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Chemical Compound Review

Adiuretin     1-[[10-(2- aminocarbonylethyl)-7...

Synonyms: Minirin, DDAVP, DESMOPRESSIN, Adiuretin SD, Deamino Arginine Vasopressin, ...
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Disease relevance of DESMOPRESSIN


Psychiatry related information on DESMOPRESSIN


High impact information on DESMOPRESSIN


Chemical compound and disease context of DESMOPRESSIN


Biological context of DESMOPRESSIN


Anatomical context of DESMOPRESSIN


Associations of DESMOPRESSIN with other chemical compounds


Gene context of DESMOPRESSIN


Analytical, diagnostic and therapeutic context of DESMOPRESSIN



  1. Platelet aggregation induced by DDAVP in platelet-type von Willebrand's disease. Takahashi, H., Nagayama, R., Hattori, A., Shibata, A. N. Engl. J. Med. (1984) [Pubmed]
  2. Myocardial infarction in a patient with hemophilia treated with DDAVP. Bond, L., Bevan, D. N. Engl. J. Med. (1988) [Pubmed]
  3. A study of induced hyponatremia in the prevention and treatment of sickle-cell crisis. Rosa, R.M., Bierer, B.E., Thomas, R., Stoff, J.S., Kruskall, M., Robinson, S., Bunn, H.F., Epstein, F.H. N. Engl. J. Med. (1980) [Pubmed]
  4. DDAVP in the treatment of central diabetes insipidus. Robinson, A.G. N. Engl. J. Med. (1976) [Pubmed]
  5. Platelet aggregation induced by 1-desamino-8-D-arginine vasopressin (DDAVP) in Type IIB von Willebrand's disease. Holmberg, L., Nilsson, I.M., Borge, L., Gunnarsson, M., Sjörin, E. N. Engl. J. Med. (1983) [Pubmed]
  6. Desmopressin in the treatment of nocturia: a double-blind, placebo-controlled study. van Kerrebroeck, P., Rezapour, M., Cortesse, A., Thüroff, J., Riis, A., Nørgaard, J.P. Eur. Urol. (2007) [Pubmed]
  7. Aggravation of subclinical diabetes insipidus during pregnancy. Iwasaki, Y., Oiso, Y., Kondo, K., Takagi, S., Takatsuki, K., Hasegawa, H., Ishikawa, K., Fujimura, Y., Kazeto, S., Tomita, A. N. Engl. J. Med. (1991) [Pubmed]
  8. Desmopressin for nocturnal enuresis in nephrogenic diabetes insipidus. Müller, D., Marr, N., Ankermann, T., Eggert, P., Deen, P.M. Lancet (2002) [Pubmed]
  9. Effects of 1-desamo-8-D-arginine vasopressin on behaviour and cognition in primary affective disorder. Gold, P.W., Weingartner, H., Ballenger, J.C., Goodwin, F.K., Post, R.M. Lancet (1979) [Pubmed]
  10. Paranoid psychosis after DDAVP therapy for Alzheimer's dementia. Collins, G.B., Marzewski, D.J., Rollins, M.B. Lancet (1981) [Pubmed]
  11. Desmopressin in post-traumatic amnesia. Jenkins, J.S., Mather, H.M., Coughlan, A.K., Jenkins, D.G. Lancet (1979) [Pubmed]
  12. Urinary excretion of aquaporin-2 in patients with diabetes insipidus. Kanno, K., Sasaki, S., Hirata, Y., Ishikawa, S., Fushimi, K., Nakanishi, S., Bichet, D.G., Marumo, F. N. Engl. J. Med. (1995) [Pubmed]
  13. A trial of desmopressin (1-desamino-8-D-arginine vasopressin) to reduce blood loss in uncomplicated cardiac surgery. Hackmann, T., Gascoyne, R.D., Naiman, S.C., Growe, G.H., Burchill, L.D., Jamieson, W.R., Sheps, S.B., Schechter, M.T., Townsend, G.E. N. Engl. J. Med. (1989) [Pubmed]
