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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

DDAVP in the treatment of central diabetes insipidus.

DDAVP, 1-desamino-8-d-arginine-vasopressin, is a synthetic analogue of vasopressin with increased antidiuretic activity and decreased pressor activity. Whereas the antidiuretic-to-pressor ratio of arginine vasopressin is 1, the antidiuretic-to-pressor ratio of DDAVP is 4000. When administered as an intranasal spray, 5 to 20 mug of DDAVP produced eight to 20 hours of antidiuresis in patients with complete central diabetes insipidus. The minimum recommended therapeutic dose resulted in a maximum antidiuresis in most patients. No side effects of the drug were noted in clinical trials. DDAVP thus gives promise of becoming the standard treatment of severe central diabetes insipidus.[1]


  1. DDAVP in the treatment of central diabetes insipidus. Robinson, A.G. N. Engl. J. Med. (1976) [Pubmed]
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