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Gene Review

MTA3  -  metastasis associated 1 family, member 3

Homo sapiens

Synonyms: KIAA1266, Metastasis-associated protein MTA3
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Disease relevance of MTA3

  • Furthermore, the status of the ER pathway modulates the expression of MTA3 as well as epithelial-to-mesenchymal transition in human breast tumors [1].
  • MTA3 was exclusively expressed in a subset of cells of ER-positive premalignant lesions but not in carcinomas [2].

High impact information on MTA3


Chemical compound and disease context of MTA3


Biological context of MTA3

  • MTA1, MTA2, and MTA3 are components of the nucleosome remodeling and deacetylation complex, which is associated with adenosine triphosphate-dependent chromatin remodeling and transcriptional regulation [1].
  • Molecular dissection of the MTA3 promoter using transient transfection assays identified a composite element required for high-level transcription consisting of an SP1 site in close proximity to a consensus estrogen response element half-site [6].
  • Oestrogen receptor alpha represses gene expression by transrepressing the activity of the transcription factors such as nuclear factor-kappaB or by inducing the expression of transcriptional suppressors such as MTA3 [7].
  • A recent paper in Cell (Fujita et al., 2003) demonstrates that MTA3, a novel component of the Mi-2/NuRD transcriptional repression complex, is an estrogen receptor-regulated inhibitor of the Snail zinc finger transcription factor in breast cancer [8].

Anatomical context of MTA3


Regulatory relationships of MTA3

  • The MTA3 gene thus joins a growing list of loci regulated by both SP1 and ER [6].

Other interactions of MTA3

  • We also report the finding of human MTA3, which is highly homologous to both MTA1 and MTA2 [9].
  • Depletion of MTA3 by RNAi impairs BCL-6-dependent repression and alters the cell-specific transcriptional pattern characteristic of the B lymphocyte [3].


  1. Emerging roles of MTA family members in human cancers. Kumar, R., Wang, R.A., Bagheri-Yarmand, R. Semin. Oncol. (2003) [Pubmed]
  2. Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer. Zhang, H., Stephens, L.C., Kumar, R. Clin. Cancer Res. (2006) [Pubmed]
  3. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Fujita, N., Jaye, D.L., Geigerman, C., Akyildiz, A., Mooney, M.R., Boss, J.M., Wade, P.A. Cell (2004) [Pubmed]
  4. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Fujita, N., Jaye, D.L., Kajita, M., Geigerman, C., Moreno, C.S., Wade, P.A. Cell (2003) [Pubmed]
  5. Another tie that binds the MTA family to breast cancer. Kumar, R. Cell (2003) [Pubmed]
  6. Hormonal regulation of metastasis-associated protein 3 transcription in breast cancer cells. Fujita, N., Kajita, M., Taysavang, P., Wade, P.A. Mol. Endocrinol. (2004) [Pubmed]
  7. Tumour necrosis factor and PI3-kinase control oestrogen receptor alpha protein level and its transrepression function. Bhat-Nakshatri, P., Campbell, R.A., Patel, N.M., Newton, T.R., King, A.J., Marshall, M.S., Ali, S., Nakshatri, H. Br. J. Cancer (2004) [Pubmed]
  8. Connecting estrogen receptor function, transcriptional repression, and E-cadherin expression in breast cancer. Fearon, E.R. Cancer Cell (2003) [Pubmed]
  9. The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. Yao, Y.L., Yang, W.M. J. Biol. Chem. (2003) [Pubmed]
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