How to flip the (redox) switch.
Redox-sensitive transcription factors such as the E. coli OxyR and S. cerevisiae Yap1, are activated by conformational changes that stem from the post-translational modification of reactive protein thiols. Recent studies provide new insights on how different agents that cause redox stress mediate the activation of transcription through distinct and specific pathways.[1]References
- How to flip the (redox) switch. Georgiou, G. Cell (2002) [Pubmed]
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