  14. Pharmacological strategies to decrease excessive blood loss in cardiac surgery: a meta-analysis of clinically relevant endpoints. Levi, M., Cromheecke, M.E., de Jonge, E., Prins, M.H., de Mol, B.J., Briët, E., Büller, H.R. Lancet (1999) [Pubmed]
  15. Restoration of suppressed baroreflex sensitivity in rats with hereditary diabetes insipidus (Brattleboro rats) by arginine-vasopressin and DDAVP. Imai, Y., Nolan, P.L., Johnston, C.I. Circ. Res. (1983) [Pubmed]
  16. Hormonal dependence of the effects of metabolic encephalopathy on cerebral perfusion and oxygen utilization in the rat. Kozniewska, E., Roberts, T.P., Vexler, Z.S., Oseka, M., Kucharczyk, J., Arieff, A.I. Circ. Res. (1995) [Pubmed]
  17. Desmopressin: a nontransfusional hemostatic agent. Mannucci, P.M. Annu. Rev. Med. (1990) [Pubmed]
  18. Randomized controlled trial of desmopressin plus terlipressin vs. terlipressin alone for the treatment of acute variceal hemorrhage in cirrhotic patients: a multicenter, double-blind study. New Italian Endoscopic Club. de Franchis, R., Arcidiacono, P.G., Carpinelli, L., Andreoni, B., Cestari, L., Brunati, S., Zambelli, A., Battaglia, G., Mannucci, P.M. Hepatology (1993) [Pubmed]
  19. Deamino-8-D-arginine vasopressin shortens the bleeding time in uremia. Mannucci, P.M., Remuzzi, G., Pusineri, F., Lombardi, R., Valsecchi, C., Mecca, G., Zimmerman, T.S. N. Engl. J. Med. (1983) [Pubmed]
  20. Administration of desmopressin in brain-dead donors and renal function in kidney recipients. Guesde, R., Barrou, B., Leblanc, I., Ourahma, S., Goarin, J.P., Coriat, P., Riou, B. Lancet (1998) [Pubmed]
  21. Use of point-of-care test in identification of patients who can benefit from desmopressin during cardiac surgery: a randomised controlled trial. Despotis, G.J., Levine, V., Saleem, R., Spitznagel, E., Joist, J.H. Lancet (1999) [Pubmed]
  22. Sickle erythrocyte-endothelial interactions in microcirculation: the role of von Willebrand factor and implications for vasoocclusion. Kaul, D.K., Nagel, R.L., Chen, D., Tsai, H.M. Blood (1993) [Pubmed]
  23. Biologic response to desmopressin in patients with severe type 1 and type 2 von Willebrand disease: results of a multicenter European study. Federici, A.B., Mazurier, C., Berntorp, E., Lee, C.A., Scharrer, I., Goudemand, J., Lethagen, S., Nitu, I., Ludwig, G., Hilbert, L., Mannucci, P.M. Blood (2004) [Pubmed]
  24. Effects of alpha-thalassemia and sickle polymerization tendency on the urine-concentrating defect of individuals with sickle cell trait. Gupta, A.K., Kirchner, K.A., Nicholson, R., Adams, J.G., Schechter, A.N., Noguchi, C.T., Steinberg, M.H. J. Clin. Invest. (1991) [Pubmed]
  25. Hemostatic effects of tranexamic acid and desmopressin during cardiac surgery. Horrow, J.C., Van Riper, D.F., Strong, M.D., Brodsky, I., Parmet, J.L. Circulation (1991) [Pubmed]
  26. Absence of a desmopressin response after therapeutic expression of factor VIII in hemophilia A dogs with liver-directed neonatal gene therapy. Xu, L., Nichols, T.C., Sarkar, R., McCorquodale, S., Bellinger, D.A., Ponder, K.P. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  27. In vitro desensitization of isolated nephron segments to vasopressin. Dublineau, I., Pradelles, P., de Rouffignac, C., Elalouf, J.M. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  28. von Willebrand factor interaction with the glycoprotein IIb/IIa complex. Its role in platelet function as demonstrated in patients with congenital afibrinogenemia. De Marco, L., Girolami, A., Zimmerman, T.S., Ruggeri, Z.M. J. Clin. Invest. (1986) [Pubmed]
