methaqualone tablet formulations [20].
  • Hydroxylation of the tolyl moiety of methaqualone probably occurs by way of an epoxide intermediate [21].
  • The major monohydroxyl metabolites of methaqualone detected in human urine after enzymic hydrolysis were I, II, 2-methyl-3-(3'-hydroxy-2'-methylphenyl)-4(3H)-quinazolinone (III), and 2-methyl-3-(4'-hydroxy-2'-methylphenyl)-4(3H)-quinazolinone (IV) [21].

Anatomical context of Ortonal


Associations of Ortonal with other chemical compounds


Gene context of Ortonal


Analytical, diagnostic and therapeutic context of Ortonal


  1. Effect of T4 count and cofactors on the incidence of AIDS in homosexual men infected with human immunodeficiency virus. Goedert, J.J., Biggar, R.J., Melbye, M., Mann, D.L., Wilson, S., Gail, M.H., Grossman, R.J., DiGioia, R.A., Sanchez, W.C., Weiss, S.H. JAMA (1987) [Pubmed]
  2. Effects of methaqualone on blood platelet function. Mills, D.G. Clin. Pharmacol. Ther. (1978) [Pubmed]
  3. Methaqualone withdrawal syndrome with photoparoxysmal responses and high-amplitude visual evoked potentials. Faught, E. Neurology (1986) [Pubmed]
  4. The effects of methaqualone on pituitary-adrenocortical activity in mice. Meyer, J.S., Boggan, W.O. Psychopharmacology (Berl.) (1977) [Pubmed]
  5. Induction of hepatic enzymes by methaqualone and effect on warfarin-induced hypoprothrombinemia. Mathur, P.P., Smyth, R.D., Herczeg, T., Reavey-Cantwell, N.H. J. Pharmacol. Exp. Ther. (1976) [Pubmed]
  6. Dose effects of methaqualone on stimulus encoding in a memory scanning task. Smith, L.T., Williams, H.L., Rundell, O.H. Psychopharmacology (Berl.) (1988) [Pubmed]
  7. Methaqualone ingestion: evaluation of present status. Bailey, D.N. Journal of analytical toxicology. (1981) [Pubmed]
  8. Effect of cannabis use on oral candidal carriage. Darling, M.R., Arendorf, T.M., Coldrey, N.A. J. Oral Pathol. Med. (1990) [Pubmed]
  9. Incidence of methaqualone in driving-under-the-influence (DUI) cases in the state of Georgia. McCurdy, H.H., Solomons, E.T., Holbrook, J.M. Journal of analytical toxicology. (1981) [Pubmed]
  10. Effects of methaqualone on social behavior in monkeys (Macaca mulatta). Claus, G., Kling, A., Bolander, K. Brain Behav. Evol. (1980) [Pubmed]
  11. Enantiomeric analysis of the five major monohydroxylated metabolites of methaqualone in human urine by chiral capillary electrophoresis. Prost, F., Thormann, W. Electrophoresis (2001) [Pubmed]
  12. Inhibition of apolipoprotein B and triglyceride secretion in human hepatoma cells (HepG2). Haghpassand, M., Wilder, D., Moberly, J.B. J. Lipid Res. (1996) [Pubmed]
  13. Behavioural sequelae of methaqualone in man and in the monkey (Macaca mulatta). Borland, R.G., Nicholson, A.N., Wright, C.M. British journal of clinical pharmacology. (1975) [Pubmed]
  14. Pigmented lesions of the tongue in heroin addicts--fixed drug eruption. Westerhof, W., Wolters, E.C., Brookbakker, J.T., Boelen, R.E., Schipper, M.E. Br. J. Dermatol. (1983) [Pubmed]
  15. Interactions between methaqualone and ethanol in rats and mice during acute and chronic states. Ho, C.C., Ho, A.K. Clin. Exp. Pharmacol. Physiol. (1978) [Pubmed]
  16. Effects of d-amphetamine, methaqualone, and phencyclidine on the reaction time of pigeons. Kaczor, T., Blakely, E., Poling, A. Pharmacol. Biochem. Behav. (1993) [Pubmed]
  17. Shift of the high-performance liquid chromatographic retention times of metabolites in relation to the original drug on an RP8 column with acidic mobile phase. Herre, S., Pragst, F. J. Chromatogr. B Biomed. Sci. Appl. (1997) [Pubmed]
  18. Methaqualone metabolites in human urine after therapeutic doses. Kazyak, L., Kelley, J.A., Cella, J.A., Droege, R.E., Hilpert, L.R., Permisohn, R.C. Clin. Chem. (1977) [Pubmed]
