Disease relevance of Ortonal

• Several of 40 potential cofactors defined ex post facto, including receptive fellatio, enemas, methaqualone use, and high levels of antibody to hepatitis B surface antigen, appeared to be associated with Kaposi's sarcoma but not with Pneumocystis pneumonia [1].
• These results suggest that a drug-induced defect of blood platelet function may play a role in the bleeding associated with methaqualone toxicity [2].
• In the patient studied, methaqualone withdrawal was manifested by myoclonic and tonic-clonic seizures, an EEG photoparoxysmal response (PPR), and a high-amplitude visual evoked potential (VEP) to pattern-reversal stimuli [3].
• Acute studies showed that this effect is largely independent of methaqualone-induced hypothermia but can be blocked by pretreatment with dexamethasone, thus demonstrating that the adrenal cortex is not being directly stimulated [4].
• Induction of hepatic enzymes by methaqualone and effect on warfarin-induced hypoprothrombinemia [5].

Psychiatry related information on Ortonal

• Mean reaction times were increased significantly by the methaqualone at both doses, but the effects of the two doses did not differ from one another [6].
• He was admitted to the emergency room with a depressed level of consciousness and a serum methaqualone concentration of 5 +/- 3 mg/L (mean +/- SD) [7].
• In this investigation, the effect of cannabis smoking combined with methaqualone and tobacco on candidal prevalence, density and candidosis was examined in 55 users [8].
• The range of blood methaqualone levels, which appear to cause significant motor skill impairment, are discussed for each category [9].
• Effects of methaqualone on social behavior in monkeys (Macaca mulatta) [10].

High impact information on Ortonal

• Methaqualone withdrawal syndrome with photoparoxysmal responses and high-amplitude visual evoked potentials [3].
• To study the mechanism whereby toxic doses of methaqualone cause a bleeding tendency in humans, the effects of methaqualone, diphenhydramine, and the combination of methaqualone plus diphenhydramine on blood platelet function were investigated [2].
• Effects of methaqualone on blood platelet function [2].
• Methaqualone (MQ; 2-methyl-3-o-tolylquinazolin-4(3H)-one) is a hypnotic and anticonvulsive drug in which the rotation about the nitrogen-to-aryl bond between the planar 2-methyl-quinazolin-4(3H)-one structure and the o-tolyl moiety is sterically hindered at body temperature [11].
• CP-10447, a derivative of the hypnotic drug methaqualone (Quaalude), inhibited apoB secretion from HepG2 cells with an IC50 of approximately 5 microM [12].

Chemical compound and disease context of Ortonal

• 1 Residual effects in man of methaqualone hydrochloride (400 mg) were studied by adaptive tracking and by reaction time [13].
• We describe a case in which it was due to a fixed drug eruption following the inhalation of heroin pyrolysate and methaqualone vapours [14].
• Potentiation of ethanol toxicity by methaqualone may be of clinical importance in view of the narrow range of safety margin of ethanol [15].
• Effects of d-amphetamine, methaqualone, and phencyclidine on the reaction time of pigeons [16].
• The practical use of the T(M) values as a support to distinguish between different metabolites in the HPLC-DAD analysis of intoxications is demonstrated with cases of poisoning with diphenhydramine, propafenone and methaqualone [17].

Biological context of Ortonal

• The major biotransformation of methaqualone under therapeutic conditions occurred through benzylic and para-hydroxylation of the o-tolyl moiety [18].
• 2 The apparent first order rate constants for the formation of five C-monohydroxy metabolites of methaqualone on day 15 of the menstrual cycle were approximately double that on day 1 [19].
• Correlation between dissolution rate and bioavailability was shown in freshly prepared methaqualone tablet formulations [20].
• Hydroxylation of the tolyl moiety of methaqualone probably occurs by way of an epoxide intermediate [21].
• The major monohydroxyl metabolites of methaqualone detected in human urine after enzymic hydrolysis were I, II, 2-methyl-3-(3'-hydroxy-2'-methylphenyl)-4(3H)-quinazolinone (III), and 2-methyl-3-(4'-hydroxy-2'-methylphenyl)-4(3H)-quinazolinone (IV) [21].

Anatomical context of Ortonal

• Synthesis and central nervous system activity of quinazolones related to 2-methyl-3-(o-tolyl)-4(3H)-quinazolone (methaqualone) [22].
• Precolumns of amberlite XAD-2 for direct injection liquid chromatographic determination of methaqualone in blood plasma [23].
• Methaqualone in human serum and cerebrospinal fluid after oral intake [24].
• Interestingly, the magnitude of UDP-glucuronyltransferase stimulation by methaqualone, when assessed in crude liver homogenate, was comparable to that obtained with isolated microsomes [25].
• Methaqualone metabolism by rat liver microsomes [26].

Associations of Ortonal with other chemical compounds

• Using micellar electrokinetic capillary chromatography (MECC) with a borate/phosphate buffer containing 75 mM SDS (pH 9.1), common drugs of abuse and/or their metabolites, including opioids, benzoylecgonine, amphetamines, and methaqualone, can easily be analyzed [27].
• The most potent non-benzodiazepine drug for inhibiting specific [3H] diazepam binding was methaqualone (IC50 value of 150 micrometer) [28].
• Co-administration of ethanol using 6.0, 7.0 and 8.0 g/kg also reduced the LD50 of methaqualone by 19%, 24% and 40%, respectively [15].
• The adsorptive capacities of some ion-exchange resins and activated charcoal towards the hypnotic drugs, phenobarbital, glutethimide, carbromal, and methaqualone, have been investigated [29].
• Whole night EEG and polygraphic recordings were made in ten young, healthy, male volunteers after dixyrazine (12.5 mg, 25 mg, 50 mg), methaqualone (250 mg) and Isonox (methaqualone 250 mg + etodroxizine 50 mg) [30].

Gene context of Ortonal

• The effects of methaqualone on the seizure susceptibility of mice [31].
• Bovine cytochrome c and an illicit drug containing methaqualone were chosen in this study to demonstrate the applicability of ELDI to the analysis of proteins and synthetic organic compounds [32].
• The area under the blood level-time curve, peak plasma level, and elimination half-life for methaqualone were not significantly different (three-way ANOVA, p greater than 0.05) when methaqualone was administered alone, in combination with a diphenhydramine elixir or as a commercial product (capsule) containing both methaqualone and diphenhydramine [33].
• Methaqualone also caused moderate depression of REM-sleep during the first night of treatment, and this effect, too, disappeared during prolonged administration [30].
• 5. Chronic administration with ethanol decreased the toxicity due to methaqualone [15].

Analytical, diagnostic and therapeutic context of Ortonal

• Radioimmunoassay of methaqualone in human urine compared with chromatographic methods [34].
• Urine, collected for up to 72 hours after the last dose, was analyzed for methaqualone and its principal metabolites by high-resolution capillary-column gas chromatography [18].
• A procedure for detecting methaqualone and identifying methaqualone metabolites in urine by thin-layer chromatography is described and evaluated [35].
• Assessment of the stereoselective metabolism of methaqualone in man by capillary electrophoresis [36].
• Tolerance was revealed in the reduction of sleep-times following intraperitoneal injection of methaqualone [37].

References