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Chemical Compound Review:

PubChem6803 3,4-dichlorobenzenethiol

Synonyms: SureCN364114, ACMC-1ASET, AG-E-21598, ANW-32987, KB-28208, ...

Jew, S.S. et al., Preussmann, R. et al., Kroeger-Koepke, M.B. et al., Ohashi, Y. et al.

Jew, Park, Lim, Kim, Chung, Kim, Hong, Kim, Park, Lee, Park,

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High impact information on EINECS 227-485-3

We conclude that 3,4-dichlorobenzenethiol should be used with caution in studies of alkylation during the in vitro metabolism of carcinogenic nitrosamines [1].
Letter: In vitro detection of nitrosamines and other indirect alkylating agents by reaction with 3,4-dichlorothiophenol in the presence of rat liver microsomes [2].
Among them, the 3,4-dichlorothiophenol ester (9p) showed the highest in vitro telomerase inhibitory activity and quite significant in vivo tumor suppression activity [3].
3,4-Dichlorothiophenol and 3,5-dichlorothiophenol showed very potent inhibition and their IC50 values were 5.3 and 5.2 microM, respectively [4].

References

Use of 3,4-dichlorobenzenethiol as a trapping agent for alkylating intermediates during in vitro metabolism of nitrosamines. Kroeger-Koepke, M.B., Michejda, C.J., Roller, P.P., Keefer, L.K. Cancer Res. (1985) [Pubmed]
Letter: In vitro detection of nitrosamines and other indirect alkylating agents by reaction with 3,4-dichlorothiophenol in the presence of rat liver microsomes. Preussmann, R., Arjungi, K.N., Ebers, G. Cancer Res. (1976) [Pubmed]
Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities. Jew, S.S., Park, B.S., Lim, D.Y., Kim, M.G., Chung, I.K., Kim, J.H., Hong, C.I., Kim, J.K., Park, H.J., Lee, J.H., Park, H.G. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
Inhibition of human cytochrome P450 2E1 by halogenated anilines, phenols, and thiophenols. Ohashi, Y., Yamada, K., Takemoto, I., Mizutani, T., Saeki, K. Biol. Pharm. Bull. (2005) [Pubmed]

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