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Willson, T.M.

RORalpha: an orphan nuclear receptor on a high-cholesterol diet.

A high-resolution X-ray crystal structure of the retinoic acid receptor-related orphan receptor (RORalpha; NR1F1), which reveals a molecule of cholesterol within the ligand binding pocket, is a breakthrough in functional analysis of this orphan nuclear receptor.[1]

References

RORalpha: an orphan nuclear receptor on a high-cholesterol diet. Willson, T.M. Structure (Camb.) (2002) [Pubmed]

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