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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival.

Recent studies have demonstrated cyclooxygenase 2 ( COX-2) overexpression in various human malignancies, especially in breast cancer, where COX-2 turned out to be a predictor of poor survival. To evaluate the relation of COX-2 and Ep-CAM overexpression and its prognostic significance, we performed a retrospective study on 212 breast cancer patients with a median follow-up time of 10.5 years. Overexpression of COX-2 in tumour tissue samples was assessed by immunohistochemistry. COX-2 overexpression was found in 48.6% of the tumour samples and was predictive for poor disease-free and overall survival. Univariate analysis revealed a strong correlation between COX-2 and Ep-CAM overexpression (P=0.009). Concurrent COX-2 and Ep-CAM overexpression was present in 21.7% of tumour specimens and had an additive negative impact on disease-free and overall survival. Determination of both tumour markers should help in guiding new therapeutic strategies in patients with invasive breast cancer.[1]


  1. Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival. Spizzo, G., Gastl, G., Wolf, D., Gunsilius, E., Steurer, M., Fong, D., Amberger, A., Margreiter, R., Obrist, P. Br. J. Cancer (2003) [Pubmed]
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