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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

2,5-hexanedione-induced testicular injury.

Now in its third decade of mechanistic investigation, testicular injury caused by 2,5-hexanedione (2,5-HD) exposure is a well-studied model with a rich database. The development of this model reflects the larger changes that have moved biology from a branch of chemistry into the molecular age. Critically examined in this review is the proposed mechanism for 2,5-HD-induced testicular injury in which germ cell maturation is disrupted owing to alterations in Sertoli cell microtubule-mediated functions. The goal is to evaluate the technical and conceptual approaches used to assess 2,5-HD-induced testicular injury, to highlight unanswered questions, and to identify fruitful avenues of future research.[1]


  1. 2,5-hexanedione-induced testicular injury. Boekelheide, K., Fleming, S.L., Allio, T., Embree-Ku, M.E., Hall, S.J., Johnson, K.J., Kwon, E.J., Patel, S.R., Rasoulpour, R.J., Schoenfeld, H.A., Thompson, S. Annu. Rev. Pharmacol. Toxicol. (2003) [Pubmed]
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