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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Protein-cleaving catalyst selective for protein substrate.

A protein-cleaving catalyst specific for a disease-related protein can be used as a catalytic drug. As the first protein-cleaving catalyst selective for a protein substrate, a catalyst for myoglobin was designed by attaching Cu(II) or Co(III) complex of cyclen to a binding site searched by a combinatorial method using peptide nucleic acid monomers as building units. [reaction: see text][1]


  1. Protein-cleaving catalyst selective for protein substrate. Jeon, J.W., Son, S.J., Yoo, C.E., Hong, I.S., Song, J.B., Suh, J. Org. Lett. (2002) [Pubmed]
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