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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives.

A series of pyrazine and quinoxaline derivatives have been synthesized, and their activity against M. tuberculosis (Mtb) and Mycobacterium avium (MAC) are reported. The 4-acetoxybenzyl ester of pyrazinoic acid and 4'-acetoxybenzyl 2-quinoxalinecarboxylate showed excellent activity against Mtb (MIC ranges of less than 1-6.25 microg/mL) but only modest activity against MAC (MICs of 4-32 microg/mL).[1]


  1. Synthesis and antimycobacterial activity of pyrazine and quinoxaline derivatives. Seitz, L.E., Suling, W.J., Reynolds, R.C. J. Med. Chem. (2002) [Pubmed]
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