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Gene Review

CD276  -  CD276 molecule

Homo sapiens

Synonyms: 4Ig-B7-H3, B7 homolog 3, B7-H3, B7H3, B7RP-2, ...
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Disease relevance of CD276


High impact information on CD276


Chemical compound and disease context of CD276


Biological context of CD276


Anatomical context of CD276

  • B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells, enhances the induction of cytotoxic T cells and selectively stimulates interferon gamma (IFN-gamma) production in the presence of T cell receptor signaling [19].
  • Expression of B7-H3 protein, however, can be induced on dendritic cells (DCs) and monocytes by inflammatory cytokines and a combination of phorbol myristate acetate (PMA) + ionomycin [19].
  • B7-H3 mRNA is not detectable in peripheral blood mononuclear cells, although it is found in various normal tissues and in several tumor cell lines [19].
  • These data suggest that 4Ig-B7-H3 molecules expressed at the tumor cell surface can exert a protective role from natural killer-mediated lysis by interacting with a still undefined inhibitory receptor expressed on natural killer cells [20].
  • B7-DC and B7-H3 inhibit antigen-stimulated lymphocyte activation while B7-H2 serves in a regulatory capacity, often promoting a Th2 immunophenotype [17].

Associations of CD276 with chemical compounds

  • Molecular analysis revealed that the 5B14 mAb-reactive surface glycoprotein corresponded to the recently identified 4Ig-B7-H3 molecule [20].
  • The maturation of MDDCs in the presence of PTX and LPS was characterized by the decreased expression of maturation marker CD83 and costimulatory molecule CD86, as well as lower stimulation of alloreactive T cells compared to the control MDDCs cultivated with LPS alone [21].
  • Inhibitory effect of clarithromycin on costimulatory molecule expression and cytokine production by synovial fibroblast-like cells [22].
  • VLP-induced induction of costimulatory molecule expression, RelB activation and cytokine secretion by DC was blocked by inhibition of NF-kappaB activation, heparin or TLR4 mAb [23].
  • We investigated a potential role for 4-1BB, a costimulatory molecule structurally related to members of the tumor necrosis factor (TNF) receptor family, in the generation and functional activation of CD28(-) CTLs by using human cord blood (CB) cells composed exclusively of naive CD8(+) T cells with few or no CD28(-) CTLs [24].

