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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities.

Twenty-one pyridine-2-carboxylate derivatives were prepared by the coupling of 6-formyl-2-carboxylic acid with the corresponding phenol, thiophenol, and aniline, substituted with various functional groups. Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity.[1]

References

  1. Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities. Jew, S.S., Park, B.S., Lim, D.Y., Kim, M.G., Chung, I.K., Kim, J.H., Hong, C.I., Kim, J.K., Park, H.J., Lee, J.H., Park, H.G. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
 
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