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Gene Review

TEP1  -  telomerase-associated protein 1

Homo sapiens

Synonyms: TLP1, TP1, TROVE1, Telomerase protein 1, Telomerase protein component 1, ...
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Disease relevance of TEP1


Psychiatry related information on TEP1


High impact information on TEP1


Chemical compound and disease context of TEP1


Biological context of TEP1


Anatomical context of TEP1


Associations of TEP1 with chemical compounds


Physical interactions of TEP1


Enzymatic interactions of TEP1


Regulatory relationships of TEP1


Other interactions of TEP1


Analytical, diagnostic and therapeutic context of TEP1


  1. PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells. Li, D.M., Sun, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells. Furnari, F.B., Huang, H.J., Cavenee, W.K. Cancer Res. (1998) [Pubmed]
  3. PTEN induces chemosensitivity in PTEN-mutated prostate cancer cells by suppression of Bcl-2 expression. Huang, H., Cheville, J.C., Pan, Y., Roche, P.C., Schmidt, L.J., Tindall, D.J. J. Biol. Chem. (2001) [Pubmed]
  4. Silencing of the PTEN tumor-suppressor gene in anaplastic thyroid cancer. Frisk, T., Foukakis, T., Dwight, T., Lundberg, J., Höög, A., Wallin, G., Eng, C., Zedenius, J., Larsson, C. Genes Chromosomes Cancer (2002) [Pubmed]
  5. Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers. Kohno, T., Takahashi, M., Manda, R., Yokota, J. Genes Chromosomes Cancer (1998) [Pubmed]
  6. Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Ulaner, G.A., Hu, J.F., Vu, T.H., Giudice, L.C., Hoffman, A.R. Cancer Res. (1998) [Pubmed]
  7. Emerging neuroprotective strategies for Alzheimer's disease: dietary restriction, telomerase activation, and stem cell therapy. Mattson, M.P. Exp. Gerontol. (2000) [Pubmed]
  8. Role of Ets/Id proteins for telomerase regulation in human cancer cells. Xiao, X., Athanasiou, M., Sidorov, I.A., Horikawa, I., Cremona, G., Blair, D., Barret, J.C., Dimitrov, D.S. Exp. Mol. Pathol. (2003) [Pubmed]
  9. SV40 large T-antigen and human pleural mesothelioma. Screening by polymerase chain reaction and tyramine-amplified immunohistochemistry. Dhaene, K., Verhulst, A., Van Marck, E. Virchows Arch. (1999) [Pubmed]
  10. Venture science: climbing the ladder to telomerase, cognitive therapy and in situ hybridization. Goldstein, J.L. Nat. Med. (2006) [Pubmed]
  11. The structure and function of telomerase reverse transcriptase. Autexier, C., Lue, N.F. Annu. Rev. Biochem. (2006) [Pubmed]
  12. Eukaryotic DNA polymerases. Hubscher, U., Maga, G., Spadari, S. Annu. Rev. Biochem. (2002) [Pubmed]
  13. Ciliate telomerase biochemistry. Collins, K. Annu. Rev. Biochem. (1999) [Pubmed]
  14. Telomere length regulation. Greider, C.W. Annu. Rev. Biochem. (1996) [Pubmed]
  15. Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells. Zhang, R.G., Zhang, R.P., Wang, X.W., Xie, H. Cell Res. (2002) [Pubmed]
  16. Expression of telomerase genes in thyroid carcinoma. Hoang-Vu, C., Boltze, C., Gimm, O., Poremba, C., Dockhorn-Dworniczak, B., Köhrle, J., Rath, F.W., Dralle, H. Int. J. Oncol. (2002) [Pubmed]
  17. Telomerase inhibition and telomere loss in BEL-7404 human hepatoma cells treated with doxorubicin. Zhang, R.G., Guo, L.X., Wang, X.W., Xie, H. World J. Gastroenterol. (2002) [Pubmed]
  18. The expression of telomeric proteins and their probable regulation of telomerase during the differentiation of all-trans-retinoic acid-responsive and -resistant acute promyelocytic leukemia cells. Sun, J., Huang, H., Zhu, Y., Lan, J., Li, J., Lai, X., Yu, J. Int. J. Hematol. (2005) [Pubmed]
  19. Telomerase activity, estrogen receptors (alpha, beta), Bcl-2 expression in human breast cancer and treatment response. Murillo-Ortiz, B., Astudillo-De la Vega, H., Castillo-Medina, S., Malacara, J.M., Benitez-Bribiesca, L. BMC Cancer (2006) [Pubmed]
