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Chemical Compound Review

Diacetonyl     hexane-2,5-dione

Synonyms: ACAN, AGN-PC-0D783O, NSC-7621, ACMC-1BPT9, CCRIS 2919, ...
 
 
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Disease relevance of NSC 7621

 

Psychiatry related information on NSC 7621

 

High impact information on NSC 7621

 

Chemical compound and disease context of NSC 7621

 

Biological context of NSC 7621

 

Anatomical context of NSC 7621

 

Associations of NSC 7621 with other chemical compounds

 

Gene context of NSC 7621

 

Analytical, diagnostic and therapeutic context of NSC 7621

References

  1. Sensitivity to 2,5-hexanedione of neurofilaments in neuroblastoma cell line SK-N-SH increases during differentiation. Heijink, E., Bolhuis, P.A., de Wolff, F.A. J. Neuropathol. Exp. Neurol. (1995) [Pubmed]
  2. Leuprolide, a gonadotropin-releasing hormone agonist, reestablishes spermatogenesis after 2,5-hexanedione-induced irreversible testicular injury in the rat, resulting in normalized stem cell factor expression. Blanchard, K.T., Lee, J., Boekelheide, K. Endocrinology (1998) [Pubmed]
  3. Pyridoxamine: an extremely potent scavenger of 1,4-dicarbonyls. Amarnath, V., Amarnath, K., Amarnath, K., Davies, S., Roberts, L.J. Chem. Res. Toxicol. (2004) [Pubmed]
  4. Cell body responses to axonal injury: traumatic axotomy versus toxic neuropathy. Sterman, A.B., Delannoy, M.R. Exp. Neurol. (1985) [Pubmed]
  5. Axonal atrophy is a specific component of 2,5-hexanedione peripheral neuropathy. Lehning, E.J., Dyer, K.S., Jortner, B.S., LoPachin, R.M. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
  6. Early spatial memory deficit induced by 2,5-hexanedione in the rat. Carney, R., Dardis, C., Cullen, W.K., Felipo, V., Anwyl, R., Rowan, M.J. Toxicol. Lett. (2002) [Pubmed]
  7. Neurotoxic effects of combined treatment of 2,5-hexanedione and triethyllead chloride. Lapadula, D.M., Tilson, H.A., Campbell, G., Abou-Donia, M.B. Journal of toxicology and environmental health. (1987) [Pubmed]
  8. Giant axonal neuropathy: acceleration of neurofilament transport in optic axons. Monaco, S., Autilio-Gambetti, L., Zabel, D., Gambetti, P. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  9. Hexacarbon neuropathy: cell body changes are early, dynamic, and specific. Sterman, A.B. Ann. Neurol. (1984) [Pubmed]
  10. Cytoskeletal disorganization induced by local application of beta, beta'-iminodipropionitrile and 2,5-hexanedione. Griffin, J.W., Fahnestock, K.E., Price, D.L., Cork, L.C. Ann. Neurol. (1983) [Pubmed]
  11. Pathogenetic studies of hexane and carbon disulfide neurotoxicity. Graham, D.G., Amarnath, V., Valentine, W.M., Pyle, S.J., Anthony, D.C. Crit. Rev. Toxicol. (1995) [Pubmed]
  12. Acrylamide and 2,5-hexanedione induce collapse of neurofilaments in SH-SY5Y human neuroblastoma cells to form perikaryal inclusion bodies. Hartley, C.L., Anderson, V.E., Anderton, B.H., Robertson, J., Anderson, B.H. Neuropathol. Appl. Neurobiol. (1997) [Pubmed]
  13. Changes of n-hexane metabolites in urine of rats exposed to various concentrations of n-hexane and to its mixture with toluene or MEK. Iwata, M., Takeuchi, Y., Hisanaga, N., Ono, Y. International archives of occupational and environmental health. (1983) [Pubmed]
  14. Urinary excretion of 2,5-hexanedione and peripheral polyneuropathies workers exposed to hexane. Governa, M., Calisti, R., Coppa, G., Tagliavento, G., Colombi, A., Troni, W. Journal of toxicology and environmental health. (1987) [Pubmed]
  15. Comparative study of 2,5-hexanediol and 2,5-hexanedione induced thymic toxicity in weanling and adult rats. Singh, K.P., Upreti, R.K., Saxena, A.K., Shanker, R. Indian J. Exp. Biol. (1986) [Pubmed]
