- The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse. Badour, K., Zhang, J., Shi, F., McGavin, M.K., Rampersad, V., Hardy, L.A., Field, D., Siminovitch, K.A. Immunity (2003)