  20. PTEN gene alterations in lymphoid neoplasms. Sakai, A., Thieblemont, C., Wellmann, A., Jaffe, E.S., Raffeld, M. Blood (1998) [Pubmed]
  21. PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Huang, H., Potter, C.J., Tao, W., Li, D.M., Brogiolo, W., Hafen, E., Sun, H., Xu, T. Development (1999) [Pubmed]
  22. Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. Gimm, O., Perren, A., Weng, L.P., Marsh, D.J., Yeh, J.J., Ziebold, U., Gil, E., Hinze, R., Delbridge, L., Lees, J.A., Mutter, G.L., Robinson, B.G., Komminoth, P., Dralle, H., Eng, C. Am. J. Pathol. (2000) [Pubmed]
  23. Somatic mutations of the PTEN tumor suppressor gene in sporadic follicular thyroid tumors. Halachmi, N., Halachmi, S., Evron, E., Cairns, P., Okami, K., Saji, M., Westra, W.H., Zeiger, M.A., Jen, J., Sidransky, D. Genes Chromosomes Cancer (1998) [Pubmed]
  24. Alternative splicing of the human PTEN/MMAC1/TEP1 gene. Sharrard, R.M., Maitland, N.J. Biochim. Biophys. Acta (2000) [Pubmed]
  25. PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines. Kondo, K., Yao, M., Kobayashi, K., Ota, S., Yoshida, M., Kaneko, S., Baba, M., Sakai, N., Kishida, T., Kawakami, S., Uemura, H., Nagashima, Y., Nakatani, Y., Hosaka, M. Int. J. Cancer (2001) [Pubmed]
  26. Role of human telomerase reverse transcriptase and telomeric-repeat binding factor proteins 1 and 2 in human hematopoietic cells. Yamada, K., Yajima, T., Yagihashi, A., Kobayashi, D., Koyanagi, Y., Asanuma, K., Yamada, M., Moriai, R., Kameshima, H., Watanabe, N. Jpn. J. Cancer Res. (2000) [Pubmed]
  27. Differential gene expression of human telomerase-associated protein hTERT and TEP1 in human hematopoietic cells. Uchida, N., Otsuka, T., Shigematsu, H., Maeda, M., Sugio, Y., Itoh, Y., Niho, Y. Leuk. Res. (1999) [Pubmed]
  28. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nakayama, J., Tahara, H., Tahara, E., Saito, M., Ito, K., Nakamura, H., Nakanishi, T., Tahara, E., Ide, T., Ishikawa, F. Nat. Genet. (1998) [Pubmed]
  29. Severe growth defect in mouse cells lacking the telomerase RNA component. Niida, H., Matsumoto, T., Satoh, H., Shiwa, M., Tokutake, Y., Furuichi, Y., Shinkai, Y. Nat. Genet. (1998) [Pubmed]
  30. Raloxifene increases proliferation and up-regulates telomerase activity in human umbilical vein endothelial cells. Doshida, M., Ohmichi, M., Tsutsumi, S., Kawagoe, J., Takahashi, T., Du, B., Mori-Abe, A., Ohta, T., Saitoh-Sekiguchi, M., Takahashi, K., Kurachi, H. J. Biol. Chem. (2006) [Pubmed]
  31. Telomerase activity reconstituted in vitro with purified human telomerase reverse transcriptase and human telomerase RNA component. Masutomi, K., Kaneko, S., Hayashi, N., Yamashita, T., Shirota, Y., Kobayashi, K., Murakami, S. J. Biol. Chem. (2000) [Pubmed]
  32. Retinoic acid inhibits telomerase activity and downregulates expression but does not affect splicing of hTERT: correlation with cell growth rate inhibition in an in vitro cervical carcinogenesis/multidrug-resistance model. Ding, Z., Green, A.G., Yang, X., Chernenko, G., Tang, S.C., Pater, A. Exp. Cell Res. (2002) [Pubmed]
  33. Functional conservation of the telomerase protein Est1p in humans. Snow, B.E., Erdmann, N., Cruickshank, J., Goldman, H., Gill, R.M., Robinson, M.O., Harrington, L. Curr. Biol. (2003) [Pubmed]
  34. Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit. Moriarty, T.J., Huard, S., Dupuis, S., Autexier, C. Mol. Cell. Biol. (2002) [Pubmed]
  35. Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Lin, J., Blackburn, E.H. Genes Dev. (2004) [Pubmed]
  36. Nucleolin interacts with telomerase. Khurts, S., Masutomi, K., Delgermaa, L., Arai, K., Oishi, N., Mizuno, H., Hayashi, N., Hahn, W.C., Murakami, S. J. Biol. Chem. (2004) [Pubmed]