  19. The influence of the menstrual cycle on the metabolism and clearance of methaqualone. Wilson, K., Oram, M., Horth, C.E., Burnett, D. British journal of clinical pharmacology. (1982) [Pubmed]
  20. Correlation between dissolution characteristics and absorption of methaqualone from solid dosage forms. Chemburkar, P.B., Smyth, R.D., Buehler, J.D., Shah, P.B., Joslin, R.S., Polk, A., Reavey-Cantwell, N.H. Journal of pharmaceutical sciences. (1976) [Pubmed]
  21. Metabolism of methaqualone by the epoxide-diol pathway in man and the rat. Stillwell, W.G., Gregory, P.A., Horning, M.G. Drug Metab. Dispos. (1975) [Pubmed]
  22. Synthesis and central nervous system activity of quinazolones related to 2-methyl-3-(o-tolyl)-4(3H)-quinazolone (methaqualone). Ager, I.R., Harrison, D.R., Kennewell, P.D., Taylor, J.B. J. Med. Chem. (1977) [Pubmed]
  23. Precolumns of amberlite XAD-2 for direct injection liquid chromatographic determination of methaqualone in blood plasma. Hux, R.A., Mohammed, H.Y., Cantwell, F.F. Anal. Chem. (1982) [Pubmed]
  24. Methaqualone in human serum and cerebrospinal fluid after oral intake. Christensen, J.M., Holfort, S. J. Pharm. Pharmacol. (1975) [Pubmed]
  25. Induction of hepatic UDP-glucuronyltransferase by oral methaqualone consumption. Kaur, S., Ali, B. Res. Commun. Chem. Pathol. Pharmacol. (1982) [Pubmed]
  26. Methaqualone metabolism by rat liver microsomes. Manowitz, P., Shull, C.M. Res. Commun. Chem. Pathol. Pharmacol. (1976) [Pubmed]
  27. Analysis of illicit drugs in human urine by micellar electrokinetic capillary chromatography with on-column fast scanning polychrome absorption detection. Wernly, P., Thormann, W. Anal. Chem. (1991) [Pubmed]
  28. Benzodiazepine receptor binding: the interactions of some non-benzodiazepine drugs with specific [3H] diazepam binding to rat brain synaptosomal membranes. Müller, W.E., Schläfer, U., Wollert, U. Naunyn Schmiedebergs Arch. Pharmacol. (1978) [Pubmed]
  29. The removal of hypnotic drugs from human serum. A comparative investigation of the adsorptive properties of native and agarose-encapsulated resins and charcoal. Harstick, K., Holloway, C.J., Brunner, G., Külpmann, W.R., Petry, K. The International journal of artificial organs. (1979) [Pubmed]
  30. Effects of dixyrazine and methaqualone on the sleep pattern in normal man. Risberg, A.M., Risberg, J., Elmqvist, D., Ingvar, D.H. Eur. J. Clin. Pharmacol. (1975) [Pubmed]
  31. The effects of methaqualone on the seizure susceptibility of mice. Boggan, W.O., Meyer, J.S., Steinberg, R.M., Worthington, C. Psychopharmacology (Berl.) (1977) [Pubmed]
  32. Electrospray-assisted laser desorption/ionization mass spectrometry for direct ambient analysis of solids. Shiea, J., Huang, M.Z., Hsu, H.J., Lee, C.Y., Yuan, C.H., Beech, I., Sunner, J. Rapid Commun. Mass Spectrom. (2005) [Pubmed]
  33. Methaqualone-diphenhydramine interaction study in humans. Hindmarsh, K.W., Wallace, S.M., Schneider, C.B., Korchinski, E.D. Journal of pharmaceutical sciences. (1983) [Pubmed]
  34. Radioimmunoassay of methaqualone in human urine compared with chromatographic methods. Mulé, S.J., Kogan, M., Jukofsky, D. Clin. Chem. (1978) [Pubmed]
  35. Thin-layer chromatographic detection and identification of methaqualone metabolites in urine. Sleeman, H.K., Cella, J.A., Harvey, J.L., Beach, D.J. Clin. Chem. (1975) [Pubmed]
  36. Assessment of the stereoselective metabolism of methaqualone in man by capillary electrophoresis. Prost, F., Thormann, W. Electrophoresis (2003) [Pubmed]
  37. Methaqualone: tolerance and physical dependence in mice. Alpern, H.P., Greer, C.A., Stripling, J.S., Collins, A.C., Olson, R.K. Psychopharmacologia. (1975) [Pubmed]
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