Chemical Compound Review:
PYRAZINE pyrazine
Synonyms:
Piazine, pyrazin, Paradiazine, p-Diazine, SureCN5179, ...
- Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands. Ghosh, A.K., Thompson, W.J., Holloway, M.K., McKee, S.P., Duong, T.T., Lee, H.Y., Munson, P.M., Smith, A.M., Wai, J.M., Darke, P.L. J. Med. Chem. (1993)
- Antimitotic agents. Alterations at the 2,3-positions of ethyl (5-amino-1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamates. Temple, C., Rener, G.A., Comber, R.N., Waud, W.R. J. Med. Chem. (1991)
- Induction of rat liver microsomal epoxide hydrolase by thiazole and pyrazine: hydrolysis of 2-cyanoethylene oxide. Kim, S.G., Kedderis, G.L., Batra, R., Novak, R.F. Carcinogenesis (1993)
- Radiolytic and photochemical reduction of the hypoxic cytotoxin 1,2-dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo [1,2-a] pyrido [3,2-e] pyrazine 5-oxide (RB90740) and a potential mechanism for hypoxia-selective toxicity. Naylor, M.A., Sutton, B.M., Nolan, J., O'Neill, P., Fielden, E.M., Adams, G.E., Stratford, I.J. Int. J. Radiat. Oncol. Biol. Phys. (1994)
- The pyrazine-binding protein and olfaction. Bignetti, E., Cattaneo, P., Cavaggioni, A., Damiani, G., Tirindelli, R. Comp. Biochem. Physiol., B (1988)
- Odorant-binding protein: localization to nasal glands and secretions. Pevsner, J., Sklar, P.B., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Isolation and characterization of an olfactory receptor protein for odorant pyrazines. Pevsner, J., Trifiletti, R.R., Strittmatter, S.M., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (1985)
- Inhibition of Na+/Ca2+ exchange in membrane vesicle and papillary muscle preparations from guinea pig heart by analogs of amiloride. Siegl, P.K., Cragoe, E.J., Trumble, M.J., Kaczorowski, G.J. Proc. Natl. Acad. Sci. U.S.A. (1984)
- Thermodynamics of binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the major urinary protein. Bingham, R.J., Findlay, J.B., Hsieh, S.Y., Kalverda, A.P., Kjellberg, A., Perazzolo, C., Phillips, S.E., Seshadri, K., Trinh, C.H., Turnbull, W.B., Bodenhausen, G., Homans, S.W. J. Am. Chem. Soc. (2004)
- Diversity of channels generated by different combinations of epithelial sodium channel subunits. McNicholas, C.M., Canessa, C.M. J. Gen. Physiol. (1997)
- Enhancement of biliary excretion of aflatoxin B(1) and suppression of hepatic ornithine decarboxylase activity by 2-(allylthio)pyrazine in rats. Ha, T.G., Mar, W.C., Kim, S.G., Surh, Y.J., Kim, N.D. Mutat. Res. (1999)
- Schedule dependence, activity against natural metastases, and cross-resistance of pyrazine diazohydroxide (sodium salt, NSC 361456) in preclinical models in vivo. Harrison, S.D., Plowman, J., Dykes, D.J., Waud, W.R., Griswold, D.P. Cancer Chemother. Pharmacol. (1990)
- Spin-gap formation and thermal structural studies in reduced hybrid layered vanadates. Yan, B., Luo, J., Dube, P., Sefat, A.S., Greedan, J.E., Maggard, P.A. Inorganic chemistry. (2006)
- Pharmacokinetic changes of intravenous 2-(allylthio) pyrazine, a chemoprotective agent, in rats with acute renal failure induced by uranyl nitrate. Lee, E.J., Kim, E.J., Kim, Y.G., Chung, H.C., Kim, S.H., Kim, D.H., Lee, I., Kim, S.G., Lee, M.G. Res. Commun. Mol. Pathol. Pharmacol. (2002)
- Traditional GFP-type cyclization and unexpected fragmentation site in a purple chromoprotein from Anemonia sulcata, asFP595. Zagranichny, V.E., Rudenko, N.V., Gorokhovatsky, A.Y., Zakharov, M.V., Balashova, T.A., Arseniev, A.S. Biochemistry (2004)
- Synthesis and antiviral evaluation of certain novel pyrazinoic acid C-nucleosides. Walker, J.A., Liu, W., Wise, D.S., Drach, J.C., Townsend, L.B. J. Med. Chem. (1998)
- Differential expression of microsomal epoxide hydrolase gene by azole heterocycles in rats. Kim, S.G., Jung, K.H., Yang, W.K., Kim, N.D. Biochem. Pharmacol. (1994)
- Structure-activity relationship of amiloride analogs as blockers of epithelial Na channels: I. Pyrazine-ring modifications. Li, J.H., Cragoe, E.J., Lindemann, B. J. Membr. Biol. (1985)