  37. Small-molecule-based identification of dynamic assembly of E2F-pocket protein-histone deacetylase complex for telomerase regulation in human cells. Won, J., Chang, S., Oh, S., Kim, T.K. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  38. The unmasking of telomerase. Legassie, J.D., Jarstfer, M.B. Structure (2006) [Pubmed]
  39. hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells. Chang, J.T., Lu, Y.C., Chen, Y.J., Tseng, C.P., Chen, Y.L., Fang, C.W., Cheng, A.J. Br. J. Cancer (2006) [Pubmed]
  40. Characterization of telomere-binding activity of replication factor C large subunit p140. Uchiumi, F., Watanabe, M., Tanuma, S. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  41. Regulative function of extracellular regulated protein kinases and telomerase in apoptosis of hepatocarcinomatous and leukemic cell lines. Li, D.J., Zhang, Y.Z., Meng, F.K., Zhang, D.H., Liu, W.L. Zhongguo Shi Yan Xue Ye Xue Za Zhi (2002) [Pubmed]
  42. Telomere length homeostasis requires that telomerase levels are limiting. Cristofari, G., Lingner, J. EMBO J. (2006) [Pubmed]
  43. Characterization of physical and functional anchor site interactions in human telomerase. Wyatt, H.D., Lobb, D.A., Beattie, T.L. Mol. Cell. Biol. (2007) [Pubmed]
  44. Basic FGF-induced activation of telomerase in rheumatoid synoviocytes. Tsumuki, H., Hasunuma, T., Kobata, T., Kato, T., Uchida, A., Nishioka, K. Rheumatol. Int. (2000) [Pubmed]
  45. Function of HSP90 and p23 in the telomerase complex of thyroid tumors. Boltze, C., Schneider-Stock, R., Roessner, A., Quednow, C., Hoang-Vu, C. Pathol. Res. Pract. (2003) [Pubmed]
  46. Variant forms of upstream stimulatory factors (USFs) control the promoter activity of hTERT, the human gene encoding the catalytic subunit of telomerase. Yago, M., Ohki, R., Hatakeyama, S., Fujita, T., Ishikawa, F. FEBS Lett. (2002) [Pubmed]
  47. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Zhou, X.Z., Lu, K.P. Cell (2001) [Pubmed]
  48. Structure of the human telomerase RNA pseudoknot reveals conserved tertiary interactions essential for function. Theimer, C.A., Blois, C.A., Feigon, J. Mol. Cell (2005) [Pubmed]
  49. Transforming growth factor beta suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene. Li, H., Xu, D., Li, J., Berndt, M.C., Liu, J.P. J. Biol. Chem. (2006) [Pubmed]
  50. Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating RB/E2F pathway. Xiang, H., Wang, J., Mao, Y., Liu, M., Reddy, V.N., Li, D.W. Oncogene (2002) [Pubmed]
  51. Cryoelectron microscopy imaging of recombinant and tissue derived vaults: localization of the MVP N termini and VPARP. Mikyas, Y., Makabi, M., Raval-Fernandes, S., Harrington, L., Kickhoefer, V.A., Rome, L.H., Stewart, P.L. J. Mol. Biol. (2004) [Pubmed]
  52. Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases. Saito, T., Matsuda, Y., Suzuki, T., Hayashi, A., Yuan, X., Saito, M., Nakayama, J., Hori, T., Ishikawa, F. Genomics (1997) [Pubmed]
  53. The genetic basis of Cowden's syndrome: three novel mutations in PTEN/MMAC1/TEP1. Tsou, H.C., Ping, X.L., Xie, X.X., Gruener, A.C., Zhang, H., Nini, R., Swisshelm, K., Sybert, V., Diamond, T.M., Sutphen, R., Peacocke, M. Hum. Genet. (1998) [Pubmed]
  54. Establishment of quantitative reverse transcription--polymerase chain reaction assays for human telomerase-associated genes. Yajima, T., Yagihashi, A., Kameshima, H., Furuya, D., Kobayashi, D., Hirata, K., Watanabe, N. Clin. Chim. Acta (2000) [Pubmed]
  55. Telomerase- and alternative telomere lengthening-independent telomere stabilization in a metastasis-derived human non-small cell lung cancer cell line: effect of ectopic hTERT. Brachner, A., Sasgary, S., Pirker, C., Rodgarkia, C., Mikula, M., Mikulits, W., Bergmeister, H., Setinek, U., Wieser, M., Chin, S.F., Caldas, C., Micksche, M., Cerni, C., Berger, W. Cancer Res. (2006) [Pubmed]
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