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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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4-1 BB ligand--just another costimulating molecule?

Initially, scientific interest in the 4-1BB/4-1BB Ligand system focused on the role of the 4-1BB (CD137) receptor in the costimulation of T cells. More recently, evidence is accumulating that 4-1BBL is more than "just" the ligand for a costimulatory molecule. In this review we discuss the functional properties of 4-1BB Ligand such as its preference for CD8 positive T cells and the differences to costimulation via the B7/CD28 system. Furthermore, the available data regarding its ability to transduce signals bidirectionally, i.e. also back into the ligand bearing cell, its release as a soluble form following shedding from the cell surface, and its role in the interaction of tumor cells with the immune system are reviewed.[1]

References

  1. 4-1 BB ligand--just another costimulating molecule? Salih, H.R., Kiener, P.A., Nüssler, V. International journal of clinical pharmacology and therapeutics. (2002) [Pubmed]
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