- Tetrahydropyrrolo[1,2-a]quinoxalines and tetrahydropyrrolo[1,2-a]pyrido[3,2-a]pyrazines: vascular smooth muscle relaxants and antihypertensive agents. Abou-Gharbia, M., Freed, M.E., McCaully, R.J., Silver, P.J., Wendt, R.L. J. Med. Chem. (1984)
- Homology between the pyrazine-binding protein from nasal mucosa and major urinary proteins. Cavaggioni, A., Sorbi, R.T., Keen, J.N., Pappin, D.J., Findlay, J.B. FEBS Lett. (1987)
- Fused pyrazine mono-n-oxides as bioreductive drugs. II Cytotoxicity in human cells and oncogenicity in a rodent transformation assay. Langmuir, V.K., Laderoute, K.R., Mendonca, H.L., Sutherland, R.M., Hei, T.K., Liu, S.X., Hall, E.J., Naylor, M.A., Adams, G.E. Int. J. Radiat. Oncol. Biol. Phys. (1996)
- Pyrazine derivatives affect membrane fluidity of vascular smooth muscle microsomes in relation to their biological activity. Nie, S.Q., Kwan, C.Y., Epand, R.M. Eur. J. Pharmacol. (1993)
- Relative substrate activities of structurally related pteridine, quinazoline, and pyrimidine analogs for mouse liver folylpolyglutamate synthetase. Moran, R.G., Colman, P.D., Jones, T.R. Mol. Pharmacol. (1989)
- Potential antimitotic agents. Synthesis of some ethyl benzopyrazin-7-ylcarbamates, ethyl pyrido[3,4-b]pyrazin-7-ylcarbamates, and ethyl pyrido[3,4-e]-as-triazin-7-ylcarbamates. Temple, C., Rener, G.A. J. Med. Chem. (1990)
- Conformational behavior of pyrazine-bridged and mixed-bridged cavitands: a general model for solvent effects on thermal "vase-kite" switching. Roncucci, P., Pirondini, L., Paderni, G., Massera, C., Dalcanale, E., Azov, V.A., Diederich, F. Chemistry (Weinheim an der Bergstrasse, Germany) (2006)
- Activity of n-propyl pyrazinoate against pyrazinamide-resistant Mycobacterium tuberculosis: investigations into mechanism of action of and mechanism of resistance to pyrazinamide. Speirs, R.J., Welch, J.T., Cynamon, M.H. Antimicrob. Agents Chemother. (1995)
- Estrogenic diazenes: heterocyclic non-steroidal estrogens of unusual structure with selectivity for estrogen receptor subtypes. Ghosh, U., Ganessunker, D., Sattigeri, V.J., Carlson, K.E., Mortensen, D.J., Katzenellenbogen, B.S., Katzenellenbogen, J.A. Bioorg. Med. Chem. (2003)
- Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore. Ward, J.S., Merritt, L., Klimkowski, V.J., Lamb, M.L., Mitch, C.H., Bymaster, F.P., Sawyer, B., Shannon, H.E., Olesen, P.H., Honoré, T. J. Med. Chem. (1992)
- New non-peptide endothelin-A receptor antagonists: synthesis, biological properties, and structure-activity relationships of 5-(dimethylamino)-N-pyridyl-,-N-pyrimidinyl-,-N-pyridazinyl-, and -N-pyrazinyl-1-naphthalenesulfonamides. Bradbury, R.H., Bath, C., Butlin, R.J., Dennis, M., Heys, C., Hunt, S.J., James, R., Mortlock, A.A., Sumner, N.F., Tang, E.K., Telford, B., Whiting, E., Wilson, C. J. Med. Chem. (1997)
- Inhibition of monoamine oxidase by analogues of amiloride. Palatý, V., Cragoe, E.J. Mol. Pharmacol. (1989)
- Long-range magnetic order in Mn[N(CN)2]2(pyz) (pyz = pyrazine). Susceptibility, magnetization, specific heat, and neutron diffraction measurements and electronic structure calculations. Manson, J.L., Huang, Q., Lynn, J.W., Koo, H.J., Whangbo, M.H., Bateman, R., Otsuka, T., Wada, N., Argyriou, D.N., Miller, J.S. J. Am. Chem. Soc. (2001)
- A micropuncture study on the renal site of action of ICI 206,970, a unique eukalemic diuretic. Johnston, P.A., Kau, S.T. J. Pharmacol. Exp. Ther. (1993)
- A phase II trial of pyrazine diazohydroxide in patients with disseminated malignant melanoma and no prior chemotherapy--Southwest Oncology Group study. Whitehead, R.P., Unger, J.M., Flaherty, L.E., Kraut, E.H., Mills, G.M., Klein, C.E., Chapman, R.A., Doolittle, G.C., Hammond, N., Sondak, V.K. Investigational new drugs. (2002)
- Inhibition of cytochrome P4502E1 expression by organosulfur compounds allylsulfide, allylmercaptan and allylmethylsulfide in rats. Kwak, M.K., Kim, S.G., Kwak, J.Y., Novak, R.F., Kim, N.D. Biochem. Pharmacol. (1994)