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Chemical Compound Review

Diacetonyl     hexane-2,5-dione

Synonyms: ACAN, AGN-PC-0D783O, NSC-7621, ACMC-1BPT9, CCRIS 2919, ...
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Disease relevance of NSC 7621


Psychiatry related information on NSC 7621


High impact information on NSC 7621


Chemical compound and disease context of NSC 7621


Biological context of NSC 7621


Anatomical context of NSC 7621


Associations of NSC 7621 with other chemical compounds


Gene context of NSC 7621


Analytical, diagnostic and therapeutic context of NSC 7621


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  2. Leuprolide, a gonadotropin-releasing hormone agonist, reestablishes spermatogenesis after 2,5-hexanedione-induced irreversible testicular injury in the rat, resulting in normalized stem cell factor expression. Blanchard, K.T., Lee, J., Boekelheide, K. Endocrinology (1998) [Pubmed]
  3. Pyridoxamine: an extremely potent scavenger of 1,4-dicarbonyls. Amarnath, V., Amarnath, K., Amarnath, K., Davies, S., Roberts, L.J. Chem. Res. Toxicol. (2004) [Pubmed]
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  12. Acrylamide and 2,5-hexanedione induce collapse of neurofilaments in SH-SY5Y human neuroblastoma cells to form perikaryal inclusion bodies. Hartley, C.L., Anderson, V.E., Anderton, B.H., Robertson, J., Anderson, B.H. Neuropathol. Appl. Neurobiol. (1997) [Pubmed]
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  22. Cell body remodeling during dying-back axonopathy: DRG changes during advanced disease. Sterman, A.B. J. Neuropathol. Exp. Neurol. (1982) [Pubmed]
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  24. The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis. Lee, J., Richburg, J.H., Shipp, E.B., Meistrich, M.L., Boekelheide, K. Endocrinology (1999) [Pubmed]
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  28. Functional Cyp2e1 is required for substantial in vivo formation of 2,5-hexanedione from n-hexane in the mouse. Iba, M.M., Fung, J., Gonzalez, F.J. Arch. Toxicol. (2000) [Pubmed]
  29. 2,5-hexanedione aggregates vimentin-, but not keratin-, intermediate filaments of PtK1 cells. Durham, H.D. Cell Biol. Int. Rep. (1987) [Pubmed]
  30. Slow axonal transport is impaired by intrathecal 2,5-hexanedione. Hammond-Tooke, G.D. Exp. Neurol. (1992) [Pubmed]
  31. Determination of 2,5-hexanedione in urine and serum by gas chromatography after derivatization with O-(pentafluorobenzyl)hydroxylamine and solid-phase extraction. Kezić, S., Monster, A.C. J. Chromatogr. (1991) [Pubmed]
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  33. The automated analysis of coordinated hindlimb movement in rats during acute and prolonged exposure to toxic agents. Kulig, B.M., Vanwersch, R.A., Wolthuis, O.L. Toxicol. Appl. Pharmacol. (1985) [Pubmed]
  34. Lack of evidence for the size principle of selective vulnerability of axons in toxic neuropathies. I. The effects of subcutaneous injections of 2,5-hexanedione on behavior and muscle spindle function. De Rojas, T.C., Goldstein, B.D. Toxicol. Appl. Pharmacol. (1990) [Pubmed]
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