Physical interactions of CD276


Regulatory relationships of CD276


Other interactions of CD276


Analytical, diagnostic and therapeutic context of CD276


  1. Human recombinant B7-H3 expressed in E. coli enhances T lymphocyte proliferation and IL-10 secretion in vitro. Zhang, G.B., Chen, Y.J., Shi, Q., Ma, H.B., Ge, Y., Wang, Q., Jiang, Z., Xu, Y., Zhang, X.G. Acta Biochim. Biophys. Sin. (Shanghai) (2004) [Pubmed]
  2. Phase I study of the intratumoral administration of recombinant canarypox viruses expressing B7.1 and interleukin 12 in patients with metastatic melanoma. Triozzi, P.L., Allen, K.O., Carlisle, R.R., Craig, M., LoBuglio, A.F., Conry, R.M. Clin. Cancer Res. (2005) [Pubmed]
  3. HIV Coinfection Impairs CD28-Mediated Costimulation of Hepatitis C Virus-Specific CD8 Cells. Yonkers, N.L., Rodriguez, B., Post, A.B., Asaad, R., Jones, L., Lederman, M.M., Lehmann, P.V., Anthony, D.D. J. Infect. Dis. (2006) [Pubmed]
  4. Trypanosoma cruzi Infection Induces Differential Modulation of Costimulatory Molecules and Cytokines by Monocytes and T Cells from Patients with Indeterminate and Cardiac Chagas' Disease. Souza, P.E., Rocha, M.O., Menezes, C.A., Coelho, J.S., Chaves, A.C., Gollob, K.J., Dutra, W.O. Infect. Immun. (2007) [Pubmed]
  5. Immunobiological characterization of N -nitrosomethylurea-induced rat breast carcinomas: tumoral IL-10 expression as a possible immune escape mechanism. Hill, M., Bausero, M., Mazal, D., Ménoret, S., Khalife, J., Anegón, I., Osinaga, E. Breast Cancer Res. Treat. (2004) [Pubmed]
  6. Human muscle cells express the costimulatory molecule B7-H3, which modulates muscle-immune interactions. Waschbisch, A., Wintterle, S., Lochmüller, H., Walter, M.C., Wischhusen, J., Kieseier, B.C., Wiendl, H. Arthritis Rheum. (2008) [Pubmed]
  7. Sarcoidosis is associated with a truncating splice site mutation in BTNL2. Valentonyte, R., Hampe, J., Huse, K., Rosenstiel, P., Albrecht, M., Stenzel, A., Nagy, M., Gaede, K.I., Franke, A., Haesler, R., Koch, A., Lengauer, T., Seegert, D., Reiling, N., Ehlers, S., Schwinger, E., Platzer, M., Krawczak, M., Müller-Quernheim, J., Schürmann, M., Schreiber, S. Nat. Genet. (2005) [Pubmed]
  8. Signals and signs for lymphocyte responses. Janeway, C.A., Bottomly, K. Cell (1994) [Pubmed]
  9. Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease. Sun, Y., Chen, H.M., Subudhi, S.K., Chen, J., Koka, R., Chen, L., Fu, Y.X. Nat. Med. (2002) [Pubmed]
  10. Costimulatory regulation of T cell function. Chambers, C.A., Allison, J.P. Curr. Opin. Cell Biol. (1999) [Pubmed]
  11. Soluble CD86 is a costimulatory molecule for human T lymphocytes. Jeannin, P., Magistrelli, G., Aubry, J.P., Caron, G., Gauchat, J.F., Renno, T., Herbault, N., Goetsch, L., Blaecke, A., Dietrich, P.Y., Bonnefoy, J.Y., Delneste, Y. Immunity (2000) [Pubmed]
  12. Induction of costimulatory molecule B7 in M12 B lymphomas by cAMP or MHC-restricted T cell interaction. Watts, T.H., Alaverdi, N., Wade, W.F., Linsley, P.S. J. Immunol. (1993) [Pubmed]
  13. Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs. Lu, Q., Wu, A., Richardson, B.C. J. Immunol. (2005) [Pubmed]
  14. Arsenic trioxide synergizes with B7H3-mediated immunotherapy to eradicate hepatocellular carcinomas. Luo, L., Qiao, H., Meng, F., Dong, X., Zhou, B., Jiang, H., Kanwar, J.R., Krissansen, G.W., Sun, X. Int. J. Cancer (2006) [Pubmed]
  15. The role of costimulatory molecules (B7-1 and B7-2) on allergen-stimulated B cells in cedar pollinosis subjects. Morikawa, H., Nagashima, S. Clin. Exp. Allergy (2000) [Pubmed]
  16. Human CD4+CD25high Regulatory T Cells Modulate Myeloid but Not Plasmacytoid Dendritic Cells Activation. Houot, R., Perrot, I., Garcia, E., Durand, I., Lebecque, S. J. Immunol. (2006) [Pubmed]
  17. The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are differentially expressed across gestation in the human placenta. Petroff, M.G., Kharatyan, E., Torry, D.S., Holets, L. Am. J. Pathol. (2005) [Pubmed]
  18. Characterization of mouse and human B7-H3 genes. Sun, M., Richards, S., Prasad, D.V., Mai, X.M., Rudensky, A., Dong, C. J. Immunol. (2002) [Pubmed]
  19. B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Chapoval, A.I., Ni, J., Lau, J.S., Wilcox, R.A., Flies, D.B., Liu, D., Dong, H., Sica, G.L., Zhu, G., Tamada, K., Chen, L. Nat. Immunol. (2001) [Pubmed]
