Chemical Compound Review:
Diacetonyl hexane-2,5-dione
Synonyms:
ACAN, AGN-PC-0D783O, NSC-7621, ACMC-1BPT9, CCRIS 2919, ...
- Sensitivity to 2,5-hexanedione of neurofilaments in neuroblastoma cell line SK-N-SH increases during differentiation. Heijink, E., Bolhuis, P.A., de Wolff, F.A. J. Neuropathol. Exp. Neurol. (1995)
- Leuprolide, a gonadotropin-releasing hormone agonist, reestablishes spermatogenesis after 2,5-hexanedione-induced irreversible testicular injury in the rat, resulting in normalized stem cell factor expression. Blanchard, K.T., Lee, J., Boekelheide, K. Endocrinology (1998)
- Pyridoxamine: an extremely potent scavenger of 1,4-dicarbonyls. Amarnath, V., Amarnath, K., Amarnath, K., Davies, S., Roberts, L.J. Chem. Res. Toxicol. (2004)
- Cell body responses to axonal injury: traumatic axotomy versus toxic neuropathy. Sterman, A.B., Delannoy, M.R. Exp. Neurol. (1985)
- Axonal atrophy is a specific component of 2,5-hexanedione peripheral neuropathy. Lehning, E.J., Dyer, K.S., Jortner, B.S., LoPachin, R.M. Toxicol. Appl. Pharmacol. (1995)
- Early spatial memory deficit induced by 2,5-hexanedione in the rat. Carney, R., Dardis, C., Cullen, W.K., Felipo, V., Anwyl, R., Rowan, M.J. Toxicol. Lett. (2002)
- Neurotoxic effects of combined treatment of 2,5-hexanedione and triethyllead chloride. Lapadula, D.M., Tilson, H.A., Campbell, G., Abou-Donia, M.B. Journal of toxicology and environmental health. (1987)
- Giant axonal neuropathy: acceleration of neurofilament transport in optic axons. Monaco, S., Autilio-Gambetti, L., Zabel, D., Gambetti, P. Proc. Natl. Acad. Sci. U.S.A. (1985)
- Hexacarbon neuropathy: cell body changes are early, dynamic, and specific. Sterman, A.B. Ann. Neurol. (1984)
- Cytoskeletal disorganization induced by local application of beta, beta'-iminodipropionitrile and 2,5-hexanedione. Griffin, J.W., Fahnestock, K.E., Price, D.L., Cork, L.C. Ann. Neurol. (1983)
- Pathogenetic studies of hexane and carbon disulfide neurotoxicity. Graham, D.G., Amarnath, V., Valentine, W.M., Pyle, S.J., Anthony, D.C. Crit. Rev. Toxicol. (1995)
- Acrylamide and 2,5-hexanedione induce collapse of neurofilaments in SH-SY5Y human neuroblastoma cells to form perikaryal inclusion bodies. Hartley, C.L., Anderson, V.E., Anderton, B.H., Robertson, J., Anderson, B.H. Neuropathol. Appl. Neurobiol. (1997)
- Changes of n-hexane metabolites in urine of rats exposed to various concentrations of n-hexane and to its mixture with toluene or MEK. Iwata, M., Takeuchi, Y., Hisanaga, N., Ono, Y. International archives of occupational and environmental health. (1983)
- Urinary excretion of 2,5-hexanedione and peripheral polyneuropathies workers exposed to hexane. Governa, M., Calisti, R., Coppa, G., Tagliavento, G., Colombi, A., Troni, W. Journal of toxicology and environmental health. (1987)
- Comparative study of 2,5-hexanediol and 2,5-hexanedione induced thymic toxicity in weanling and adult rats. Singh, K.P., Upreti, R.K., Saxena, A.K., Shanker, R. Indian J. Exp. Biol. (1986)
- The Fas system is a key regulator of germ cell apoptosis in the testis. Lee, J., Richburg, J.H., Younkin, S.C., Boekelheide, K. Endocrinology (1997)
- Stem cell kinetics in rat testis after irreversible injury induced by 2,5-hexanedione. Allard, E.K., Hall, S.J., Boekelheide, K. Biol. Reprod. (1995)
