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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Enterobactin: an archetype for microbial iron transport.

Bacteria have aggressive acquisition processes for iron, an essential nutrient. Siderophores are small iron chelators that facilitate cellular iron transport. The siderophore enterobactin is a triscatechol derivative of a cyclic triserine lactone. Studies of the chemistry, regulation, synthesis, recognition, and transport of enterobactin make it perhaps the best understood of the siderophore-mediated iron uptake systems, displaying a lot of function packed into this small molecule. However, recent surprises include the isolation of corynebactin, a closely related trithreonine triscatechol derivative lactone first found in Gram-positive bacteria, and the crystal structure of a ferric enterobactin complex of a protein identified as an antibacterial component of the human innate immune system.[1]


  1. Enterobactin: an archetype for microbial iron transport. Raymond, K.N., Dertz, E.A., Kim, S.S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
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