  20. Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis. Castriconi, R., Dondero, A., Augugliaro, R., Cantoni, C., Carnemolla, B., Sementa, A.R., Negri, F., Conte, R., Corrias, M.V., Moretta, L., Moretta, A., Bottino, C. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  21. Effect of pentoxifylline on differentiation and maturation of human monocyte-derived dendritic cells in vitro. Vukani??, Z.S., Coli??, M., Dimitrijevi??, M. Int. Immunopharmacol. (2007) [Pubmed]
  22. Inhibitory effect of clarithromycin on costimulatory molecule expression and cytokine production by synovial fibroblast-like cells. Matsuoka, N., Eguchi, K., Kawakami, A., Tsuboi, M., Kawabe, Y., Aoyagi, T., Nagataki, S. Clin. Exp. Immunol. (1996) [Pubmed]
  23. Activation of dendritic cells by human papillomavirus-like particles through TLR4 and NF-kappaB-mediated signalling, moderated by TGF-beta. Yan, M., Peng, J., Jabbar, I.A., Liu, X., Filgueira, L., Frazer, I.H., Thomas, R. Immunol. Cell Biol. (2005) [Pubmed]
  24. Role of 4-1BB (CD137) in the functional activation of cord blood CD28(-)CD8(+) T cells. Kim, Y.J., Brutkiewicz, R.R., Broxmeyer, H.E. Blood (2002) [Pubmed]
  25. Regulation of major histocompatibility complex class II antigens on human alveolar macrophages by granulocyte-macrophage colony-stimulating factor in the presence of glucocorticoids. Caulfield, J.J., Fernandez, M.H., Sousa, A.R., Lane, S.J., Lee, T.H., Hawrylowicz, C.M. Immunology (1999) [Pubmed]
  26. Altered phenotype and function of blood dendritic cells in multiple sclerosis are modulated by IFN-beta and IL-10. Huang, Y.M., Stoyanova, N., Jin, Y.P., Teleshova, N., Hussien, Y., Xiao, B.G., Fredrikson, S., Link, H. Clin. Exp. Immunol. (2001) [Pubmed]
  27. Polarized expression and function of the costimulatory molecule CD58 on human intestinal epithelial cells. Framson, P.E., Cho, D.H., Lee, L.Y., Hershberg, R.M. Gastroenterology (1999) [Pubmed]
  28. Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells. Levy, O., Suter, E.E., Miller, R.L., Wessels, M.R. Blood (2006) [Pubmed]
  29. Identification of a promoter element that regulates tissue-specific expression of the human CD80 (B7.1) gene. Fong, T.C., Wu, Y., Kipps, T.J. J. Immunol. (1996) [Pubmed]
  30. Biochemical and functional characterization of three activated macrophage populations. Edwards, J.P., Zhang, X., Frauwirth, K.A., Mosser, D.M. J. Leukoc. Biol. (2006) [Pubmed]
  31. Regulation of TCR-mediated T cell activation by TNF-RII. Aspalter, R.M., Eibl, M.M., Wolf, H.M. J. Leukoc. Biol. (2003) [Pubmed]
  32. Self-tolerance in the immune privileged CNS: lessons from the entorhinal cortex lesion model. Kwidzinski, E., Mutlu, L.K., Kovac, A.D., Bunse, J., Goldmann, J., Mahlo, J., Aktas, O., Zipp, F., Kamradt, T., Nitsch, R., Bechmann, I. J. Neural Transm. Suppl. (2003) [Pubmed]
  33. Expression of recombinant human ICOS and in vitro characterization of its bioactivity on B lymphocytes. Deng, Z.B., Lu, C.M., Huang, W.D., Shen, L.Q., Zhu, W., Ma, H.B., Fan, P.S., Zhang, X.G. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (2003) [Pubmed]
  34. Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss. Ling, V., Wu, P.W., Spaulding, V., Kieleczawa, J., Luxenberg, D., Carreno, B.M., Collins, M. Genomics (2003) [Pubmed]
  35. A Costimulatory Function for T Cell CD40. Munroe, M.E., Bishop, G.A. J. Immunol. (2007) [Pubmed]
  36. B7H1-Ig Fusion Protein Activates the CD4+ IFN-{gamma} Receptor+ Type 1 T Regulatory Subset through IFN-{gamma}-Secreting Th1 Cells. Ding, Q., Lu, L., Wang, B., Zhou, Y., Jiang, Y., Zhou, X., Xin, L., Jiao, Z., Chou, K.Y. J. Immunol. (2006) [Pubmed]
  37. Importance of the inducible costimulator molecule for the induction of allergic immune responses and its decreased expression on T helper cells after venom immunotherapy. Bellinghausen, I., Klostermann, B., Böttcher, I., Knop, J., Saloga, J. Immunology (2004) [Pubmed]
  38. Inhibitory effects of interleukin-10 on synovial cells of rheumatoid arthritis. Kawakami, A., Eguchi, K., Matsuoka, N., Tsuboi, M., Urayama, S., Kawabe, Y., Aoyagi, T., Maeda, K., Nagataki, S. Immunology (1997) [Pubmed]
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