Comparative mapping of CDY and DAZ in higher primates.
The human male specific expressed gene families CDY and DAZ are known to be repetitively clustered in the Y-specific region of the human Y chromosome. Comparative FISH-mapping of DNA clones specific for CDY and DAZ resulted in a Y-specific but diverse signal pattern within the non-recombining region of the Y-chromosomes of human and great apes. It can be concluded that the non-recombining part of the Y-chromosomes including CDY and DAZ, was exposed to species-specific amplifications, diversifications and rearrangements. Evolutionary fast fixation of any of these variations was possible as long as they did not interfere with male fertility.[1]References
- Comparative mapping of CDY and DAZ in higher primates. Wimmer, R., Kühl, H., Röttger, S., Schempp, W. Cytogenet. Genome Res. (2002) [Pubmed]
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