Another tie that binds the MTA family to breast cancer.
In this issue of Cell, demonstrate that MTA3 is an estrogen-dependent component of the NuRD complex and identify the Snail gene as its direct target. ER signaling upregulates MTA3 levels to negatively modulate Snail- mediated repression of E-cadherin. These findings may explain how ER status controls epithelial-to-mesenchymal transition in human breast tumors.[1]References
- Another tie that binds the MTA family to breast cancer. Kumar, R. Cell (2003) [Pubmed]
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