  29. Effects of antidiuretic hormone on urinary acidification and on tubular handling of bicarbonate in the rat. Bichara, M., Mercier, O., Houillier, P., Paillard, M., Leviel, F. J. Clin. Invest. (1987) [Pubmed]
  30. L-histidine augments the response to 1-deamino-8-D-arginine vasopressin in Brattleboro homozygous (di/di) rats. Charnogursky, G., Moses, A.M., Coulson, R., Bernstein, M., Carvounis, C.P. J. Clin. Invest. (1990) [Pubmed]
  31. Evidence of a local mechanism for desmopressin-induced tissue-type plasminogen activator release in human forearm. Wall, U., Jern, S., Tengborn, L., Jern, C. Blood (1998) [Pubmed]
  32. The application of the combined corticotropin-releasing hormone plus desmopressin stimulation during petrosal sinus sampling is both sensitive and specific in differentiating patients with Cushing's disease from patients with the occult ectopic adrenocorticotropin syndrome. Tsagarakis, S., Vassiliadi, D., Kaskarelis, I.S., Komninos, J., Souvatzoglou, E., Thalassinos, N. J. Clin. Endocrinol. Metab. (2007) [Pubmed]
  33. Relief of nocturnal enuresis by desmopressin is kidney and vasopressin type 2 receptor independent. Robben, J.H., Sze, M., Knoers, N.V., Eggert, P., Deen, P., Müller, D. J. Am. Soc. Nephrol. (2007) [Pubmed]
  34. Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP. Kaufmann, J.E., Oksche, A., Wollheim, C.B., Günther, G., Rosenthal, W., Vischer, U.M. J. Clin. Invest. (2000) [Pubmed]
  35. Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. Ma, T., Song, Y., Yang, B., Gillespie, A., Carlson, E.J., Epstein, C.J., Verkman, A.S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  36. Changes in von Willebrand factor-cleaving protease (ADAMTS13) activity after infusion of desmopressin. Reiter, R.A., Knöbl, P., Varadi, K., Turecek, P.L. Blood (2003) [Pubmed]
  37. Mutations in the vasopressin V2 receptor and aquaporin-2 genes in 12 families with congenital nephrogenic diabetes insipidus. Vargas-Poussou, R., Forestier, L., Dautzenberg, M.D., Niaudet, P., Déchaux, M., Antignac, C. J. Am. Soc. Nephrol. (1997) [Pubmed]
  38. Treatment with desmopressin acetate to reduce blood loss after cardiac surgery. A double-blind randomized trial. Salzman, E.W., Weinstein, M.J., Weintraub, R.M., Ware, J.A., Thurer, R.L., Robertson, L., Donovan, A., Gaffney, T., Bertele, V., Troll, J. N. Engl. J. Med. (1986) [Pubmed]
  39. 1-Desamino-8-D-arginine vasopressin (desmopressin) decreases operative blood loss in patients having Harrington rod spinal fusion surgery. A randomized, double-blinded, controlled trial. Kobrinsky, N.L., Letts, R.M., Patel, L.R., Israels, E.D., Monson, R.C., Schwetz, N., Cheang, M.S. Ann. Intern. Med. (1987) [Pubmed]
  40. Nasal spray desmopressin (DDAVP) for mild hemophilia A and von Willebrand disease. Rose, E.H., Aledort, L.M. Ann. Intern. Med. (1991) [Pubmed]
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