- Evidence for multiple mechanisms responsible for 2,5-hexanedione-induced neuropathy. Lapadula, D.M., Suwita, E., Abou-Donia, M.B. Brain Res. (1988)
- Neurotoxicity and protein binding of 2,5-hexanedione in the hen. DeCaprio, A.P., Strominger, N.L., Weber, P. Toxicol. Appl. Pharmacol. (1983)
- Evidence that formation of an intermediate filament-protein complex plays a primary role in aggregation of neurofilaments, glial fibrillary acidic protein (GFAP)-filaments and vimentin-filaments by 2,5-hexanedione. Durham, H.D., Salera, I., Dahrouge, S. J. Neuropathol. Exp. Neurol. (1989)
- Aggregation of intermediate filaments by 2,5-hexanedione: comparison of effects on neurofilaments, GFAP-filaments and vimentin-filaments in dissociated cultures of mouse spinal cord-dorsal root ganglia. Durham, H.D. J. Neuropathol. Exp. Neurol. (1988)
- Cell body remodeling during dying-back axonopathy: DRG changes during advanced disease. Sterman, A.B. J. Neuropathol. Exp. Neurol. (1982)
- 2,5-Hexanedione modifies skeletal proteins of the red blood cells and increases the binding of hemoglobin to the membrane. Mallozzi, C., Scorza, G., Frontali, N., Minetti, M. Biochem. Pharmacol. (1989)
- The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis. Lee, J., Richburg, J.H., Shipp, E.B., Meistrich, M.L., Boekelheide, K. Endocrinology (1999)
- Neurotoxicity of acrylamide and 2,5-hexanedione in rats evaluated using a functional observational battery and pathological examination. Shell, L., Rozum, M., Jortner, B.S., Ehrich, M. Neurotoxicology and teratology. (1992)
- Analysis of n-hexane, 2-hexanone, 2,5-hexanedione, and related chemicals by capillary gas chromatography and high-performance liquid chromatography. Nomeir, A.A., Abou-Donia, M.B. Anal. Biochem. (1985)
- Further observations on in vitro and in vivo effects of 2,5-hexanedione on glyceraldehyde-3-phosphate dehydrogenase. Sabri, M.I. Arch. Toxicol. (1984)
- Functional Cyp2e1 is required for substantial in vivo formation of 2,5-hexanedione from n-hexane in the mouse. Iba, M.M., Fung, J., Gonzalez, F.J. Arch. Toxicol. (2000)
- 2,5-hexanedione aggregates vimentin-, but not keratin-, intermediate filaments of PtK1 cells. Durham, H.D. Cell Biol. Int. Rep. (1987)
- Slow axonal transport is impaired by intrathecal 2,5-hexanedione. Hammond-Tooke, G.D. Exp. Neurol. (1992)
- Determination of 2,5-hexanedione in urine and serum by gas chromatography after derivatization with O-(pentafluorobenzyl)hydroxylamine and solid-phase extraction. Kezić, S., Monster, A.C. J. Chromatogr. (1991)
- Rapid and sensitive determination of urinary 2,5-hexanedione by reversed-phase high-performance liquid chromatography. Colombini, M.P., Carrai, P., Fuoco, R., Abete, C. J. Chromatogr. (1992)
- The automated analysis of coordinated hindlimb movement in rats during acute and prolonged exposure to toxic agents. Kulig, B.M., Vanwersch, R.A., Wolthuis, O.L. Toxicol. Appl. Pharmacol. (1985)
- Lack of evidence for the size principle of selective vulnerability of axons in toxic neuropathies. I. The effects of subcutaneous injections of 2,5-hexanedione on behavior and muscle spindle function. De Rojas, T.C., Goldstein, B.D. Toxicol. Appl. Pharmacol. (1990)