  16. The Fas system is a key regulator of germ cell apoptosis in the testis. Lee, J., Richburg, J.H., Younkin, S.C., Boekelheide, K. Endocrinology (1997) [Pubmed]
  17. Stem cell kinetics in rat testis after irreversible injury induced by 2,5-hexanedione. Allard, E.K., Hall, S.J., Boekelheide, K. Biol. Reprod. (1995) [Pubmed]
  18. Evidence for multiple mechanisms responsible for 2,5-hexanedione-induced neuropathy. Lapadula, D.M., Suwita, E., Abou-Donia, M.B. Brain Res. (1988) [Pubmed]
  19. Neurotoxicity and protein binding of 2,5-hexanedione in the hen. DeCaprio, A.P., Strominger, N.L., Weber, P. Toxicol. Appl. Pharmacol. (1983) [Pubmed]
  20. Evidence that formation of an intermediate filament-protein complex plays a primary role in aggregation of neurofilaments, glial fibrillary acidic protein (GFAP)-filaments and vimentin-filaments by 2,5-hexanedione. Durham, H.D., Salera, I., Dahrouge, S. J. Neuropathol. Exp. Neurol. (1989) [Pubmed]
  21. Aggregation of intermediate filaments by 2,5-hexanedione: comparison of effects on neurofilaments, GFAP-filaments and vimentin-filaments in dissociated cultures of mouse spinal cord-dorsal root ganglia. Durham, H.D. J. Neuropathol. Exp. Neurol. (1988) [Pubmed]
  22. Cell body remodeling during dying-back axonopathy: DRG changes during advanced disease. Sterman, A.B. J. Neuropathol. Exp. Neurol. (1982) [Pubmed]
  23. 2,5-Hexanedione modifies skeletal proteins of the red blood cells and increases the binding of hemoglobin to the membrane. Mallozzi, C., Scorza, G., Frontali, N., Minetti, M. Biochem. Pharmacol. (1989) [Pubmed]
  24. The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis. Lee, J., Richburg, J.H., Shipp, E.B., Meistrich, M.L., Boekelheide, K. Endocrinology (1999) [Pubmed]
  25. Neurotoxicity of acrylamide and 2,5-hexanedione in rats evaluated using a functional observational battery and pathological examination. Shell, L., Rozum, M., Jortner, B.S., Ehrich, M. Neurotoxicology and teratology. (1992) [Pubmed]
  26. Analysis of n-hexane, 2-hexanone, 2,5-hexanedione, and related chemicals by capillary gas chromatography and high-performance liquid chromatography. Nomeir, A.A., Abou-Donia, M.B. Anal. Biochem. (1985) [Pubmed]
  27. Further observations on in vitro and in vivo effects of 2,5-hexanedione on glyceraldehyde-3-phosphate dehydrogenase. Sabri, M.I. Arch. Toxicol. (1984) [Pubmed]
  28. Functional Cyp2e1 is required for substantial in vivo formation of 2,5-hexanedione from n-hexane in the mouse. Iba, M.M., Fung, J., Gonzalez, F.J. Arch. Toxicol. (2000) [Pubmed]
  29. 2,5-hexanedione aggregates vimentin-, but not keratin-, intermediate filaments of PtK1 cells. Durham, H.D. Cell Biol. Int. Rep. (1987) [Pubmed]
  30. Slow axonal transport is impaired by intrathecal 2,5-hexanedione. Hammond-Tooke, G.D. Exp. Neurol. (1992) [Pubmed]
  31. Determination of 2,5-hexanedione in urine and serum by gas chromatography after derivatization with O-(pentafluorobenzyl)hydroxylamine and solid-phase extraction. Kezić, S., Monster, A.C. J. Chromatogr. (1991) [Pubmed]
  32. Rapid and sensitive determination of urinary 2,5-hexanedione by reversed-phase high-performance liquid chromatography. Colombini, M.P., Carrai, P., Fuoco, R., Abete, C. J. Chromatogr. (1992) [Pubmed]
  33. The automated analysis of coordinated hindlimb movement in rats during acute and prolonged exposure to toxic agents. Kulig, B.M., Vanwersch, R.A., Wolthuis, O.L. Toxicol. Appl. Pharmacol. (1985) [Pubmed]
  34. Lack of evidence for the size principle of selective vulnerability of axons in toxic neuropathies. I. The effects of subcutaneous injections of 2,5-hexanedione on behavior and muscle spindle function. De Rojas, T.C., Goldstein, B.D. Toxicol. Appl. Pharmacol. (1990) [Pubmed]
 
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